2026 August-2 - 113 articles
Age-associated mitochondrial decline reduces NAD+ availability, impairs oxidative phosphorylation (OXPHOS), and leads to accumulation of reactive oxygen species (ROS) thereby reshaping cellular metabolism. However, the regulatory logic coupling mitoc...
The population genetic diversity and demographic history of Hypomeces pulviger in Thailand were examined based on mitochondrial cytochrome c oxidase subunit 1 (CO1) and 16S ribosomal DNA (16S rDNA) sequence data. A total of 171 and 104 individuals fr...
Breast cancer (BRCA) possesses prominent molecular heterogeneity, where aberrant expression of genes annotated to asparagine metabolism networks drives malignant progression and therapeutic resistance. However, systematic construction of prognostic s...
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This study evaluated the effects of dietary LC inclusion (0, 50, 100, 200, and 400 mg/kg) in Pekin ducklings from 7 to 65 days of age on growth performance, carcass traits, metabolic profile, immune status, and economic efficiency. A total of 250 uns...
Among the many concerns surrounding global health, antimicrobial resistance (AMR) is widely recognized as a major threat, especially critical within livestock production, where restrictions on antibiotic use demand effective preventive alternatives....
Cuticular wax is a critical component of the plant cuticle, playing an indispensable role in plant growth, development, and defense against environmental stresses. ECERIFERUM3 (CER3), a very-long-chain fatty acyl-CoA reductase, serves as a pivotal hu...
Because human infertility can arise from genetic, molecular, cellular, anatomical, and endocrine abnormalities, in vitro gametogenesis has become an important area of reproductive research. New developing technology involving the generation of human...
During protein synthesis, ribosome stalling, collision, and aberrant elongation can lead to the accumulation of defective nascent polypeptides and compromise cellular homeostasis. To counteract such translational disturbances, eukaryotic cells have e...
Verticillium wilt, caused by Verticillium dahliae, is a major constraint on cotton production. The GASA (Gibberellic Acid-Stimulated in Arabidopsis) proteins are cysteine-rich peptides induced by gibberellin signaling; however, their systemic role in...
Anther development is a complex and highly regulated process essential for pollen formation and reproductive development. However, systematic identification of genes exhibiting anther-preferential expression patterns through multi-tissue transcriptom...
Death feigning (thanatosis) is the antipredator behaviour of grass snake (Natrix natrix) which can contribute to its survival. Since this is difficult to study under natural conditions, in our experiment we used four types of plasticine models of gra...
Aquaculture has emerged as one of the fastest-growing sectors of global food production, driven by population growth, consumer demand, and technological innovation. Despite this expansion, the industry continues to face persistent challenges, includi...
Melatonin is an important stress-protective agent in plant growth. Methyltransferase (ASMT) is an important enzyme in the concluding phase of melatonin production in plants. In this study, we performed the genome-wide identification and functional in...
Annamocarya sinensis is a Plant Species with Extremely Small Populations (PSESP) of great ecological and research value. Water conditions serve as a key environmental factor that profoundly shapes its growth, physiological homeostasis and stress adap...
Stipagrostis plumosa is a desert grass that remains relatively underexplored with respect to its phytochemical composition and biological activities, particularly against pathogens of veterinary relevance. This study aimed to characterize the phytoch...
Circular RNAs (circRNAs) participate in gene regulation and disease progression, but experimental mapping of circRNA-disease associations (CDAs) remains costly and incomplete. We developed NARVGA, a hybrid prediction framework that combines non-negat...
Physiology has long explained organismal stability through homeostasis, allostasis, feedback regulation, and related systems concepts. These frameworks remain essential, but each is most precise at a particular scale or mode of response. This manuscr...
The BTBR T+ Itpr3tf/J (BTBR) strain is a widely used model of neurodevelopmental disorders, characterized by an altered neuroanatomy, including a full-penetrant agenesis of the corpus callosum. While the adult BTBR brain has been studied thoroughly,...
Mitochondrial mechanisms are increasingly implicated in complex neurological conditions, including Autism Spectrum Disorder (ASD). Propionic acid (PPA) is widely used to study mitochondrial dysfunction in preclinical models of ASD. However, the molec...
Background: Elevated plasma homocysteine (HCY) is a risk factor for Alzheimer’s disease (AD), but its relationship with structural brain changes across the AD continuum remains unclear. The choroid plexus (CP) regulates cerebrospinal fluid home...
Cardiovascular disease causes the largest number of deaths across the world. The weak regenerative ability of adult hearts originates from limited cell proliferation and polyploidization of postnatal cardiomyocytes, which severely hinders tissue repa...
Epstein–Barr virus (EBV) is causally associated with various malignancies and autoimmune diseases. It establishes a lifelong latent infection in host B-lymphocytes, and can strategically manipulate host cell metabolism and cell-to-cell communic...
Bone-resident macrophages are increasingly recognized as regulators of bone metabolism, yet their contribution to primary human osteoblast cultures remains poorly understood. We investigated the functional relevance of CD14-positive cells in primary...
β-D-Xylosidases (BXLs) are members of glycoside hydrolase family 3. They play essential roles in cell wall remodeling, plant development, and abiotic stress responses. BXL gene families have been systematically characterized in several crop spec...
