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Microorganisms, Volume 11, Issue 12

December 2023 - 187 articles

Cover Story: Cutaneous leishmaniasis (CL) is the most common clinical presentation of leishmaniasis, a Neglected Tropical Disease (NTD). While other presentations of leishmaniasis can be fatal, CL is mostly non-lethal and despite its prevalence not a priority for drug treatment. Yet, CL can be disfiguring and cause prolonged suffering in afflicted individuals. Several drugs are currently used to treat leishmaniasis, although they often have harsh side effects and long treatment regimens, and drug resistance is emerging across the globe. In search of novel drug therapies, researchers have been using biochemical and computational techniques for early-stage drug discovery efforts. This review focuses on the substantial yet fragmented progress in drug discovery for CL and highlights the common challenges for researchers. View this paper
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Articles (187)

  • Review
  • Open Access
11 Citations
7,518 Views
25 Pages

Medically Significant Vector-Borne Viral Diseases in Iran

  • Sarah-Jo Paquette,
  • Ayo Yila Simon,
  • Ara XIII,
  • Gary P. Kobinger and
  • Nariman Shahhosseini

Vector-borne viral diseases (VBVDs) continue to pose a considerable public health risk to animals and humans globally. Vectors have integral roles in autochthonous circulation and dissemination of VBVDs worldwide. The interplay of agricultural activi...

  • Review
  • Open Access
6 Citations
4,948 Views
31 Pages

Neisseria meningitidis is commensal of the human pharynx and occasionally invades the host, causing the life-threatening illness invasive meningococcal disease. The meningococcus is a highly diverse and adaptable organism thanks to natural competence...

  • Review
  • Open Access
4 Citations
11,082 Views
25 Pages

Oral Antibiotics for Bacteremia and Infective Endocarditis: Current Evidence and Future Perspectives

  • Gerasimos Eleftheriotis,
  • Markos Marangos,
  • Maria Lagadinou,
  • Sanjay Bhagani and
  • Stelios F. Assimakopoulos

Bacteremia and endocarditis are two clinical syndromes that, for decades, were managed exclusively with parenteral antimicrobials, irrespective of a given patient’s clinical condition, causative pathogen, or its antibiotic susceptibility profil...

  • Article
  • Open Access
4 Citations
1,626 Views
14 Pages

This study investigated the effects of single Fenton and Fenton and UV combined processes on the cracking degree of anaerobic sludge under the same conditions. The optimal experimental conditions were obtained by repeated determination of Fe2+ dosage...

  • Communication
  • Open Access
2 Citations
2,154 Views
11 Pages

Soil Bacterial Diversity Responds to Long-Term Establishment of Perennial Legumes in Warm-Season Grassland at Two Soil Depths

  • Adesuwa Sylvia Erhunmwunse,
  • Victor Alonso Guerra,
  • Jung-Chen Liu,
  • Cheryl L. Mackowiak,
  • Ann Rachel Soffes Blount,
  • José Carlos Batista Dubeux and
  • Hui-Ling Liao

The introduction of rhizoma peanut (RP Arachis glabrata Benth) into bahiagrass (Paspalum notatum Flüggé) may require time to develop stable plant–soil microbe interactions as the microbial legacy of the previous plant comm...

  • Article
  • Open Access
7 Citations
2,569 Views
15 Pages

Cold seeps are highly productive chemosynthetic ecosystems in the deep-sea environment. Although microbial communities affected by methane seepage have been extensively studied in sediments and seawater, there is a lack of investigation of prokaryoti...

  • Article
  • Open Access
2 Citations
2,514 Views
11 Pages

Tigecycline Sensitivity Reduction in Escherichia coli Due to Widely Distributed tet(A) Variants

  • Shan Zhang,
  • Mingquan Cui,
  • Dejun Liu,
  • Bo Fu,
  • Tingxuan Shi,
  • Yang Wang,
  • Chengtao Sun and
  • Congming Wu

Despite scattered studies that have reported mutations in the tet(A) gene potentially linked to tigecycline resistance in clinical pathogens, the detailed function and epidemiology of these tet(A) variants remains limited. In this study, we analyzed...

  • Systematic Review
  • Open Access
11 Citations
2,835 Views
18 Pages

The physiopathology of liver diseases is complex and can be caused by various factors. Bifidobacterium is a bacterial genus commonly found in the human gut microbiome and has been shown to influence the development of different stages of liver diseas...

  • Article
  • Open Access
2 Citations
2,611 Views
19 Pages

Apart from being preventable and treatable, tuberculosis is the deadliest bacterial disease afflicting humankind owing to its ability to evade host defence responses, many of which are controlled by epigenetic mechanisms. Here, we report the temporal...

  • Article
  • Open Access
1 Citations
2,354 Views
15 Pages

Development and Validation of a Highly Sensitive Multiplex Immunoassay for SARS-CoV-2 Humoral Response Monitorization: A Study of the Antibody Response in COVID-19 Patients with Different Clinical Profiles during the First and Second Waves in Cadiz, Spain

  • Lucia Olvera-Collantes,
  • Noelia Moares,
  • Ricardo Fernandez-Cisnal,
  • Juan P. Muñoz-Miranda,
  • Pablo Gonzalez-Garcia,
  • Antonio Gabucio,
  • Carolina Freyre-Carrillo,
  • Juan de Dios Jordan-Chaves,
  • Teresa Trujillo-Soto and
  • Maria P. Rodriguez-Martinez
  • + 5 authors

There is still a long way ahead regarding the COVID-19 pandemic, since emerging waves remain a daunting challenge to the healthcare system. For this reason, the development of new preventive tools and therapeutic strategies to deal with the disease h...

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Microorganisms - ISSN 2076-2607