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Biology, Volume 14, Issue 8

2025 August - 201 articles

RESEARCH CHALLENGES IN STAGE III AND IV RAS-ASSOCIATED CANCERS
Cover Story: Mutations in KRAS, HRAS, and NRAS transform essential regulators of cell growth into potent cancer drivers, especially in advanced disease. These altered Ras proteins rewire pathways like MAPK and PI3K, fueling tumor growth, adaptability, and drug resistance. Drawing from human, mouse, and Drosophila models, our review maps where normal Ras biology diverges into tumorigenic complexity. We examine why decades of targeted strategies have fallen short and highlight the need for physiologically relevant models that can keep pace with tumor evolution, paving the way for more effective therapies against RAS-driven cancers. View this paper
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Articles (201)

  • Article
  • Open Access
859 Views
21 Pages

Transcriptome Screening and Identification of Chemosensory Genes in the Goji Berry Psyllid, Bactericera gobica (Hemiptera: Psyllidae)

  • Zhanghui Liu,
  • Yang Ge,
  • Zekun Zhang,
  • Jiayi Liang,
  • Chuanzhi Kang,
  • Chengcai Zhang,
  • Kang Chen,
  • Xiufu Wan,
  • Liu Zhang and
  • Honghao Chen
  • + 1 author

21 August 2025

Goji berry is widely consumed worldwide and holds substantial market value, yet its cultivation faces significant threats from the goji berry psyllid (Bactericera gobica). Chemosensory-related genes play critical roles in regulating insect behaviors,...

  • Article
  • Open Access
1 Citations
994 Views
16 Pages

21 August 2025

Liriope muscari is a medicinal and ornamental herbaceous plant with significant economic value, as its tuberous roots are used for medicinal purposes. However, the current production of medicinal plants is characterized by wasteful use of resources a...

  • Article
  • Open Access
644 Views
13 Pages

21 August 2025

Argopecten irradians concentricus has become one of the pillar industries in the aquaculture of the Beibu Gulf since it was introduced into China in 1991. This study examined how stocking density and culture site affects growth in breeding population...

  • Article
  • Open Access
1,375 Views
18 Pages

Starvation Influences the Microbiota in the Stomach of the Corallivorous Crown-of-Thorns Starfish

  • Ying Zhang,
  • Fuxiang Lai,
  • Litong Yang,
  • Liling Dai,
  • Nan Su,
  • Jianxing Hu,
  • Huizhen Chen,
  • Qian Gao,
  • Fanyu Zheng and
  • Chang Chen

21 August 2025

The crown-of-thorns starfish (CoTS, Acanthaster spp.), is responsible for a considerable amount of coral loss in the tropical Indo-Pacific region. After decimating coral populations through predation, it is expected that CoTS will face food scarcity...

  • Article
  • Open Access
2 Citations
1,259 Views
20 Pages

21 August 2025

Echinostomatidae is a taxonomically complex group with substantial species diversity and richness. The vast majority of species in this family parasitize birds and mammals, including humans, causing significant economic losses and medical costs. In t...

  • Article
  • Open Access
1,035 Views
27 Pages

21 August 2025

Biodiversity in arid river basins is highly climate-sensitive, yet the multi-pathway relations among the environment, landscape structure, connectivity, and plant diversity remain unclear. Framed by a scale–place–space sustainability pers...

  • Review
  • Open Access
3 Citations
1,895 Views
18 Pages

21 August 2025

N, as plants’ most essential nutrient, profoundly shapes root system architecture (RSA), with LRs being preferentially regulated. This review synthesizes the intricate molecular mechanisms underpinning N sensing, signaling, and its integration...

  • Article
  • Open Access
1,546 Views
23 Pages

Galangin and 1′-Acetoxychavicol Acetate from Galangal (Alpinia galanga) Suppress Lymphoma Growth via c-Myc Downregulation and Apoptosis Induction

  • Sirinya Moakmamern,
  • Lapamas Rueankham,
  • Natsima Viriyaadhammaa,
  • Kittikawin Panyakham,
  • Natnicha Khakhai,
  • Pinyaphat Khamphikham,
  • Suwit Duangmano,
  • Siriporn Okonogi,
  • Sawitree Chiampanichayakul and
  • Songyot Anuchapreeda

21 August 2025

The c-Myc protein, a key regulator of cell proliferation, growth, and apoptosis in B-cell lymphocytes, is frequently dysregulated in Burkitt’s lymphoma. Zingiberaceae plants—galangal (Alpinia galanga), black turmeric (Curcuma aeroginosa),...

