2026 October - 288 articles
Feline panleukopenia (FP) is a highly fatal disease in cats caused by feline panleukopenia virus (FPV). The viral capsid protein VP2 determines immunogenicity and host range. We isolated an FPV strain, ZZ202501, and generated four monoclonal antibodi...
Infective endocarditis (IE) is a life-threatening disease in which rapid identification of the causative pathogen is essential for appropriate antimicrobial therapy. Although blood cultures remain the standard microbiological method, complementary mo...
The translation of microbiome therapeutics is hampered by the stochasticity of faecal microbiota transplantation (FMT), an empirical transfer of undefined biomass confounded by donor heterogeneity, procedural variability, and immunogenic debris. As t...
Mannan oligosaccharides (MOSs) are used as prebiotic feed additives, but their effects on lactating donkeys and their offspring remain poorly understood. This study evaluated the effects of maternal dietary MOS supplementation on milk composition, fo...
Tuberculosis (TB) remains a leading global infectious disease burden. The rising global burden of dysglycemia and dyslipidemia—which geographically converges with TB in many low- and middle-income countries—poses substantial challenges to...
Phage-derived endolysins are considered promising antibacterial agents for controlling bacterial pathogens. However, their activity against Gram-negative bacteria is usually limited by the outer membrane barrier. Salmonella enterica is a leading food...
We analyzed riverbed microbiota structure, gene expression, and fatty acid production across several sites along Little Miami River in Ohio, United States. The sites varied in stream width, shading, surrounding land use, and the size of the riparian...
The number of patients with long COVID continues to rise as COVID-19 persists, yet research on its implications for female reproductive health remains scarce. Long COVID is linked to an increased risk of abnormal uterine bleeding, heavier menstrual f...
The gut microbiome plays critical roles in nutrient metabolism and host adaptation in ruminants, yet genome-level functional differences in the fecal microbiomes across geographic populations of wild red deer remain underexplored. Here, we integrated...
In this study, viral metagenomics was applied to identify viruses related to the Dicistroviridae family in freshwater samples collected from urban reservoirs of the state of São Paulo, Brazil. Through next-generation sequencing, five complete...
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a global health threat driven by limited treatment options and high-risk clones. This study aimed to characterise the clonal structure, resistance and virulence determinants and carbapenemase-carry...
To investigate factors associated with multidrug resistance (MDR) in diabetes-related foot infections (DFIs), focusing on polymicrobial infection and glycated hemoglobin (HbA1c). This retrospective single-center study included culture-positive deep-t...
Since 2019, SARS-CoV-2 variants of concern (VOCs), Alpha, Gamma, Delta, and Omicron, have exhibited distinct transmissibility and severity profiles. In Brazil, Gamma caused high mortality pre-vaccination, yet its underlying pathological mechanisms re...
Among the substances and preparations used in bodybuilding as potential or auxiliary ergogenic agents, particular attention should be paid to plant-based, specifically turmeric, synephrine and yohimbine, preparations due to their known antimicrobial...
NagZ is a glycoside hydrolase that regulates AmpC β-lactamase and biofilm formation in Gram-negative bacteria, and its inhibitors show promise as antibiotic adjuvants. However, the role of nagZ in the important foodborne pathogen Yersinia entero...
To report epidemiological patterns of adenoviral keratoconjunctivitis at a tertiary care hospital in Switzerland from 2012 until 2025, particularly comparing incidence rates during the COVID-19 pandemic. A single-centre, retrospective, observational...
Bovine alphaherpesvirus 1 (BoAHV-1) is a major cattle pathogen, and glycoprotein E (gE)-negative marker vaccines are widely used for disease control and to differentiate infected from vaccinated animals. The genomic architecture of this previously de...
Salt-free lacto-fermentation is gaining attention owing to the global demand for sodium reduction. Sunki, a traditional unsalted Japanese turnip pickle, provides a unique ecological model. In this study, we investigated the microbial balance and syst...
Desert truffles are hypogeous edible fungi of ecological and economic importance in arid and semi-arid ecosystems, where they establish mycorrhizal associations with Helianthemum species. This study evaluated the effects of pH, culture medium, and fu...
Akkermansia muciniphila (AKK) is linked to intestinal barrier homeostasis, but whether live AKK can directly protect human colonic epithelium during a defined cytokine insult remains less clear. We tested this question in human primary colonic epithe...
Herpes zoster results from the reactivation of latent varicella-zoster virus and may cause serious complications. Although traditionally considered nonseasonal, recent studies have reported summer peaks in herpes zoster occurrence. Given these incons...
Antibiotic-, biocide-, and metal-resistance genes co-occur in the genomes of multidrug-resistant bacteria. This relationship is more complex than mere physical co-localization. Instead, it arises from co-selection pressures that favor co-regulation a...
Aspergillus flavus is a significant foodborne pathogen, responsible for food contamination and invasive aspergillosis. Isolating this pathogen is challenging because traditional media do not reflect the natural environment. In this study, we designed...
Biohythane has attracted growing interest as an eco-friendly biofuel. However, its production stability is often compromised by rapid acidification during the dark fermentation hydrogen production stage. Acidification intensifies proton competition b...
Cervical incompetence (CIC) represents a significant cause of preterm birth globally. Clinical symptoms of CIC are typically delayed until mid-to-late pregnancy, thereby imposing challenges in CIC diagnosis. There is evidence that the microbiota cont...
