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Vaccines, Volume 13, Issue 5

May 2025 - 115 articles

Cover Story: Vaccines employing adenoviral (AdV) vector platforms such as human AdV (HAdV) and chimpanzee AdV (ChAdV) were pivotal in the fight against COVID-19. However, pre-existing vector immunity resulting from high natural prevalence and widespread use has limited their efficacy. The bovine AdV type 3 (BAdV-3) vector platform has emerged as a promising alternative in next-generation vaccine development. This platform offers key inherent attributes like high transduction efficiency, large transgene capacity, broad tissue tropism, suitability for intranasal administration, and strong innate and adaptive immune activation. Notably, it evades HAdV-specific immune responses and is nonpathogenic for its host. This review therefore explores the BAdV-3 vector’s potential as a versatile vaccine development platform for human and veterinary pathogens. View this paper
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Articles (115)

  • Article
  • Open Access
1,287 Views
22 Pages

Circulating Antibodies Against Common Cold Coronaviruses Do Not Interfere with Immune Responses to Primary or Booster SARS-CoV-2 mRNA Vaccines

  • Bindu Adhikari,
  • Eugene M. Oltz,
  • Richard J. Gumina,
  • Maryssa K. Kick,
  • Linda J. Saif and
  • Anastasia N. Vlasova

Background: Pre-existing cross-reactive antibodies (Abs) against common cold coronaviruses (CCCoVs) have been hypothesized to influence the immune responses to SARS-CoV-2 vaccine-induced Ab responses. Methods: Serum samples from healthy healthcare wo...

  • Review
  • Open Access
2 Citations
1,781 Views
16 Pages

Ocular Manifestations of Mpox and Other Poxvirus Infections: Clinical Insights and Emerging Therapeutic and Preventive Strategies

  • Yuan Zong,
  • Yaru Zou,
  • Mingming Yang,
  • Jing Zhang,
  • Zizhen Ye,
  • Jiaxin Deng,
  • Kyoko Ohno-Matsui and
  • Koju Kamoi

Poxvirus infections, particularly those caused by the monkeypox virus, have emerged as significant public health threats. Ocular manifestations constitute a severe potential clinical complication associated with these infections, potentially resultin...

  • Article
  • Open Access
945 Views
24 Pages

A Modified Variant of Fasciola hepatica FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

  • Riseilly Ramos-Nieves,
  • Albersy Armina-Rodriguez,
  • Maria Del Mar Figueroa-Gispert,
  • Ghalib Figueroa-Quiñones,
  • Carlimar Ocasio-Malavé and
  • Ana M. Espino

Background/Objectives: In the past, FhSAP-2, an 11.5 kDa recombinant protein belonging to the Fasciola hepatica saposin-like/NK-lysin family, has been shown to induce over 60% partial protection in immunized rabbits and mice when challenged with F. h...

  • Article
  • Open Access
1,016 Views
16 Pages

XBB.1.5 RBD-Based Bivalent Vaccines Induced Antibody Responses Against SARS-CoV-2 Variants in Mice

  • Jiawen Liu,
  • Tiantian Wang,
  • Hongying Ren,
  • Ruixi Liu,
  • Qian Wang,
  • Jun Wu and
  • Bo Liu

(1) Background: The currently circulating variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits resistance to antibodies induced by vaccines. The World Health Organization recommended the use of monovalent XBB.1 sublineages...

  • Article
  • Open Access
1 Citations
847 Views
10 Pages

Assessment of the Reversion to Virulence and Protective Efficacy in Pigs Receiving the Live Attenuated Classical Swine Fever Recombinant Vaccine Candidate FlagT4G

  • Elizabeth Ramirez-Medina,
  • Lauro Velazquez-Salinas,
  • Alyssa Valladares,
  • Ayushi Rai,
  • Leeanna Burton,
  • Leandro Sastre,
  • Ediane Silva,
  • Guillermo R. Risatti,
  • Llilianne Ganges and
  • Manuel V. Borca

Background/Objectives: Control of classical swine fever virus (CSFV) in endemic countries relies on vaccination using live attenuated vaccines (LAVs). Most of these LAVs do not allow for the differentiation of vaccinated animals from infected animals...

  • Review
  • Open Access
2 Citations
2,980 Views
16 Pages

Malaria Vaccines: Current Achievements and Path Forward

  • Jiayan Chen,
  • Qi Wang,
  • Xiaomeng He and
  • Bei Yang

Malaria remains a significant global health challenge. Although the recent approval of the liver-stage vaccines RTS, S and R21 marks significant progress in malaria control, challenges remain in achieving long-lasting and broad protection. In this re...

  • Article
  • Open Access
1,466 Views
14 Pages

Pneumococcal Vaccine Uptake in Adults Before and After Hospitalization for Pneumococcal Infections in Hong Kong, 2015 to 2024

  • King-Pui Florence Chan,
  • Ting-Fung Ma,
  • James Chung-Man Ho,
  • Ivan Fan-Ngai Hung,
  • Mary Sau-Man Ip and
  • Pak-Leung Ho

Background/Objectives: Vaccination is a key preventive measure against pneumococcal disease, but uptake rates remain low in high-risk populations. Limited information exists on pneumococcal vaccine uptake in individuals with a history of pneumococcal...

  • Article
  • Open Access
1,324 Views
15 Pages

Childhood Influenza Vaccination Is Not a Priority for Parents: A National, Cross-Sectional Survey of Barriers to Childhood Influenza Vaccination in Australia

  • Maryke S. Steffens,
  • Jessica Kaufman,
  • Katarzyna T. Bolsewicz,
  • Suzanna Vidmar,
  • Maria Christou-Ergos,
  • Majdi M. Sabahelzain,
  • Julie Leask,
  • Justin Boxall,
  • Frank Beard and
  • Margie Danchin

Background/objectives: Influenza vaccines are recommended and free in Australia for children aged <5 years, but uptake remains low at 25.8% compared to the targets of 40% and 50%. National data on barriers hindering paediatric influenza vaccinatio...

  • Brief Report
  • Open Access
805 Views
15 Pages

Persistent Low Anti-HIV Neutralizing Antibody Titers in HIV/HCV Coinfection Despite HCV Cure: A 5-Year Longitudinal Analysis

  • Daniel Sepúlveda-Crespo,
  • Víctor Sánchez-Merino,
  • Rafael Amigot-Sánchez,
  • Almudena Rubio-Pérez,
  • Cristina Díez,
  • Víctor Hontañón,
  • Juan Berenguer,
  • Juan González-García,
  • Felipe García and
  • Isidoro Martínez
  • + 2 authors

Background: Anti-HIV neutralizing antibodies (anti-HIV-nAbs) play a critical role in the immune defense against HIV by preventing viral entry and limiting replication. This study longitudinally evaluated the titers and variability of anti-HIV-nAbs in...

  • Article
  • Open Access
1 Citations
1,158 Views
15 Pages

Efficacy Evaluation of a VR-2332-Based Modified Live Vaccine Against NADC30-like PRRSV in China

  • Lixin Li,
  • Xiaxia Tong,
  • Jianhong Shu,
  • Huapeng Feng,
  • Yanping Quan and
  • Yulong He

Background: Porcine reproductive and respiratory syndrome is caused by PRRSV. Modified live vaccines (MLVs) are widely used to control PRRSV infection, but their efficacy against the emerging NADC30-like variant remains unclear. This study aimed to e...

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Vaccines - ISSN 2076-393X