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Mitochondria’s Role in Skin Ageing

Dermatological Sciences, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
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Biology 2019, 8(2), 29; https://doi.org/10.3390/biology8020029
Received: 21 December 2018 / Revised: 5 February 2019 / Accepted: 7 February 2019 / Published: 11 May 2019
(This article belongs to the Special Issue Mitochondrial Dysfunction in Ageing and Diseases of Ageing)
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Abstract

Skin ageing is the result of a loss of cellular function, which can be further accelerated by external factors. Mitochondria have important roles in skin function, and mitochondrial damage has been found to accumulate with age in skin cells, but also in response to solar light and pollution. There is increasing evidence that mitochondrial dysfunction and oxidative stress are key features in all ageing tissues, including skin. This is directly linked to skin ageing phenotypes: wrinkle formation, hair greying and loss, uneven pigmentation and decreased wound healing. The loss of barrier function during skin ageing increases susceptibility to infection and affects wound healing. Therefore, an understanding of the mechanisms involved is important clinically and also for the development of antiageing skin care products. View Full-Text
Keywords: mitochondria; skin; ageing; reactive oxygen species; photoageing mitochondria; skin; ageing; reactive oxygen species; photoageing
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Stout, R.; Birch-Machin, M. Mitochondria’s Role in Skin Ageing. Biology 2019, 8, 29.

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