Next Article in Journal
Targeting the C-Terminal Domain Small Phosphatase 1
Previous Article in Journal
DnaK3 Is Involved in Biogenesis and/or Maintenance of Thylakoid Membrane Protein Complexes in the Cyanobacterium Synechocystis sp. PCC 6803
Previous Article in Special Issue
A Strategy for Combinatorial Cavity Design in De Novo Proteins
Open AccessReview

Synthetic Biology Approaches to Engineer Saccharomyces cerevisiae towards the Industrial Production of Valuable Polyphenolic Compounds

Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal
*
Author to whom correspondence should be addressed.
Life 2020, 10(5), 56; https://doi.org/10.3390/life10050056
Received: 1 April 2020 / Revised: 22 April 2020 / Accepted: 30 April 2020 / Published: 2 May 2020
Polyphenols are plant secondary metabolites with diverse biological and potential therapeutic activities such as antioxidant, anti-inflammatory and anticancer, among others. However, their extraction from the native plants is not enough to satisfy the increasing demand for this type of compounds. The development of microbial cell factories to effectively produce polyphenols may represent the most attractive solution to overcome this limitation and produce high amounts of these bioactive molecules. With the advances in the synthetic biology field, the development of efficient microbial cell factories has become easier, largely due to the development of the molecular biology techniques and by the identification of novel isoenzymes in plants or simpler organisms to construct the heterologous pathways. Furthermore, efforts have been made to make the process more profitable through improvements in the host chassis. In this review, advances in the production of polyphenols by genetically engineered Saccharomyces cerevisiae as well as by synthetic biology and metabolic engineering approaches to improve the production of these compounds at industrial settings are discussed. View Full-Text
Keywords: polyphenols biosynthesis; synthetic biology; Saccharomyces cerevisiae; metabolic engineering; heterologous production polyphenols biosynthesis; synthetic biology; Saccharomyces cerevisiae; metabolic engineering; heterologous production
Show Figures

Figure 1

MDPI and ACS Style

Rainha, J.; Gomes, D.; Rodrigues, L.R.; Rodrigues, J.L. Synthetic Biology Approaches to Engineer Saccharomyces cerevisiae towards the Industrial Production of Valuable Polyphenolic Compounds. Life 2020, 10, 56.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop