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Vaccines
Volume 13
Issue 5
10.3390/vaccines13050518
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Background:
Brief Report

Serological Correlate of Protection Established by Neutralizing Antibodies Differs Among Dialysis Patients with SARS-CoV-2 Variants of Concern

by
Guy Rostoker
1,2,*,
Stéphanie Rouanet
3,
Myriam Merzoug
1,
Hiba Chakaroun
4,
Mireille Griuncelli
1,
Christelle Loridon
1,
Ghada Boulahia
1 and
Luc Gagnon
5
1
Department of Nephrology and Dialysis, Hôpital Privé Claude Galien-Ramsay Santé, 91480 Quincy-sous-Sénart, France
2
Collège de Médecine des Hôpitaux de Paris, 75610 Paris, France
3
StatEthic, 92300 Levallois-Perret, France
4
Infection Prevention and Control Registered Nurse, Hôpital Privé Claude Galien-Ramsay Santé, 91480 Quincy-sous-Sénart, France
5
IQVIA Laboratories Vaccines, Laval, QC H7V 3S8, Canada
*
Author to whom correspondence should be addressed.
Vaccines 2025, 13(5), 518; https://doi.org/10.3390/vaccines13050518
Submission received: 24 March 2025 / Revised: 7 May 2025 / Accepted: 12 May 2025 / Published: 13 May 2025
(This article belongs to the Special Issue SARS-CoV-2 Variants, Vaccines, and Immune Responses)
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Abstract

Background: The 2019 coronavirus disease (COVID-19) pandemic had a severe impact on frail, end-stage kidney disease (ESKD) patients, either on dialysis or transplanted, with a high mortality rate in the early waves. Vaccination against SARS-CoV-2 with mRNA vaccines has led to reduced hospitalization and mortality rates in the general population and ESKD patients. Neutralizing antibodies (NAbs) are a valuable correlate of protection after vaccination, and IgG anti-spike antibodies are considered a surrogate marker of protection. Methods: This study investigated the correlates of protection brought by NAb and anti-spike IgG antibodies against SARS-CoV-2 wild-type Wuhan strain and variants of concern in a cohort of 128 French patients on dialysis after vaccination with the BNT162b2 mRNA vaccine. The correlate was assessed using Receiver Operating Characteristic curves. Results: The level of protection for IgG anti-spike antibodies was set at 917 BAU/mL for the original Wuhan strain and 980 BAU/mL and 1450 BAU/mL, respectively, for the Delta and Omicron BA.1 variants. Conclusions: The level of protection can be regularly monitored by measuring IgG anti-spike antibody concentrations to allow tailored boosters of SARS-CoV-2 vaccination in this frail and immunocompromised ESKD population.
Keywords: anti-spike IgG antibodies; correlate of protection; dialysis; neutralizing antibodies; SARS-CoV-2 variants of concern anti-spike IgG antibodies; correlate of protection; dialysis; neutralizing antibodies; SARS-CoV-2 variants of concern

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MDPI and ACS Style

Rostoker, G.; Rouanet, S.; Merzoug, M.; Chakaroun, H.; Griuncelli, M.; Loridon, C.; Boulahia, G.; Gagnon, L. Serological Correlate of Protection Established by Neutralizing Antibodies Differs Among Dialysis Patients with SARS-CoV-2 Variants of Concern. Vaccines 2025, 13, 518. https://doi.org/10.3390/vaccines13050518

AMA Style

Rostoker G, Rouanet S, Merzoug M, Chakaroun H, Griuncelli M, Loridon C, Boulahia G, Gagnon L. Serological Correlate of Protection Established by Neutralizing Antibodies Differs Among Dialysis Patients with SARS-CoV-2 Variants of Concern. Vaccines. 2025; 13(5):518. https://doi.org/10.3390/vaccines13050518

Chicago/Turabian Style

Rostoker, Guy, Stéphanie Rouanet, Myriam Merzoug, Hiba Chakaroun, Mireille Griuncelli, Christelle Loridon, Ghada Boulahia, and Luc Gagnon. 2025. "Serological Correlate of Protection Established by Neutralizing Antibodies Differs Among Dialysis Patients with SARS-CoV-2 Variants of Concern" Vaccines 13, no. 5: 518. https://doi.org/10.3390/vaccines13050518

APA Style

Rostoker, G., Rouanet, S., Merzoug, M., Chakaroun, H., Griuncelli, M., Loridon, C., Boulahia, G., & Gagnon, L. (2025). Serological Correlate of Protection Established by Neutralizing Antibodies Differs Among Dialysis Patients with SARS-CoV-2 Variants of Concern. Vaccines, 13(5), 518. https://doi.org/10.3390/vaccines13050518

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