2026 July - 217 articles
Fusobacterium nucleatum (F. nucleatum) is a key periodontal pathobiont associated with oral inflammation. This bacterium forms biofilms and expresses adhesins that facilitate its adhesion to and invasion of gingival epithelial cells. These processes...
Natural inland saline–alkaline wetlands offer opportunities for evaluating microbial responses to long-term salinity stress. This study examined surface soils from non-saline, moderately saline, and hypersaline sites in the Luyang Lake wetland,...
Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious threat to public health and can form biofilms to enhance its drug resistance. Caffeic acid phenethyl ester (CAPE), which is primarily extracted from propolis, possesses diverse biolog...
Cotton Verticillium wilt is a devastating fungal disease caused by Verticillium dahliae, and biological control has become a safe and efficient strategy for its green prevention and control. In this study, the endophytic strain Bacillus velezensis BH...
Salinity poses a major threat to sustainable agriculture and coastal ecosystems, resulting in a substantial loss of plant productivity and biodiversity. Although some coastal grass species exhibit natural adaptation to saline conditions, the physiolo...
Ectropis obliqua nucleopolyhedrovirus (EcobNPV) is an important biocontrol agent against Ectropis obliqua and E. grisescens. A previously isolated strain, EcobNPV-QF4, exhibits significantly higher virulence than the original strain EcobNPV-QV, yet t...
Mumps virus (MuV) genotype G is widely represented among circulating strains, but the evolutionary patterns of the hemagglutinin–neuraminidase (HN) gene remain incompletely understood. In this study, we analyzed publicly available full-length g...
Nontuberculous mycobacteria (NTM) pose significant diagnostic challenges in high tuberculosis (TB)-burden settings, particularly when routine molecular assays suggest multidrug-resistant TB (MDR-TB). Current diagnostic algorithms in high TB-burden se...
Metagenomic analysis of extreme environments is essential in biotechnological research. This work aimed to determine and compare the microbial diversity of two Peruvian saline environments and characterise their functional profiles. Soil metagenomic...
Lactococcus lactis is an essential industrial “cell factory” used extensively in food fermentation and biotechnology. However, a critical biological question regarding the regulatory mechanisms of the microorganism’s adaptation proc...
Autophagy is a crucial mechanism in the host response to intracellular bacterial pathogens during which microorganisms may undergo direct degradation in autophagolysosomes. As a highly virulent intracellular pathogen, Francisella tularensis has devel...
Clustered regularly interspaced short palindromic repeats (CRISPR) are widespread in bacterial and archaeal genomes as an adaptive immune system against invading mobile genetic elements. This study investigated the distribution of CRISPR loci and the...
Lactic Acid Bacteria (LAB) and other starter cultures play key roles in fermented meat products by influencing fermentation, safety, sensory properties, and metabolite formation. Metabolomic approaches based mainly on mass spectrometry, including GC-...
Neurogenic bladder is a condition associated with impaired voiding, leading to urinary stasis and increased susceptibility to urinary tract infections, predominantly caused by Escherichia coli. In this context, bacterial iron acquisition systems repr...
Feeding animals with soybean meal (SBM) fermented by probiotics normally confers benefits. This study evaluated the growth-promoting effects of SBM fermented with Bacillus subtilis M2 (M2-FSBM), a probiotic strain with antimicrobial activity, as a re...
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health burden. Host genetic factors play a critical role in TB susceptibility, but the underlying mechanisms are not fully understood. Genome-wide association studi...
Monitoring individual strains in complex microbial communities remains a fundamental challenge in microbial ecology and biotechnology. Here, we present an integrated pipeline for identifying and validating strain-specific loci (SSL) in four biotechno...
Extraintestinal pathogenic Escherichia coli (ExPEC) causes severe infections in humans and animals, yet bovine isolates remain poorly characterized. Here, we report the first complete genome of a bovine ExPEC strain, BN01 (serotype O101:H9-ST10-phylo...
Bacteriophage exposure can impose strong selective pressure on bacterial populations and may alter antimicrobial susceptibility beyond direct lytic effects. However, the persistence of such changes after the removal of phage pressure remains insuffic...
Non-typhoidal Salmonella (NTS) remains a major cause of foodborne illness worldwide, and its persistence along the food-production continuum poses a significant public health challenge. Biofilm formation is an adaptive mechanism that enhances NTS sur...
Virulent phage vB_PmuP_Pa7 is a promising candidate for controlling Pasteurella multocida infection, yet the molecular basis of its lytic process remains poorly understood. Here, we performed strand-specific RNA sequencing on P. multocida S34 infecte...
Wastewater systems are critical reservoirs where antibiotic resistance genes, antibiotic-resistant bacteria, and pathogens converge and disseminate into receiving waters, posing risks to ecosystems and public health. Metagenomics enables culture-inde...
Litter-inhabiting fungi drive organic matter mineralization, regulate nutrient cycling, and support ecosystem stability. Understanding their dynamics in unique geological habitats is essential for predicting ecological recovery on volcanic landforms....
Soil microbial carbon use efficiency (CUE) and nitrogen use efficiency (NUE) are fundamental parameters governing organic matter turnover in terrestrial ecosystems, yet how forest type-driven variation in litter quality propagates through the litter&...