  • Article
  • Open Access
1,098 Views
24 Pages

Genome-Wide Identification, Characterization, and Expression Analysis of NRT Gene Family in Suaeda glauca

  • Zitong Ou,
  • Jin Sun,
  • Xueli Li,
  • Haoran Feng,
  • Xingguang Chen,
  • Sisi Liang,
  • Zhonghua Guo,
  • Lulu Wang,
  • Xiaoping Niu and
  • Yan Cheng
  • + 3 authors

21 August 2025

Nitrogen (N) is crucial for plant growth and stress resistance and is primarily absorbed and transported by nitrate transporters (NRT). Suaeda glauca, known for its strong salt-alkali stress resistance, and SgNRT genes have rarely been reported. This...

  • Article
  • Open Access
1 Citations
1,291 Views
28 Pages

21 August 2025

Overuse of chemical fertilizers can threaten the agro-ecological balance, including an excessive accumulation of certain elements, such as nitrogen and phosphorus. On the other hand, organic fertilizers and biofertilizers, which are eco-friendly and...

  • Article
  • Open Access
854 Views
14 Pages

21 August 2025

Palaemon gravieri is an ecologically important shrimp species that plays a vital role in depressing jellyfish blooms in the southern Yellow and East China Seas of China. However, information on its distribution pattern and migration route related to...

  • Article
  • Open Access
821 Views
17 Pages

The Role of MHC-II Diversity over Enclosure Design in Gut Microbiota Structuring of Captive Bengal Slow Lorises

  • Rong Jiang,
  • Xiaojia Zhang,
  • Lei Xie,
  • Yan Zhang,
  • Changjun Zeng,
  • Yongfang Yao,
  • Huailiang Xu,
  • Caoyang Yang,
  • Xiao Wang and
  • Chuanren Li
  • + 2 authors

21 August 2025

The endangered Bengal slow loris (Nycticebus bengalensis) relies heavily on captive/rescue populations for conservation. This study investigated the critical link between Major Histocompatibility Complex (MHC) class II DRB1 exon 2 (DRB1e2) genetic va...

  • Article
  • Open Access
1,211 Views
15 Pages

Identification and Evaluation of Thermotolerance in Broccoli Seedlings Based on a Multi-Trait Phenotyping System

  • Xuaner Li,
  • Yongyu Zhao,
  • Tiemin Xu,
  • Xigang Feng,
  • Fengqing Han,
  • Dongna Wen,
  • Yumei Liu,
  • Wenzheng Gao,
  • Zhiwei Zhao and
  • Zhansheng Li

21 August 2025

To establish a systematic approach for evaluating heat tolerance at the seedling stage in broccoli, we investigated 14 representative cultivars cultivated in China. Physiological indicators such as electrical conductivity, malondialdehyde, proline, a...

  • Article
  • Open Access
2 Citations
1,525 Views
26 Pages

Microbiome Diversity and Dynamics in Lotus–Fish Co-Culture Versus Intensive Pond Systems: Implications for Sustainable Aquaculture

  • Qianqian Zeng,
  • Ziyi Wang,
  • Zhongyuan Shen,
  • Wuhui Li,
  • Kaikun Luo,
  • Qinbo Qin,
  • Shengnan Li and
  • Qianhong Gu

20 August 2025

The lotus–fish co-culture (LFC) system leverages plant–fish symbiosis to optimize aqua-culture environments, enhancing both economic and ecological yields. However, the eco-logical mechanisms of microbial communities in LFC systems remain...

  • Article
  • Open Access
1,468 Views
18 Pages

One Shock, Not One Cure: Electroporation Reveals Disease-Specific Constraints in Hepatocyte Gene Editing Therapy

  • Callie Clark,
  • Menam Pokhrel,
  • Benjamin Arthur,
  • Pramita Suresh,
  • Ilayda Ates,
  • Justin Gibson,
  • Abishek Dhungana,
  • Ryan Mehlem,
  • Andrew Boysia and
  • Renee N. Cottle
  • + 7 authors

20 August 2025

We previously demonstrated lipid nanoparticle-mediated CRISPR-Cas9 gene editing to disrupt the gene encoding cytochrome P450 oxidoreductase (Cypor), combined with transient administration of acetaminophen (APAP), to repopulate the liver with healthy...

  • Review
  • Open Access
3 Citations
3,068 Views
23 Pages

20 August 2025

The human sphenoid bone (SB), centrally located at the cranial base, is structurally and developmentally complex. It arises from multiple cartilaginous precursors and undergoes both endochondral and intramembranous ossification, forming essential ele...