Helicobacter pylori (H. pylori) infection is a major global gastrointestinal health concern, and increasing antibiotic resistance has prompted interest in complementary probiotic strategies. In this study, Lactiplantibacillus plantarum SHY0008 isolat...
Human metapneumovirus genotype A (HMPV-A) comprises genetically diverse lineages, but whether F-gene diversification is accompanied by changes in the conserved fusion (F) protein remains unclear. We analyzed 500 PARNAS-selected HMPV-A F gene sequence...
Major depressive disorder (MDD) is a highly prevalent psychiatric illness worldwide, yet current therapeutic approaches still face challenges, including limited treatment efficacy, high interindividual variability, and high rates of treatment resista...
Oncolytic viruses (OVs) are increasingly viewed not only as tumor-lysing agents but also as immunotherapeutic platforms capable of functioning as in situ cancer vaccines. By selectively infecting malignant cells, inducing immunogenic cell death, rele...
Long-term monoculture degrades soil ecological conditions and is associated with severe wilt disease in Chrysanthemum morifolium. The effects of combining rapeseed biofumigation and biochar to alleviate these continuous cropping obstacles remain poor...
Anaerobic ammonium oxidation (anammox) is an energy-efficient and low-carbon process for nitrogen removal, but its wider application exposes anammox biomass to more complex contaminant mixtures. Existing reviews have examined contaminant inhibition a...
This study examined the effects of purified lovastatin (LV) obtained from Monascus fermentation on ruminal fermentation, methane production, and microbial communities during a 48-h in vitro incubation. A fattening-sheep diet containing concentrate an...
The escalating crisis of invasive fungal infections and increasing antifungal resistance demand rapid therapeutic innovation. Given the critically narrow clinical arsenal, artificial intelligence (AI) and machine learning (ML) have emerged as pivotal...
Respiratory syncytial virus (RSV) has emerged as a major cause of hospitalization among adults in the post-pandemic era. We studied the epidemiological findings and the outcomes of patients hospitalized with influenza or RSV during the first post-pan...
This study investigates the genomic and antibacterial potential of five Photorhabdus isolates recovered from Heterorhabditis sp. entomopathogenic nematodes collected from soil samples in northern Thailand (Kamphaengphet and Phitsanulok provinces). Wh...
Repurposing existing drugs offers an attractive strategy for neglected infectious diseases, but therapeutic efficacy may be limited by inadequate drug delivery to the site of infection. Imiquimod (IQ), a topical immunomodulatory agent, has shown pote...
The growing prevalence of multidrug-resistant Mycobacterium tuberculosis complicates tuberculosis control efforts. We discovered that Rv1453, as a new transcription factor, is crucial for lipid metabolism in bacteria. Rv1453 suppresses expression of...
Alpha-gal syndrome (AGS) is an emerging tick-associated allergy characterized by IgE-mediated hypersensitivity to galactose-α-1,3-galactose (α-gal). Although α-gal antigens have been identified in Amblyomma americanum salivary glands, the mechanisms...
Cycloviruses are circular Rep-encoding single-stranded DNA (CRESS-DNA) viruses detected in a wide range of biological and environmental samples, although the natural hosts and biological significance of many members of the genus remain poorly underst...
The integration of plant growth-promoting bacteria (PGPB) into sustainable agricultural practices represents a promising strategy for improving crop productivity and stress resilience. We characterized two newly isolated steppe-derived, glyphosate-to...
Streptococcus pyogenes (S. pyogenes) M1UK is an emergent emm1 lineage associated with increased production of the superantigen SpeA and has spread internationally. We report fatal post-influenza streptococcal toxic shock syndrome (STSS) caused by M1U...
Pneumocystis jirovecii pneumonia (PCP) remains a major cause of acute respiratory failure in immunocompromised patients and is increasingly encountered in critical care outside the traditional human immunodeficiency virus (HIV) population. This narra...
Calf diarrhea is frequently accompanied by disruption of the gastrointestinal microbiota, but the relationships between clinical status and microbial community composition, gene-content functional potential, and antimicrobial-resistance-associated fe...
Bacteria are continually exposed to stressors, making their ability to sense, acclimate and adapt to changing conditions essential for fitness. Two-component response systems (TCRS) play a primary role in mediating these responses. However, the role...
Antiretroviral therapy (ART) suppresses HIV replication but does not eliminate persistent viral reservoirs, which can rapidly reseed viremia following treatment interruption. We previously showed that blockade of transforming growth factor beta (TGF-...
Bacterial extracellular vesicles (EVs) have emerged as a relevant mode of communication between host and resident microbiota. Evidence is limited regarding the ability of Gram-positive EVs to interact with primary colonic epithelial cells. We propose...
While the One Health paradigm has successfully elevated antimicrobial resistance (AMR) on the global political agenda, its operationalization raises questions about how research, surveillance and interventions can best address transmission in healthc...
Mycobacterium tuberculosis (Mtb) infection can trigger immune responses in macrophages during its autophagy and apoptosis, as two crucial cellular processes which are essential for the host to clear the pathogen. Resveratrol (RES) is a natural polyph...
Organic fertilizers are rich in nutrients but also frequently contain multiple contaminants that pose a potential threat to the agricultural environment. However, comprehensive investigations into commercial organic fertilizers remain scarce. In this...
A novel Pseudomonas strain, designated S9268T, was isolated from the rhizosphere soil of wheat in Yongnian District, Handan City, Hebei Province, PR China. Cells were Gram-stain-negative, aerobic, rod-shaped, and motile by means of multiple polar fla...
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