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Vaccines, Volume 13, Issue 4

April 2025 - 98 articles

Cover Story: This review provides a comprehensive overview of adenoviral (Ad) vector-based COVID-19 vaccines, exploring their biology, structure, immune responses, and clinical applications. It highlights the advantages of Ad vectors, such as strong immunity and scalable production, while addressing challenges like preexisting vector immunity and reduced efficacy against emerging variants. The review sheds light on innovative strategies, including vector redesign, alternative delivery methods, and multivalent approaches to enhance immune coverage and durability. It also emphasizes the need for next-generation Ad vaccines to ensure global preparedness against emerging SARS-CoV-2 variants. View this paper
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Articles (98)

  • Review
  • Open Access
4 Citations
3,544 Views
17 Pages

Chronicling the Journey of Pneumococcal Conjugate Vaccine Introduction in India

  • Pawan Kumar,
  • Arindam Ray,
  • Amrita Kumari,
  • Abida Sultana,
  • Rhythm Hora,
  • Kapil Singh,
  • Rashmi Mehra,
  • Amanjot Kaur,
  • Seema Singh Koshal and
  • Syed F. Quadri
  • + 2 authors

21 April 2025

Background: Globally, pneumonia claims the lives of about 700,000 children under the age of 5 every year. Pneumococcal conjugate vaccine (PCV) was introduced in India phase-wise, beginning in high-burden states, and the rollout was completed nationwi...

  • Review
  • Open Access
6 Citations
4,193 Views
36 Pages

Viral Infections in Elderly Individuals: A Comprehensive Overview of SARS-CoV-2 and Influenza Susceptibility, Pathogenesis, and Clinical Treatment Strategies

  • Yanhao Huang,
  • Shumin Li,
  • Wenjie Ye,
  • Haoyun Wang,
  • Jun Su,
  • Lijuan Gao,
  • Ruohu Shi,
  • Xinyi Mou,
  • Sean Xiao Leng and
  • Chanchan Xiao
  • + 1 author

21 April 2025

As age increases, the immune function of elderly individuals gradually decreases, increasing their susceptibility to infectious diseases. Therefore, further research on common viral infections in the elderly population, especially severe acute respir...

  • Article
  • Open Access
1 Citations
1,348 Views
11 Pages

Intranasal Sendai Virus Vaccination of Seropositive Children 1 to 2 Years of Age in a Phase I Clinical Trial Boosts Immune Responses Toward Human Parainfluenza Virus Type 1

  • Elisabeth Adderson,
  • Kim J. Allison,
  • Kristen Branum,
  • Robert E. Sealy,
  • Bart G. Jones,
  • Sherri L. Surman,
  • Rhiannon R. Penkert,
  • Randall T. Hayden,
  • Charles J. Russell and
  • Allen Portner
  • + 2 authors

19 April 2025

Background/Objectives: Human parainfluenza virus type 1 (hPIV-1) is a major cause of serious respiratory diseases in young children. Annually, hPIV-1 results in approximately 10,000 hospitalizations in the United States due to croup, bronchiolitis, a...

  • Review
  • Open Access
2,572 Views
14 Pages

Intratumoral Immunotherapy in Breast Cancer

  • Camille C. Baumrucker,
  • Nicole Harris,
  • Susan Hoover and
  • Brian J. Czerniecki

19 April 2025

Breast cancer remains the most frequently diagnosed cancer and the second highest cause of cancer death in females. Metastatic recurrence that is resistant to traditional therapies presents a major challenge, necessitating the development of an innov...

  • Article
  • Open Access
1 Citations
2,639 Views
20 Pages

Design and Preliminary Immunogenicity Evaluation of Nipah Virus Glycoprotein G Epitope-Based Peptide Vaccine in Mice

  • Seungyeon Kim,
  • Rochelle A. Flores,
  • Seo Young Moon,
  • Seung Yun Lee,
  • Bujinlkham Altanzul,
  • Jiwon Baek,
  • Eun Bee Choi,
  • Heeji Lim,
  • Eun Young Jang and
  • Yoo-kyoung Lee
  • + 2 authors

18 April 2025

Background: The emergence of several paramyxoviruses, including Nipah virus (NiV), makes continued efforts in vaccine development as part of pandemic preparedness efforts necessary. Although NiV is a zoonotic pathogen with high case fatality, there i...

  • Article
  • Open Access
890 Views
10 Pages

Characterization of Cellular and Humoral Immunity to Commercial Cattle BVDV Vaccines in White-Tailed Deer

  • Paola M. Boggiatto,
  • Mitchell V. Palmer,
  • Steven C. Olsen and
  • Shollie M. Falkenberg

18 April 2025

Background/Objectives: White-tailed deer (Odocoileus virginianus) (WTD) play a central role at the human–livestock–wildlife interface, given their contribution to the spread of diseases that can affect livestock. These include a variety o...

  • Article
  • Open Access
1,537 Views
16 Pages

Low Antibody-Dependent Enhancement of Viral Entry Activity Supports the Safety of Inactivated SARS-CoV-2 Vaccines

  • Xiaofang Peng,
  • Yuru Han,
  • Song Xue,
  • Yunjiao Zhou,
  • Weiyu Jiang,
  • Anqi Xia,
  • Wei Wu,
  • Yidan Gao,
  • Fan Wu and
  • Qiao Wang

18 April 2025

Background/Objectives: The antibody-dependent enhancement (ADE) of viral entry has been documented for SARS-CoV-2 infection both in vitro and in vivo. However, the potential for the SARS-CoV-2 vaccination to elicit similar ADE effects remains unclear...

  • Article
  • Open Access
2 Citations
1,739 Views
13 Pages

Evaluating HPV Vaccination Behavior and Willingness to Be Vaccinated and Associated Factors Among University Students in Italy

  • Francesca Licata,
  • Concetta Arianna Scicchitano,
  • Maria Rita Caracciolo and
  • Aida Bianco

18 April 2025

Objectives: The aim of the present study was to provide insight into potential predictors of HPV vaccination uptake and the willingness to get vaccinated. Methods: This cross-sectional study was conducted among university students using an online, an...

  • Review
  • Open Access
14 Citations
11,027 Views
50 Pages

Beyond the Pandemic Era: Recent Advances and Efficacy of SARS-CoV-2 Vaccines Against Emerging Variants of Concern

  • Ankita Saha,
  • Sounak Ghosh Roy,
  • Richa Dwivedi,
  • Prajna Tripathi,
  • Kamal Kumar,
  • Shashank Manohar Nambiar and
  • Rajiv Pathak

17 April 2025

Vaccination has been instrumental in curbing the transmission of SARS-CoV-2 and mitigating the severity of clinical manifestations associated with COVID-19. Numerous COVID-19 vaccines have been developed to this effect, including BioNTech-Pfizer and...

  • Article
  • Open Access
1 Citations
2,239 Views
16 Pages

17 April 2025

Background/Objectives: Porcine epidemic diarrhea (PED) is a highly contagious enteric infectious disease that causes severe morbidity and mortality in piglets, posing significant economic losses to the swine industry worldwide. Oral vaccines based on...

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Vaccines - ISSN 2076-393X