Table of Contents
Life, Volume 10, Issue 6 (June 2020) – 22 articles
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Cover Story (view full-size image) Gab2 is a scaffold protein with a crucial role in colocalizing signaling proteins and is involved [...] Read more. Gab2 is a scaffold protein with a crucial role in colocalizing signaling proteins and is involved in the regulation of several important molecular pathways. SHP2 is a protein phosphatase that binds specific consensus sequences on Gab2 through its two SH2 domains. A complete mutational analysis of the kinetics of binding between the N-SH2 domain of SHP2 and a peptide mimicking a specific region of Gab2 allowed us to unveil structural features of the transition state of the N-SH2 domain binding to Gab2, revealing remarkable cooperativity of the binding reaction. Comparison with kinetic data from another SH2 domain suggests the presence of underlying general features characterizing the binding process of SH2 domains. View this paper