Isoniazid (INH) targets cell wall biosynthesis and is a potent antimycobacterial agent. Elucidating the regulatory networks that govern drug susceptibility in mycobacterial models is fundamental to understanding intrinsic resistance in pathogenic spe...
The need to transition from a fossil resource-based economy to a sustainable, circular bioeconomy has never been more urgent [...]
In the original publication [...]
Bacteria play a vital role in enhancing host resistance to salt–alkali stress. However, the composition and structure of bacterial communities associated with halophytes under natural high salt–alkali conditions remain poorly understood....
This study combined seasonal observation in Min pigs and acute cold challenge experiments in Min pigs and Large White pigs to analyze changes in gut butyrate synthesis under cold exposure and its association with thermogenesis. Compared with summer,...
Syndromic multiplex-PCR panels deliver rapid, comprehensive detection of pathogens and resistance determinants in acute infections, but their unrestricted use can generate a high proportion of negative results with substantial economic and stewardshi...
Multidrug-resistant (MDR) Klebsiella pneumoniae is a critical cause of nosocomial infections associated with high mortality. Of particular concern is the genomic convergence of multidrug resistance and hypervirulence (MDR-hvKP), which represents a se...
The mammalian respiratory system stands as a frontline barrier, constantly exposed to environmental insults, balancing defensive immunity with gas exchange. Historically considered sterile, the lung harbors a dynamic, low-biomass microbiome that evol...
Antarctic microorganisms experience persistent subzero temperatures and repeated freeze–thaw cycles that require specialized mechanisms for survival. Although transcriptomic studies have identified numerous cold-responsive genes, many remain an...
Viral metagenomics has fundamentally transformed how we investigate the virosphere [...]
Endophytic bacteria of the Bacillus subtilis species complex are known for plant growth promotion and antifungal activity, although strain-specific traits remain poorly understood. This study characterized the Bacillus siamensis strain BACIII, isolat...
Polygonatum kingianum Coll. (PKC) is a valuable medicinal herb native to Yunnan, China, but its yield and quality are severely threatened by root rot. To elucidate the rhizosphere microbial dynamics associated with this disease and to identify locati...
Leprosy presents a broad clinical–immunological spectrum, whose heterogeneity challenges early diagnosis and disease stratification. Metabolomic approaches have emerged as promising tools for identifying potential biomarkers associated with the...
Obesity is a chronic metabolic condition characterized by low-grade inflammation and oxidative imbalance and is strongly associated with impaired male reproductive function. This study investigated whether prebiotic–probiotic supplementation co...
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by epithelial barrier dysfunction, immune dysregulation, and marked clinical heterogeneity. Although sex hormones and gut microbiota have independently been implicated in AD...
Colorectal cancer (CRC) remains a major global health burden, and early detection through population-based screening programs significantly reduces both incidence and mortality. Although gut microbiome-based biomarkers have emerged as promising non-i...
Lyme borreliosis has been reported across China, but data on Borrelia burgdorferi sensu lato exposure in humans and infection in questing Ixodes ticks remains fragmented and heterogeneous. This systematic review and meta-analysis aimed to estimate th...
To develop green feed additives suitable for antibiotic-free livestock farming on the Qinghai–Tibet Plateau, this study used Lactobacillus salivarius TB2.1, isolated from Tibetan black pigs, and Lactobacillus agilis CW13.2, isolated from wild b...
Small non-coding RNAs (sRNAs) are ubiquitous post-transcriptional regulators that enable rapid bacterial adaptation to fluctuating environments. Previous reviews have largely focused on sRNA mechanisms in model organisms. This review integrates compu...
This study established three intercropping densities of cassava and chili (chili plant spacing of 0.4 m, 0.5 m, and 0.6 m, denoted as IA, IB, and IC, respectively), using cassava monoculture (MC) and chili monoculture (MP) as controls, to systematica...
Acute infectious gastroenteritis (AIG) is caused by diverse bacterial and viral enteric pathogens with overlapping clinical presentations, limiting conventional pathogen-directed workflows. This retrospective before–after study evaluated the di...
Global warming is profoundly altering the structure and function of permafrost peatland ecosystems, but how soil microorganisms as core regulators of biogeochemical cycles respond to the process remains unclear. We investigated peatlands of the conti...
African horse sickness (AHS), a noncontagious insect-borne disease affecting equids, is caused by the African horse sickness virus (AHSV) and is associated with extremely high morbidity and mortality. AHSV has nine distinct serotypes (AHSV-1 to AHSV-...
Hybrid biological–inorganic (HBI) systems that integrate hydrogen-oxidizing bacteria (HOBs) with inorganic water-splitting catalysts have been developed as bioelectrochemical platforms for CO2 conversion. This study used an HBI system to enrich...
Foodborne and waterborne pathogens remain major global public health concerns, affecting human health, animal health, food safety, water quality, environmental health, and economic stability [...]
Grazing disturbance strongly affects grassland ecosystem structure and function, but its impacts on soil protist communities across vertical soil profiles remain unclear in alpine grasslands. We investigated soil protist community composition, alpha...
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