  • Article
  • Open Access
2 Citations
1,209 Views
23 Pages

20 August 2025

This study investigated the effects of dietary supplementation with varying levels (CK: 0.0 g/kg; RL: 0.1 g/kg; RM: 1.0 g/kg; RH: 10.0 g/kg) of Rhodotorula mucilaginosa on muscle composition, serum biochemical indicators, antioxidant capacity, lipid...

  • Review
  • Open Access
1 Citations
4,441 Views
19 Pages

20 August 2025

This review explores the therapeutic potential of Allium cepa (onion) and Allium sativum (garlic), focusing specifically on their antidiabetic, cardioprotective, and antibacterial effects. These widely used medicinal plants are rich in bioactive comp...

  • Article
  • Open Access
1 Citations
1,080 Views
20 Pages

Linarin and Hyperoside Inhibit lptD/msbA to Disrupt Membranes of Multidrug-Resistant Acinetobacter baumannii

  • Yuqi Yang,
  • Xue Li,
  • Yunshi Chen,
  • Yan Zhang,
  • Lailai Li,
  • Yihui Chai,
  • Xiang Pu and
  • Xin Liu

20 August 2025

Against the backdrop of rising multidrug-resistant Acinetobacter baumannii (MDR AB) threats, this study explores the in vitro antibacterial activity and mechanism of Senecio scandens (a Miao ethnic medicinal herb) crude extract. Using 10 clinical MDR...

  • Review
  • Open Access
2 Citations
2,264 Views
30 Pages

Exploring the Molluscan Microbiome: Diversity, Function, and Ecological Implications

  • Tsireledzo Goodwill Makwarela,
  • Nimmi Seoraj-Pillai and
  • Tshifhiwa Constance Nangammbi

20 August 2025

Mollusks are among the most ecologically and economically significant invertebrates; yet, their associated microbiomes remain understudied relative to those of other metazoans. This scoping review synthesizes the current literature on the diversity,...

  • Retraction
  • Open Access
590 Views
1 Page

20 August 2025

The Biology Editorial Office retracts the paper entitled “Cross-Generational Impact of Epigenetic Male Influence on Physical Activity in Rat” [...]

  • Article
  • Open Access
1 Citations
1,274 Views
17 Pages

Enhancing Pollinator Support: Plant–Pollinator Dynamics Between Salvia yangii and Anthidium Bees in Anthropogenic Landscapes

  • Daniela Lupi,
  • Claudia Giuliani,
  • Gelsomina Fico,
  • Serena Malabusini,
  • Carla Sorvillo and
  • Manuela Giovanetti

19 August 2025

Anthropogenic environments are increasingly recognised for their potential to support pollinator diversity, especially through the strategic selection of ornamental plant species. This study investigated the ecological role of Salvia yangii (formerly...

  • Article
  • Open Access
1 Citations
1,792 Views
19 Pages

Taurine Supplementation Enhances the Resistance of Litopenaeus vannamei Postlarvae to Low-Salinity Stress

  • Huaichi Wang,
  • Xinyue Du,
  • Jiahong Zou,
  • Mengya Wang,
  • Yan Lei,
  • Bin Zhang,
  • Yongzhen Zhao,
  • Linyuan Jiang,
  • Xiaohan Chen and
  • Qingchao Wang

19 August 2025

In aquaculture, Pacific white shrimp (Litopenaeus vannamei) growth in low-salinity waters is limited by osmoregulatory stress; therefore, improving resistance to low-salinity stress via nutritional modulation is key. In the present study, shrimp post...

  • Article
  • Open Access
1,431 Views
18 Pages

Parasitic Fauna of Lepus europaeus and Lepus timidus in Kazakhstan: Parasitological Profile and Molecular Identification

  • Vladimir Kiyan,
  • Ainura Smagulova,
  • Nurassyl Manapov,
  • Karina Jazina,
  • Rabiga Uakhit,
  • Aitbay Bulashev,
  • Lyudmila Lider and
  • Sergey Leontyev

19 August 2025

Hares (Lepus europaeus and Lepus timidus) play important ecological and economic roles in Kazakhstan; however, data on their parasitic fauna are scarce. This study aimed to assess the diversity, prevalence, and genetic characteristics of endoparasite...

  • Review
  • Open Access
2 Citations
5,768 Views
20 Pages

Harnessing the Power of Microbiota: How Do Key Lactobacillus Species Aid in Clearing High-Risk Human Papilloma Virus Infection and Promoting the Regression of Cervical Dysplasia?

