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Amyloidosis and Longevity: A Lesson from Plants

1
Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA
2
Division of Biomedical and Life Sciences, Faculty of Health and Medicine, University of Lancaster, Lancaster LA1 4AY, UK
3
Section of Otolaryngology, Department of Surgery, Yale School of Medicine, Yale University, New Haven, CT 06520, USA
*
Author to whom correspondence should be addressed.
Biology 2019, 8(2), 43; https://doi.org/10.3390/biology8020043
Received: 26 April 2019 / Revised: 16 May 2019 / Accepted: 22 May 2019 / Published: 24 May 2019
(This article belongs to the Section Biochemistry and Molecular Biology)
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PDF [2175 KB, uploaded 26 June 2019]
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Abstract

The variety of lifespans of different organisms in nature is amazing. Although it is acknowledged that the longevity is determined by a complex interaction between hereditary and environmental factors, many questions about factors defining lifespan remain open. One of them concerns a wide range of lifespans of different organisms. The reason for the longevity of certain trees, which reaches a thousand years and exceeds the lifespan of most long living vertebrates by a huge margin is also not completely understood. Here we have discussed some distinguishing characteristics of plants, which may explain their remarkable longevity. Among them are the absence (or very low abundance) of intracellular inclusions composed of amyloidogenic proteins, the lack of certain groups of proteins prone to aggregate and form amyloids in animals, and the high level of compounds which inhibit protein aggregation and possess antiaging properties. View Full-Text
Keywords: amyloidosis; protein aggregation; protein misfolding; longevity; lifespan; synucleins; neurodegeneration amyloidosis; protein aggregation; protein misfolding; longevity; lifespan; synucleins; neurodegeneration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Surguchov, A.; Emamzadeh, F.N.; Surguchev, A.A. Amyloidosis and Longevity: A Lesson from Plants. Biology 2019, 8, 43.

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