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Vaccines, Volume 13, Issue 10

October 2025 - 86 articles

Cover Story: Orthoflaviviruses are transmitted by mosquitoes and ticks and include major human pathogens such as dengue, Zika, yellow fever, West Nile, and tick-borne encephalitis viruses. Although licensed vaccines exist for a limited number of orthoflaviviruses, their expanding geographic distribution, driven by climate change and urbanization, underscores the urgent need for vaccines with a high safety profile and providing broad and durable protection. This review outlines the strengths and limitations of current and emerging orthoflavivirus vaccine platforms and discusses how advances in antigen design, presentation, and delivery can inform the development of next-generation orthoflavivirus vaccines. View this paper
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Articles (86)

  • Review
  • Open Access
1,001 Views
17 Pages

21 October 2025

Influenza viruses, featured by high variability, pose a persistent public health threat because of an annual seasonal epidemic in the world and irregular global pandemic, requiring animal models to elucidate their pathogenic mechanisms and advance pr...

  • Article
  • Open Access
872 Views
22 Pages

Efficacy of a Novel PCV2d and Mycoplasma hyopneumoniae Combined Vaccine in Piglets with High and Low Levels of PCV2 Maternally Derived Antibodies at Vaccination

  • Mònica Sagrera,
  • Laura Garza-Moreno,
  • Àlex Cobos,
  • Anna Maria Llorens,
  • Eva Huerta,
  • Mónica Pérez,
  • Diego Pérez,
  • David Espigares,
  • Joaquim Segalés and
  • Marina Sibila

21 October 2025

Background/Objectives: Maternally derived antibody (MDA) levels of porcine circovirus 2 (PCV2) may eventually interfere with humoral response and vaccination efficacy. This study aimed to evaluate the efficacy of a ready-to-use PCV2d and Mycoplasma h...

  • Technical Note
  • Open Access
646 Views
24 Pages

Improving the Suitability of Vaccine Design for Immunisation Programmes and Enhancing Vaccine Policy Quality Through User Research

  • Stefano Malvolti,
  • Melissa Malhame,
  • Adam Soble,
  • Carsten Mantel,
  • Melissa Ko,
  • Lorena Perrin,
  • Tiziana Scarna,
  • Marion Menozzi-Arnaud and
  • Jean-Pierre Amorij

21 October 2025

Background: The achievement of the goals of the Immunization Agenda 2030 (IA2030) requires vaccines to be developed and implemented that meet the needs and requirements of the final users: vaccinators and vaccinees. A detailed and shared understandin...

  • Article
  • Open Access
784 Views
17 Pages

Impact of SARS-CoV-2 Vaccination on Disease Activity and Severity of COVID-19 Infection in Patients with Systemic Lupus Erythematosus: A Multicenter Cohort Study

  • Natália Sarzi Sartori,
  • Ketty Lysie Libardi Lira Machado,
  • Samira Tatiyama Miyamoto,
  • Flavia Zon Pretti,
  • Maria da Penha Gomes Gouveia,
  • Yasmin Gurtler Pinheiro de Oliveira,
  • Vanezia Gonçalves da Silva,
  • Filipe Faé,
  • Ana Paula Neves Burian and
  • Karina Rosemarie Lallemand Tapia
  • + 50 authors

21 October 2025

Background: To prospectively evaluate the safety and clinical impact of SARS-CoV-2 vaccines in patients with systemic lupus erythematosus (SLE). Methods: Subanalysis of the Brazilian multicenter observational study “Safety, Effectiveness and Du...

  • Review
  • Open Access
1,932 Views
13 Pages

Vaccination Against Herpes Zoster in Adults: Current Strategies in European Union Countries

  • Manuela Chiavarini,
  • Angela Bechini,
  • Sara Boccalini,
  • Alisa Barash,
  • Enrica Castellana,
  • Alessandro Senape and
  • Paolo Bonanni

20 October 2025

Background/Objectives: Herpes zoster (HZ), caused by varicella zoster virus (VZV) reactivation, significantly affects the functional status and quality of life of older adults and immunocompromised individuals. Vaccination represents an effective str...

  • Article
  • Open Access
628 Views
16 Pages

Efficacy Evaluation of an E2 Subunit Vaccine Against Highly Virulent Classical Swine Fever Virus Strain

  • Yu-Chieh Chen,
  • Chi-Chih Chen,
  • Wen-Bin Chung,
  • Yen-Li Huang,
  • Guan-Ming Ke and
  • Hso-Chi Chaung

20 October 2025

Background/Objectives: Classical swine fever (CSF) is listed by the World Organisation for Animal Health as a highly devastating and contagious pig disease, causing severe economic losses to the swine industry. In spite of the successful elimination...

  • Review
  • Open Access
1 Citations
1,302 Views
15 Pages

Global Transmission, Prevention, Control, and Treatment of Mpox Virus in 2025: A Comprehensive Review from Infection Mechanisms to Vaccine Development

  • Quan Quan,
  • Nan Wu,
  • Ying-Hua Luo,
  • Yan-Jun Tang,
  • Yan-Zhi Liu,
  • Xi-Chun Huang,
  • Jun-Hao Li,
  • Wan-Xia Ren and
  • Cheng-Hao Jin

20 October 2025

The World Health Organization (WHO) declared the mpox (MPX) outbreak a public health emergency of international concern (PHEIC) on 23 July 2022, and 14 August 2024, respectively, underscoring the confirmed and concerning global spread of the disease....

  • Systematic Review
  • Open Access
1,028 Views
34 Pages

Efficacy, Safety and Predictive Biomarkers of Oncolytic Virus Therapy in Solid Tumors: A Systematic Review and Meta-Analysis

  • Mohamed El-Tanani,
  • Syed Arman Rabbani,
  • Mohamed Anas Patni,
  • Rasha Babiker,
  • Shakta Mani Satyam,
  • Imran Rashid Rangraze,
  • Adil Farooq Wali,
  • Yahia El-Tanani and
  • Thantrira Porntaveetus

20 October 2025

Background: Oncolytic virus (OV) therapy couples direct tumor lysis with systemic immune priming, yet clinical benefit remains heterogeneous and the predictive biomarker landscape is poorly defined. We undertook a systematic review and meta-analysis...

  • Article
  • Open Access
753 Views
11 Pages

Demographic and Clinical Characteristics of Patients Vaccinated Against Herpes Zoster in a Primary Care Setting in Spain: A Retrospective Study

  • José María Blanc-Rodriguez-Arias,
  • Isabel Jimeno-Sanz,
  • Valentín Hernández-Barrera,
  • Alejandro Álvaro-Meca,
  • Manuel Torres-Ramos and
  • Ángel Gil-de-Miguel

20 October 2025

Background: Herpes zoster (HZ), commonly known as shingles, is a reactivation of the varicella-zoster virus that predominantly affects older adults and immunocompromised individuals. Vaccination with the recombinant zoster vaccine (RZV) has proven ef...

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Vaccines - ISSN 2076-393X