Biology, Volume 14, Issue 8
2025 August - 201 articles
RESEARCH CHALLENGES IN STAGE III AND IV RAS-ASSOCIATED CANCERS
Cover Story: Mutations in KRAS, HRAS, and NRAS transform essential regulators of cell growth into potent cancer drivers, especially in advanced disease. These altered Ras proteins rewire pathways like MAPK and PI3K, fueling tumor growth, adaptability, and drug resistance. Drawing from human, mouse, and Drosophila models, our review maps where normal Ras biology diverges into tumorigenic complexity. We examine why decades of targeted strategies have fallen short and highlight the need for physiologically relevant models that can keep pace with tumor evolution, paving the way for more effective therapies against RAS-driven cancers. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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