Mycobacterium leprae, Mycobacterium lepromatosis and Leprosy Studies

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1134

Special Issue Editors


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Guest Editor
Anatomical Pathology Laboratory of Bauru (ANATOMED), Lauro de Souza Lima Institute (ILSL), Bauru 17034-971, Brazil
Interests: histopathology; dermatopathology and leprosy pathology

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Guest Editor
Anatomical Pathology Laboratory of Bauru (ANATOMED), Lauro de Souza Lima Institute (ILSL), Bauru 17034-971, Brazil
Interests: drug resistance; in vivo models for leprosy

E-Mail Website
Guest Editor
Pathology Unit, Hospital of Clinics, Federal University of Uberlândia, Brazilian Company for Hospital Services (HC-UFU/EBSERH), Uberlândia, MG, Brazil
Interests: leprosy pathology; skin and nerve biopsy; leprosy relapse; treatment failure; leprosy reactions; leprosy metabolomics

Special Issue Information

Dear Colleagues,

The Special Issue entitled “Mycobacterium lepraeMycobacterium lepromatosis and Leprosy Studies” aims to present recent research on a wide range of topics related to leprosy, a complex disease that mainly affects people living in developing countries. People exposed to Mycobacterium leprae or Mycobacterium lepromatosis may develop leprosy. During the course of the disease, reaction phenomena typical of leprosy often occur, known as type 1 (T1R) and type 2 (T2R). These phenomena aggravate the disease and can cause significant and permanent sequelae. Little is known about the pathophysiological mechanisms of leprosy and its reaction phenomena. In addition, factors inherent to the bacilli and its interaction with the human host, such as energy resources and escape mechanisms, are slowly being revealed. New studies are important to elucidate the pathophysiology of leprosy and, above all, to bring new approaches to the prevention and treatment of leprosy and leprosy reactions. We encourage the submission of clinical, translational, and basic research on leprosy. Some of its focal points include, but are not limited to, the following:

  1. Serum or tissue markers that may be related to the diagnosis of the disease and reactional episodes.
  2. Therapeutic approaches with commercially known drugs or new drug targets.
  3. Clinical studies evaluating the risks of triggering reactional phenomena.
  4. Metabolomic, transcriptomic, or proteomic profiles that correlate with the leprosy clinical forms and reactional phenomena.

Reviews, original research, and communications will be welcome.

Dr. Cleverson Teixeira Soares
Dr. Patrícia Sammarco Rosa
Dr. Bruno de Carvalho Dornelas
Guest Editors

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Keywords

  • Mycobacterium
  • leprosy
  • therapeutic approaches
  • clinical studies

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Published Papers (1 paper)

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Research

15 pages, 2002 KB  
Article
Tissue Expression of NGF in Skin Lesions of HIV-Coinfected and Non-Coinfected Leprosy Patients and Its Relationship with Leprosy Neural Damage
by Marília Brasil Xavier, Lucas dos Santos Fontes, Mariana Garcia Borges do Nascimento, Simone Rodrigues dos Passos, Débora Pinheiro Xavier, Larissa dos Santos Alcantara, Elza Baía de Brito, Cláudia Maria de Castro Gomes and Carlos Eduardo Pereira Corbett
Microorganisms 2025, 13(10), 2271; https://doi.org/10.3390/microorganisms13102271 - 27 Sep 2025
Viewed by 569
Abstract
Leprosy remains a significant public health issue, particularly due to its neuropathic consequences, which affect sensory, motor, and autonomic functions, leading to severe disabilities. HIV/AIDS, another major public health concern, overlaps geographically with leprosy and is also associated with peripheral neuropathies, complicating the [...] Read more.
Leprosy remains a significant public health issue, particularly due to its neuropathic consequences, which affect sensory, motor, and autonomic functions, leading to severe disabilities. HIV/AIDS, another major public health concern, overlaps geographically with leprosy and is also associated with peripheral neuropathies, complicating the management of co-infected patients. Understanding how Nerve Growth Factor (NGF) is regulated in leprosy and HIV-leprosy co-infection may contribute to immunomodulatory treatments and neuroimmune response control. A cross-sectional study evaluated NGF tissue expression using immunohistochemistry in 47 HIV/leprosy co-infected patients and 61 leprosy-only patients. The co-infected group had a higher incidence of neuritis (40.4%) and a prevalence of exclusively reversal reactions. However, the occurrence of neuritis was not associated with higher expression of NGF in the tissue. Leprosy reactions were more prevalent in non-co-infected patients with multibacillary forms (50%). Multibacillary forms in both groups of patients showed higher cellular expression of NGF, with a greater tendency for higher NGF expression in non-co-infected multibacillary patients (p = 0.0021), suggesting impairment in the immune response involved in the tissue expression of neurotrophins in the co-infected group. Overall, co-infection with HIV did not influence the increase in NGF in the lesions of leprosy patients compared with patients with leprosy alone. Full article
(This article belongs to the Special Issue Mycobacterium leprae, Mycobacterium lepromatosis and Leprosy Studies)
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