Research on Antimicrobial Activity of Natural Products, Third Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 852

Special Issue Editors


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Guest Editor
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros de Leixões, AV. General Norton de Matos, s/n, 4450-208 Matosinhos, Portugal
Interests: bioprospection; actinobacteria; bioactive metabolites; discovery of new natural compounds
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Guest Editor
School of Health, Polytechnic Institute of Porto (ESS|P:PORTO), Porto, Portugal
Interests: health biotechnology; analytical chromatography; quantification of biomolecules; antimicrobial resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microbial infections are responsible for millions of deaths every year and worldwide. The increased resistance to antimicrobial drugs, such as antibiotics, is the main cause and is one of the biggest challenges in human and animal health and in food safety. It is well known that human pathogenic microorganisms resistant to major classes of antibiotics have increased due to the indiscriminate use of antimicrobial drugs. Therefore, the search for the discovery of new antimicrobial agents is in urgent demand.

Finding therapeutic powers in nature is an ancient but increasingly actual idea. In recent years, strategies to overcome the resistance of antibiotics have been suggested, namely the use of phytochemicals. Natural compounds have already proved to be effective and safe sources of antimicrobial compounds and eco-friendly methodologies focused on reducing the growth of pathogenic microorganisms. This Special Issue is directed to ethnopharmacologists, botanists, microbiologists, and natural-products chemists working on developing new approaches for the treatment of infectious diseases. Papers based on the investigation of new sources of natural antimicrobial compounds or mechanisms of action of natural compounds are most welcome.

Dr. Rosário Martins
Dr. Maria De Fátima Carvalho
Dr. Mónica Vieira
Guest Editors

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Keywords

  • antimicrobial activity
  • bacteria
  • cyanobacteria
  • fungi
  • antibiotic resistance
  • natural compounds

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Published Papers (1 paper)

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37 pages, 1390 KB  
Systematic Review
Unveiling Lichen’s Hidden Arsenal Against Multidrug Resistance: A Systematic Review of Their Essential Oils, Volatile Compounds and Extracts with Antimicrobial Applications
by Yasser Essadki, Soukaina El Amrani Zerrifi, Maria de Fátima Carvalho, Lillian Barros, Vitor Vasconcelos, Alexandre Campos, Fatima El Khalloufi, Brahim Oudra and Rosário Martins
Microorganisms 2026, 14(4), 924; https://doi.org/10.3390/microorganisms14040924 - 20 Apr 2026
Viewed by 565
Abstract
The increase in multidrug resistance in microorganisms and the rise of emergent infectious diseases worldwide is a threat to human and animal health. Therefore, research on new molecules with antibiotic potential is a priority. Lichens have a unique secondary metabolism with relatively untapped [...] Read more.
The increase in multidrug resistance in microorganisms and the rise of emergent infectious diseases worldwide is a threat to human and animal health. Therefore, research on new molecules with antibiotic potential is a priority. Lichens have a unique secondary metabolism with relatively untapped potential, yet their essential oils (EOs) and volatile organic compounds (VOCs) remain a relatively untapped resource. This systematic review was conducted following PRISMA 2020 guidelines, with a comprehensive search performed in the Web of Science database for studies published up to 2023. From 254 identified records, six studies involving nine lichen species (Evernia prunastri, Evernia divaricata, Cladonia rangiformis, Cladonia furcata, Parmotrema perlatum, Lichina pygmaea, Parmelia perlata, Hypogymnia physodes, and Parmelia sulcata) met the eligibility criteria. The synthesized data show that these volatile fractions possess significant antimicrobial potential, with minimum inhibitory concentrations (MICs) generally lower than 1 mg/mL. Major bioactive constituents identified include atraric acid, orsellinates, and various sesquiterpenes. While the current evidence highlights a strong potential of lichen volatiles against pathogens, research is limited to a small fraction of known species. This review identifies a critical gap in testing these compounds directly against MDR clinical isolates and suggests that future research should focus on high-biomass species and the heterologous expression of lichen biosynthetic genes to develop sustainable antimicrobial applications. Full article
(This article belongs to the Special Issue Research on Antimicrobial Activity of Natural Products, Third Edition)
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