  • Edyta Kęczkowska,
  • Joanna Wrotyńska-Barczyńska,
  • Aneta Bałabas,
  • Magdalena Piątkowska,
  • Michalina Dąbrowska,
  • Paweł Czarnowski,
  • Ewa E. Hennig,
  • Maciej Brązert,
  • Piotr Olcha and
  • Natalia Zeber-Lubecka
  • + 1 author

19 August 2025

Lactobacillus species play a fundamental role in maintaining a healthy vaginal microbiota and have been increasingly recognized for their protective effects against high-risk human papillomavirus (HR-HPV) infection and the progression of cervical int...

  • Article
  • Open Access
1 Citations
1,520 Views
18 Pages

Passive eDNA Sampling Characterizes Fish Community Assembly in the Lancang River of Yunnan, China

  • Li Ding,
  • Xinbin Duan,
  • Mingdian Liu,
  • Daqing Chen,
  • Xiaofeng Huang,
  • Dengqiang Wang,
  • Baoshan Ma,
  • Shijian Fu and
  • Liqiao Zhong

19 August 2025

This study aimed to determine the practical efficacy of passive eDNA samplers (PEDS) for monitoring fish diversity in riverine ecosystems. It investigated the utility of environmental DNA (eDNA) in accurately depicting fish composition and diversity...

  • Article
  • Open Access
1,403 Views
19 Pages

18 August 2025

The overall survival of hepatocellular carcinoma (HCC) remains poor, highlighting the need for better prognostic tools. Nucleotide metabolism fuels tumor progression, while the immune microenvironment dictates therapy response, but integrated models...

  • Article
  • Open Access
1,303 Views
25 Pages

18 August 2025

Branched glycerol dialkyl glycerol tetraethers (brGDGTs) are promising molecular biomarkers widely applied in paleoenvironmental reconstructions, including temperature and pH. However, knowledge of the microorganisms responsible for brGDGT production...

  • Review
  • Open Access
4 Citations
5,742 Views
29 Pages

The Sublethal Effects of Neonicotinoids on Honeybees

  • Zunair Ahsan,
  • Zhijia Wu,
  • Zheguang Lin,
  • Ting Ji and
  • Kang Wang

18 August 2025

Honeybees (Apis mellifera) are indispensable pollinators vital to global biodiversity, ecosystem stability, and agricultural productivity, and they promote over 35% of food crops and 75% of flowering plants. Yet, they are in unprecedented decline, pa...

  • Review
  • Open Access
1,974 Views
20 Pages

From Panels to Pathogen Networks: The Expanding Role of Targeted Sequencing in Veterinary Medicine

  • Jiali Luo,
  • Wentao Lu,
  • Ruiting Liu,
  • Shukai Zhang,
  • Jie Cao and
  • Chong Ma

18 August 2025

Targeted sequencing, a pivotal branch of next-generation sequencing (NGS), enables the selective enrichment of specific genomic regions and has demonstrated significant advantages in the detection of animal pathogens. This review systematically explo...

  • Article
  • Open Access
1,170 Views
18 Pages

Evaluation of Bacterial Population Changes and Ecological Dynamics in Oil-Impacted Soils Using 16S rRNA Amplicon Sequencing

  • Teddie O. Rahube,
  • Ramganesh Selvarajan,
  • Batendi Nduna,
  • Bokani Nthaba,
  • Loago Molwalefhe and
  • Elisha Shemang

18 August 2025

Soils are vibrant and diverse natural entities situated at the juncture between Earth, air, water, and life [...]

  • Article
  • Open Access
1,601 Views
20 Pages

Ex Vivo Characterization of Peritoneal Macrophages from Novel ABCA1-LSL and ABCG1-LSL Mice for Macrophage-Specific ABC-Transporter Overexpression

  • Jing Echesabal-Chen,
  • Lawrence Fernando,
  • Ally Brawner,
  • Achala Pokhrel,
  • Kun Huang,
  • Rhonda Reigers Powell,
  • Terri Bruce,
  • Jan Guz,
  • Fu-Lei Tang and
  • Alexis Stamatikos
  • + 1 author

18 August 2025

We aimed to characterize peritoneal macrophages from two novel mouse models that enable macrophage-specific overexpression of ABCA1 and ABCG1 via Cre recombinase. Since ABCA1/ABCG1 expression in macrophages is acknowledged to be anti-atherogenic, ove...

