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Life, Volume 10, Issue 6

June 2020 - 22 articles

Cover Story: Gab2 is a scaffold protein with a crucial role in colocalizing signaling proteins and is involved in the regulation of several important molecular pathways. SHP2 is a protein phosphatase that binds specific consensus sequences on Gab2 through its two SH2 domains. A complete mutational analysis of the kinetics of binding between the N-SH2 domain of SHP2 and a peptide mimicking a specific region of Gab2 allowed us to unveil structural features of the transition state of the N-SH2 domain binding to Gab2, revealing remarkable cooperativity of the binding reaction. Comparison with kinetic data from another SH2 domain suggests the presence of underlying general features characterizing the binding process of SH2 domains. View this paper
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Articles (22)

  • Article
  • Open Access
3 Citations
3,856 Views
9 Pages

Rat Animal Model of Pectus Excavatum

  • Vlad-Laurentiu David,
  • Bogdan Ciornei,
  • Florin-George Horhat,
  • Elena Amaricai,
  • Ioana-Delia Horhat,
  • Teodora Hoinoiu and
  • Eugen-Sorin Boia

26 June 2020

Background: pectus excavatum (PE) is the most common congenital deformity of the thoracic wall. Lately, significant achievements have been made in finding new, less invasive treatment methods for PE. However, most of the experimental work was carried...

  • Article
  • Open Access
9 Citations
4,438 Views
16 Pages

Development of a Simple Kinetic Mathematical Model of Aggregation of Particles or Clustering of Receptors

  • Andrei K. Garzon Dasgupta,
  • Alexey A. Martyanov,
  • Aleksandra A. Filkova,
  • Mikhail A. Panteleev and
  • Anastasia N. Sveshnikova

26 June 2020

The process of clustering of plasma membrane receptors in response to their agonist is the first step in signal transduction. The rate of the clustering process and the size of the clusters determine further cell responses. Here we aim to demonstrate...

  • Article
  • Open Access
8 Citations
3,635 Views
12 Pages

26 June 2020

The membrane binding by α-synuclein (αS), a presynaptic protein whose aggregation is strongly linked with Parkinson’s disease, influences its biological behavior under functional and pathological conditions. This interaction require...

  • Review
  • Open Access
32 Citations
7,544 Views
42 Pages

The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery—A Systematic Review and Meta-Analysis

  • Ewa Trams,
  • Krzysztof Kulinski,
  • Katarzyna Kozar-Kaminska,
  • Stanislaw Pomianowski and
  • Rafal Kaminski

25 June 2020

In recent years, the interest in biological treatment of knee lesions has increased, especially the application of platelet-rich plasma is of particular note. The number of articles evaluating platelet-rich plasma (PRP) efficacy in the recovery of kn...

  • Review
  • Open Access
19 Citations
4,650 Views
15 Pages

25 June 2020

Transposable element (TE) has the ability to insert into certain parts of the genome, and due to this event, it is possible for TEs to generate new factors and one of these factors are microRNAs (miRNA). miRNAs are non-coding RNAs made up of 19 to 24...

  • Article
  • Open Access
15 Citations
4,391 Views
21 Pages

Arsenolipids in Cultured Picocystis Strain ML and Their Occurrence in Biota and Sediment from Mono Lake, California

  • Ronald A. Glabonjat,
  • Jodi S. Blum,
  • Laurence G. Miller,
  • Samuel M. Webb,
  • John F. Stolz,
  • Kevin A. Francesconi and
  • Ronald S. Oremland

24 June 2020

Primary production in Mono Lake, a hypersaline soda lake rich in dissolved inorganic arsenic, is dominated by Picocystis strain ML. We set out to determine if this photoautotrophic picoplankter could metabolize inorganic arsenic and in doing so form...

  • Article
  • Open Access
11 Citations
4,470 Views
16 Pages

Antimicrobial Activity of Microorganisms Isolated from Ant Nests of Lasius niger

  • Tatiana A. Efimenko,
  • Alla A. Glukhova,
  • Mariia V. Demiankova,
  • Yuliya V. Boykova,
  • Natalia D. Malkina,
  • Irina G. Sumarukova,
  • Byazilya F. Vasilieva,
  • Eugene A. Rogozhin,
  • Igor A. Ivanov and
  • Vladislav A. Krassilnikov
  • + 1 author

22 June 2020

In this study, the microbial communities of two nests of black garden ants (Lasius niger) in the hollows of stem branches of old apple trees were found to have similar species compositions: each community contained representatives of three species fr...

  • Communication
  • Open Access
5 Citations
3,487 Views
7 Pages

Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Can Prevent Severe Postoperative Pain: A Retrospective Chart Review

  • Rikuhei Tsuchida,
  • Masahiko Sumitani,
  • Hiroaki Abe,
  • Masae Ando,
  • Kosuke Saita,
  • Kohshi Hattori,
  • Kazuhito Mietani,
  • Reo Inoue and
  • Kanji Uchida

22 June 2020

The purinergic P2Y12 receptor regulates microglial activation, resulting in persistence and aggravation of pain in neuropathic and nociceptive pain models. We conducted a retrospective chart review to explore the analgesic potency of the P2Y12 recept...

  • Article
  • Open Access
10 Citations
4,881 Views
14 Pages

21 June 2020

Our previous study showed a satisfactory reproductive outcome resulting from the patient-friendly ovarian stimulation protocol using long-acting follicle stimulation hormone (FSH) plus oral medroxyprogesterone acetate (MPA). The present retrospective...

  • Review
  • Open Access
15 Citations
6,316 Views
22 Pages

Mass Spectrometry: A Rosetta Stone to Learn How Fungi Interact and Talk

  • Erika Calla-Quispe,
  • Hammerly Lino Fuentes-Rivera,
  • Pablo Ramírez,
  • Carlos Martel and
  • Alfredo J. Ibañez

20 June 2020

Fungi are a highly diverse group of heterotrophic organisms that play an important role in diverse ecological interactions, many of which are chemically mediated. Fungi have a very versatile metabolism, which allows them to synthesize a large number...

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Life - ISSN 2075-1729