You are currently viewing a new version of our website. To view the old version click .

Life, Volume 10, Issue 5

May 2020 - 26 articles

Cover Story: Human articular chondrocytes (HACs) synthetize the extracellular matrix (ECM) that confer cartilage its biomechanical properties. HACs failure to produce a balanced ECM leads to osteoarthritis and inflammation worsen the disease. We have shown that miRNA miR-145 silences transcription factor Sox9 resulting in lower and higher levels, respectively, of the main ECM component Col2a1 and the catabolic protease MMP13. Here, by immunoprecipitating the miRNA-induced silencing complex (RISC) in HACs overexpressing miR-145, we identify more than 50 miR-145 new direct targets. One of these targets, DUSP6, contributes to MMP13 repression. Overexpression of miR-145 results in altered expression of hundreds of genes involved in ECM remodelling and immunity and inflammation. Thus, we propose miR-145 inhibition as a potential approach for cartilage repair. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (26)

  • Article
  • Open Access
14 Citations
3,861 Views
13 Pages

Health-Related Quality of Life and Frailty in Chronic Liver Diseases

  • Hiroki Nishikawa,
  • Kazunori Yoh,
  • Hirayuki Enomoto,
  • Yoshinori Iwata,
  • Yoshiyuki Sakai,
  • Kyohei Kishino,
  • Yoshihiro Shimono,
  • Naoto Ikeda,
  • Tomoyuki Takashima and
  • Nobuhiro Aizawa
  • + 7 authors

24 May 2020

We sought to examine the relationship between frailty and health-related quality of life as evaluated using the 36-item Short-Form Health Survey (SF-36) questionnaire in Japanese chronic liver disease (CLD) patients (n = 341, 122 liver cirrhosis case...

  • Article
  • Open Access
7 Citations
3,471 Views
14 Pages

Trace Elements in Home-Processed Food Obtained from Unconventional Animals

  • Emilio Carpenè,
  • Giulia Andreani,
  • Enea Ferlizza,
  • Simonetta Menotta,
  • Giorgio Fedrizzi and
  • Gloria Isani

23 May 2020

Wild animals have been used as food since ancient times and, currently, the consumption of unconventional animals is increasing worldwide. The process of cooking meat using traditional recipes includes a variety of ingredients, which can influence th...

  • Article
  • Open Access
11 Citations
13,440 Views
9 Pages

21 May 2020

Background: Intermittent fasting (IF) combined with exercise has been suggested to enhance weight loss. However, both procedures might negatively influence acid–base status. The aim of this study was to determine the combined effects of IF, exe...

  • Article
  • Open Access
13 Citations
3,994 Views
14 Pages

Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolemia: A Propensity Score Analysis

  • Agnieszka Mickiewicz,
  • Marta Futema,
  • Agnieszka Ćwiklinska,
  • Agnieszka Kuchta,
  • Maciej Jankowski,
  • Mariusz Kaszubowski,
  • Magdalena Chmara,
  • Bartosz Wasąg,
  • Marcin Fijałkowski and
  • Miłosz Jaguszewski
  • + 2 authors

20 May 2020

Background: The monogenic defect in familial hypercholesterolemia (FH) is detected in ∼40% of cases. The majority of mutation-negative patients have a polygenic cause of high LDL-cholesterol (LDL-C). We sought to investigate whether the underlyin...

  • Review
  • Open Access
46 Citations
14,793 Views
26 Pages

Recent Advances in the Photoautotrophic Metabolism of Cyanobacteria: Biotechnological Implications

  • Théo Veaudor,
  • Victoire Blanc-Garin,
  • Célia Chenebault,
  • Encarnación Diaz-Santos,
  • Jean-François Sassi,
  • Corinne Cassier-Chauvat and
  • Franck Chauvat

19 May 2020

Cyanobacteria constitute the only phylum of oxygen-evolving photosynthetic prokaryotes that shaped the oxygenic atmosphere of our planet. Over time, cyanobacteria have evolved as a widely diverse group of organisms that have colonized most aquatic an...

  • Article
  • Open Access
8 Citations
4,723 Views
13 Pages

Subtypes of Depression: Latent Class Analysis in Spanish Old People with Depressive Symptoms

  • Sergio Pérez-Belmonte,
  • Laura Galiana,
  • Patricia Sancho,
  • Amparo Oliver and
  • José M. Tomás

18 May 2020

Major depressive disorder (MDD) is one of the most disabling disorders and the one that most contributes to disability. When it occurs in older people, it is an additional burden to their potential physical and cognitive deficiencies, making MDD an i...

  • Article
  • Open Access
15 Citations
19,123 Views
12 Pages

The Therapeutic Effectiveness of Full Spectrum Hemp Oil Using a Chronic Neuropathic Pain Model

  • Jacob M. Vigil,
  • Marena A. Montera,
  • Nathan S. Pentkowski,
  • Jegason P. Diviant,
  • Joaquin Orozco,
  • Anthony L. Ortiz,
  • Lawrence J. Rael and
  • Karin N. Westlund

18 May 2020

Background: Few models exist that can control for placebo and expectancy effects commonly observed in clinical trials measuring ‘Cannabis’ pharmacodynamics. We used the Foramen Rotundum Inflammatory Constriction Trigeminal Infraorbital Ne...

  • Article
  • Open Access
10 Citations
5,675 Views
29 Pages

Identification of Differentially Expressed Gene Transcripts in Porcine Endometrium during Early Stages of Pregnancy

  • Mariusz Pierzchała,
  • Dorota Pierzchała,
  • Magdalena Ogłuszka,
  • Ewa Poławska,
  • Tadeusz Blicharski,
  • Agnieszka Roszczyk,
  • Agata Nawrocka,
  • Pawel Urbański,
  • Kamila Stepanow and
  • Aleksandra Ciepłoch
  • + 13 authors

16 May 2020

During the early stages of pregnancy, the uterine endometrium undergoes dramatic morphologic and functional changes accompanied with dynamic variation in gene expression. Pregnancy-stage specific differentially expressed gene (DEG)-transcript-probes...

  • Article
  • Open Access
5 Citations
3,896 Views
22 Pages

Biosignatures Associated with Freshwater Microbialites

  • Richard Allen White,
  • Sarah A. Soles,
  • Allyson L. Brady,
  • Gordon Southam,
  • Darlene S.S. Lim and
  • Greg F. Slater

15 May 2020

Freshwater microbialites (i.e., lithifying microbial mats) are quite rare in northern latitudes of the North American continent, with two lakes (Pavilion and Kelly Lakes) of southeastern BC containing a morphological variety of such structures. We in...

of 3

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Life - ISSN 2075-1729