  • Review
  • Open Access
1 Citations
4,777 Views
17 Pages

18 August 2025

Cocaine use remains a major public health concern, with rising global prevalence and a well-established profile of neurotoxicity and addictive potential. While the central nervous system has been the primary focus of cocaine research, emerging eviden...

  • Article
  • Open Access
1 Citations
1,361 Views
19 Pages

Assessing the Potential Distribution of the Traditional Chinese Medicinal Plant Spatholobus suberectus in China Under Climate Change: A Biomod2 Ensemble Model-Based Study

  • Yijun Lin,
  • Quanwei Liu,
  • Shan Lv,
  • Xiaoyu Huang,
  • Chaoyang Wei,
  • Jun Li,
  • Yijie Guan,
  • Yaxuan Pan,
  • Yijia Mi and
  • Danping Xu
  • + 2 authors

17 August 2025

Spatholobus suberectus, a valuable Chinese medicinal plant, faces habitat shifts under climate change. In order to better utilize the medicinal properties of S. suberectus and conduct further investigations, this study utilized the Biomod2 ensemble m...

  • Article
  • Open Access
771 Views
18 Pages

17 August 2025

Pinus yunnanensis is an essential tree species in southwest China. However, its genetic degeneration problem urgently needs to be addressed. Decapitation promotes seedling propagation primarily by disrupting apical dominance, triggering hormonal chan...

  • Review
  • Open Access
3 Citations
2,121 Views
25 Pages

Mapping Multi-Modal Fatigue in Elite Soccer Through Sweat-Omics Perspectives: A Narrative Review

  • Moses Gnanasigamani,
  • Ersan Arslan,
  • Yusuf Soylu,
  • Bulent Kilit and
  • Paweł Chmura

16 August 2025

Fatigue in elite soccer is a multifaceted phenomenon involving physical, metabolic, psychological, and neuromuscular stressors that accumulate over training and competition. Traditional monitoring tools, while informative, are often invasive, impract...

  • Review
  • Open Access
3 Citations
2,978 Views
34 Pages

Mimicking Gastric Cancer Collagen Reorganization with Decellularized ECM-Based Scaffolds

  • Néstor Corro,
  • Sebastián Alarcón,
  • Ángel Astroza,
  • Roxana González-Stegmaier and
  • Carolina Añazco

16 August 2025

The tumor microenvironment (TME) has a substantial impact on the progression of gastric cancer. Collagen, the most abundant protein in the extracellular matrix (ECM), forms a dense physical barrier that regulates anti-tumor immunity in the TME. It is...

  • Brief Report
  • Open Access
950 Views
8 Pages

A Genome-Wide Association Study of Rib Number and Thoracolumbar Vertebra Number in a Landrace × Yorkshire Crossbred Pig Population

  • Chunyan Bai,
  • Junwen Fei,
  • Xiaoran Zhang,
  • Wuyang Liu,
  • Juan Ke,
  • Changyi Chen,
  • Yu He,
  • Shuang Liang,
  • Boxing Sun and
  • Hao Sun

16 August 2025

The number of thoracolumbar vertebrae (NTLV) and the number of ribs (NR) are economically important traits in pigs due to their influence on carcass length and meat yield. Although VRTN is an established key gene, it fails to fully account for popula...

  • Article
  • Open Access
1,029 Views
19 Pages

Genetic Signatures of Competitive Performance in Burmese Gamecocks: A Transcriptomic Analysis

  • Supawadee Piratae,
  • Chanistha Yamtubtim,
  • Thanitaporn Nonsri,
  • Panpanit Poomprasert and
  • Tarid Purisotayo

16 August 2025

Understanding the genetic basis of high-performance animals is vital for biological insight and breeding. This study aimed to identify genetic factors distinguishing champion gamecocks (Gallus gallus domesticus) from less successful ones, representin...

  • Article
  • Open Access
1 Citations
4,510 Views
27 Pages

16 August 2025

Background/Objectives: Autism spectrum disorder is a psychological condition characterized by symptoms such as repetitive stereotypic behaviors and social interaction/communication difficulties. It is known that omega-3 deficiency during brain matura...

  • Article
  • Open Access
2,449 Views
32 Pages

Burdock Tea Affects Pulmonary Microbiota and Physiology Through Short-Chain Fatty Acids in Wistar Rats

  • Xiao-Feng Peng,
  • Jing-Yi Zhu,
  • Li-Zhi Cheng,
  • Wan-Hong Wei,
  • Sheng-Mei Yang and
  • Xin Dai

16 August 2025

The impact of burdock tea (BT) made from burdock (Arctium lappa) roots in normal individuals and animal models remains largely unknown, particularly on lung protection. This study examined responses of oxidative stress, inflammation, and the microbio...