Interferons (IFNs) are a family of cytokines which serve as the first line of defense against pathogen infections while also exerting critical immunomodulatory roles. IFNs can induce hundreds of IFN-stimulated genes (ISGs) with cell-specificity, yet...
Most species within the genus Nicrophorus (Staphylinidae: Silphinae: Necrophorini) overwinter as adults during cold months. However, species that were once widely distributed, such as the American burying beetle, Nicrophorus americanus Olivier, exper...
Magnetic-field effects have been reported in controlled biological systems, but the relevance of weak geomagnetic variability to vegetation under natural conditions remains uncertain. We examined temporal associations between satellite-derived solar-...
Sulfur is an essential nutrient involved in plant growth, redox regulation, and responses to environmental stresses. Sulfate transporters (SULTRs) control sulfate uptake and distribution, thereby affecting sulfur availability for metabolic processes...
(1) Background: Drosophilid flies oviposit in damaged or fermenting substrates, whereas D. suzukii prefers to lay eggs in ripening fruits. This ecological shift requires females to recognize fruit-stage cues while overcoming the mechanical barrier im...
Background: Tinea capitis remains one of the most common superficial fungal infections in children worldwide and represents an important public health concern due to its high prevalence, potential complications, and changing epidemiology. This study...
Tobacco use remains one of the leading preventable causes of morbidity and mortality worldwide, contributing to more than 7 million deaths annually and imposing a substantial economic burden on healthcare systems and global productivity. The addictiv...
Syringaldehyde is a major lignin-derived inhibitor in lignocellulosic hydrolysates that affects growth, metabolism, and ethanol fermentation in Saccharomyces cerevisiae; however, the mechanisms underlying its toxicity and cellular adaptation remain p...
Although rice paddies are agricultural land, they also serve as artificial wetlands that deliver essential ecosystem services. Yet how farming systems affect their fish communities—and which metrics best capture those effects—remains poor...
Salt stress is an abiotic constraint on crop production, impairing growth while reducing yield and quality. As a source of edible oil and protein, soybean is particularly vulnerable to salt stress during emergence and seedling establishment, so the g...
Cold alpine salt-affected soils may retain carbon through mineral protection or suppressed microbial decomposition, but these processes remain difficult to distinguish. We measured soil physicochemical properties, four extracellular enzyme activities...
Charybdis (Gonioneptunus) bimaculata (Miers, 1886), C. (Charybdis) japonica (A. Milne-Edwards, 1861), and C. (Charybdis) miles (De Haan, 1835) are dominant target species harvested by small-scale artisanal fisheries in the coastal waters of China. Ch...
Skin is the outermost layer which covers all organs of the body. Skin can be divided into three layers, including epidermis, dermis and hypodermis. Similarly to many organs of the body, skin also experiences biological process that could not resist a...
Excessive abdominal fat deposition reduces the meat yield and feed conversion efficiency of meat ducks. To identify circRNAs associated with this trait, this study performed circRNA sequencing on abdominal fat tissue from fat-type (HF) and lean-type...
Tillage practices influence soil structural stability by modifying the soil physicochemical environment and biological processes. However, the relationships among tillage, soil depth, Glomalin-related soil proteins (GRSP), and soil aggregate stabilit...
Pine wilt disease is a devastating forest disease caused by Bursaphelenchus xylophilus infection. The associated bacterium Pseudomonas fluorescens and its flagellin protein have been implicated in this process, but the role of the flagellin-encoding...
Wolfram syndrome (WS) is a neurodegenerative disorder caused by mutations in the endoplasmic reticulum (ER) transmembrane protein WFS1. Mutations in WFS1 lead to ER stress and dysregulated calcium signaling, resulting in progressive neurological dysf...
Microbial remediation serves as a cost-effective and eco-friendly tactic for petroleum-contaminated sites. In real-world practices, petroleum-degrading microbial consortia display prominent superiority over single strains. To tap into their intrinsic...
Spinal pathologies, including degenerative disc disease, spinal cord injury, and conditions requiring spinal fusion, pose a substantial global health burden. While contemporary interventions provide symptomatic relief, achieving durable tissue repair...
This study evaluated the effects of replacing whole-plant corn silage with cotton stalk and sugar beet pulp mixed silage at 0, 30, 60, or 90% on growth performance, serum parameters, and rumen characteristics in Suffolk ram lambs, addressing the lack...
Frequent marine heatwaves (MHWs) pose significant threats to and have a profound impact on the structure and functioning of marine ecosystems. The response of marine organisms to MHWs may depend on the background temperature of their habitats. Saccha...
The seasonal development and overwintering success of Halyomorpha halys remain insufficiently resolved in temperate continental regions of southeastern Europe, where climatic conditions may permit more than one generation per year. We monitored seaso...
TCF3 fusion partner (TFPT) remains insufficiently characterized in hepatocellular carcinoma (HCC), particularly in relation to tumor growth and cellular features linked to lipid peroxidation defense. We integrated public transcriptomic and clinical d...
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have revolutionized the management of not only type 2 diabetes but also obesity. However, even with rapid therapeutic advances in GLP-1RAs, questions regarding the fundamental principles of GLP-1-m...
Elevated ammonia nitrogen significantly reduces the survival rate of Litopenaeus vannamei under low-salinity conditions. Low-salinity culture is widely adopted in shrimp farming but susceptible to ammonia accumulation; however, relevant studies mainl...
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