  • Article
  • Open Access
1 Citations
897 Views
18 Pages

Comparative Enzymatic and Gene Expression Responses in Wheat to DON- and NIV-Producing Fusarium Species

  • Gabriela da Rocha Lemos Mendes,
  • Paulo Cesar Pazdiora,
  • Vivian Ebeling Viana,
  • Leandro José Dallagnol,
  • Laura Christina Calgaro,
  • Glacy Jaqueline da Silva,
  • Emerson Medeiros Del Ponte and
  • Antônio Costa de Oliveira

16 August 2025

Fusarium head blight (FHB) is a major threat to wheat production that is caused by toxigenic species of the Fusarium graminearum complex. This study aimed to investigate the biochemical and molecular defense responses of Brazilian wheat genotypes (BR...

  • Review
  • Open Access
1 Citations
2,609 Views
20 Pages

Targeting Ferroptosis: Emerging Insights into Osteoporosis Mechanisms

  • Hailing Yang,
  • Kang Ru,
  • Shuai Liu,
  • Chunyu Zhu,
  • Airong Qian and
  • Zhihao Chen

15 August 2025

Ferroptosis, a distinct form of programmed cell death characterized by iron-dependent lipid peroxidation, has emerged as a critical factor in the pathogenesis of various diseases. Given the increasing prevalence of osteoporosis worldwide and the incr...

  • Article
  • Open Access
2 Citations
1,121 Views
22 Pages

Forecasting Northward Range Expansion of Switchgrass in China via Multi-Scenario MaxEnt Simulations

  • Yangzhou Xiang,
  • Suhang Li,
  • Qiong Yang,
  • Jun Ren,
  • Ying Liu,
  • Yang Luo,
  • Ling Zhao,
  • Xuqiang Luo,
  • Bin Yao and
  • Xinzhao Guo

15 August 2025

Global warming is accelerating the poleward and upward shifts in climatically suitable ranges of species. Panicum virgatum (switchgrass) is recognized for its dual value in China’s dual-carbon strategy: mitigating food–energy land competi...

  • Article
  • Open Access
1 Citations
8,530 Views
22 Pages

Menstrual Cycle Phase Influences Cognitive Performance in Women and Modulates Sex Differences: A Combined Longitudinal and Cross-Sectional Study

  • Angelika K. Sawicka,
  • Katarzyna M. Michalak,
  • Barbara Naparło,
  • Adrià Bermudo-Gallaguet,
  • Maria Mataró,
  • Pawel J. Winklewski and
  • Anna B. Marcinkowska

15 August 2025

Sex hormones’ and menstrual cycle’s effects on cognitive performance remain unclear. This study examined cognitive differences between women across menstrual cycle phases, sex differences between women and men, and hormone–cognition...

  • Article
  • Open Access
1 Citations
903 Views
19 Pages

15 August 2025

In chickens, meat yield is a crucial trait in breeding programs. Identifying key molecular markers associated with increased muscle yield is essential for breeding strategies. This study applied transcriptome sequencing and machine learning methods t...

  • Article
  • Open Access
3 Citations
1,615 Views
21 Pages

Divergent Hepatic and Adipose Tissue Effects of Kupffer Cell Depletion in a Male Rat Model of Metabolic-Associated Steatohepatitis

  • Morena Wiszniewski,
  • Diego Mori,
  • Silvia I. Sanchez Puch,
  • Camila Martinez Calejman,
  • Cora B. Cymeryng and
  • Esteban M. Repetto

15 August 2025

Kupffer cells (KCs) play a pivotal role in the progression of metabolic-associated steatohepatitis (MASH). This study evaluated the impact of short-term KC depletion induced by gadolinium chloride (GdCl3) in a rat model of MASH. The intervention with...

  • Article
  • Open Access
954 Views
20 Pages

15 August 2025

Mediterranean ecosystems have been grazed by livestock for thousands of years. While considered both a major anthropogenic stressor and a potential habitat conservation tool, the effects of livestock grazing on vertebrate populations remain poorly un...

  • Article
  • Open Access
1,377 Views
26 Pages

15 August 2025

Tenrecs are heterothermic burrowing mammals, which are capable of withstanding extreme environmental stressors, including during hibernation. Their phylogenetic position as reminiscent of an ancestral placental mammal makes tenrecs a unique model for...

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