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Toxins, Volume 11, Issue 4

April 2019 - 55 articles

Cover Story: Following ingestion of Shiga toxin-producing bacteria, the organisms attach or invade the intestinal epithelium and secrete toxins. Shiga toxins are translocated across the intestinal mucosa and enter the bloodstream. Immune cells, including neutrophils and monocytes, may act as toxin “carrier cells”. In target organs such as the kidneys and brain, the toxins are transferred to endothelial cells, expressing high affinity glycolipid toxin receptors, resulting in systemic disease, such as diarrhea-associated hemolytic uremic syndrome and CNS abnormalities. The innate immune response may be activated in each step of toxin transport to contribute to pathology. View this paper.
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Articles (55)

  • Article
  • Open Access
11 Citations
5,475 Views
11 Pages

Isolation and Characterization of Insecticidal Toxins from the Venom of the North African Scorpion, Buthacus leptochelys

  • Yusuke Yoshimoto,
  • Masahiro Miyashita,
  • Mohammed Abdel-Wahab,
  • Moustafa Sarhan,
  • Yoshiaki Nakagawa and
  • Hisashi Miyagawa

25 April 2019

Various bioactive peptides have been identified in scorpion venom, but there are many scorpion species whose venom has not been investigated. In this study, we characterized venom components of the North African scorpion, Buthacus leptochelys, by mas...

  • Article
  • Open Access
17 Citations
5,011 Views
11 Pages

25 April 2019

Ovarian cancer ranks amongst the deadliest cancers in the gynaecological category of cancers. This research work aims to evaluate in vitro anti-ovarian cancer activities and identify phytochemical constituents of a rarely explored plant species&mdash...

  • Article
  • Open Access
27 Citations
4,674 Views
15 Pages

Uremic Toxin Concentrations are Related to Residual Kidney Function in the Pediatric Hemodialysis Population

  • Evelien Snauwaert,
  • Els Holvoet,
  • Wim Van Biesen,
  • Ann Raes,
  • Griet Glorieux,
  • Johan Vande Walle,
  • Sanne Roels,
  • Raymond Vanholder,
  • Varvara Askiti and
  • Karolis Azukaitis
  • + 19 authors

24 April 2019

Protein-bound uremic toxins (PBUTs) play a role in the multisystem disease that children on hemodialysis (HD) are facing, but little is known about their levels and protein binding (%PB). In this study, we evaluated the levels and %PB of six PBUTs cr...

  • Article
  • Open Access
13 Citations
4,832 Views
11 Pages

Clostridium perfringens Delta-Toxin Damages the Mouse Small Intestine

  • Soshi Seike,
  • Masaya Takehara,
  • Keiko Kobayashi and
  • Masahiro Nagahama

22 April 2019

Clostridium perfringens strains B and C cause fatal intestinal diseases in animals. The secreted pore-forming toxin delta-toxin is one of the virulence factors of the strains, but the mechanism of intestinal pathogenesis is unclear. Here, we investig...

  • Article
  • Open Access
35 Citations
6,440 Views
15 Pages

Structural Insights to the Heterotetrameric Interaction between the Vibrio parahaemolyticus PirAvp and PirBvp Toxins and Activation of the Cry-Like Pore-Forming Domain

  • Shin-Jen Lin,
  • Yi-Fan Chen,
  • Kai-Cheng Hsu,
  • Yun-Ling Chen,
  • Tzu-Ping Ko,
  • Chu-Fang Lo,
  • Han-Ching Wang and
  • Hao-Ching Wang

22 April 2019

Acute hepatopancreatic necrosis disease (AHPND) is a newly emergent penaeid shrimp disease which can cause 70–100% mortality in Penaeus vannamei and Penaeus monodon, and has resulted in enormous economic losses since its appearance. AHPND is ca...

  • Article
  • Open Access
26 Citations
9,749 Views
9 Pages

Antiparasitic Properties of Cantharidin and the Blister Beetle Berberomeloe majalis (Coleoptera: Meloidae)

  • Douglas W. Whitman,
  • Maria Fe Andrés,
  • Rafael A. Martínez-Díaz,
  • Alexandra Ibáñez-Escribano,
  • A. Sonia Olmeda and
  • Azucena González-Coloma

22 April 2019

Cantharidin (CTD) is a toxic monoterpene produced by blister beetles (Fam. Meloidae) as a chemical defense against predators. Although CTD is highly poisonous to many predator species, some have evolved the ability to feed on poisonous Meloidae, or o...

  • Article
  • Open Access
10 Citations
4,980 Views
14 Pages

CesH Represses Cereulide Synthesis as an Alpha/Beta Fold Hydrolase in Bacillus cereus

  • Shen Tian,
  • Hairong Xiong,
  • Peiling Geng,
  • Zhiming Yuan and
  • Xiaomin Hu

21 April 2019

Cereulide is notorious as a heat-stable emetic toxin produced by Bacillus cereus and glucose is supposed to be an ingredient supporting its formation. This study showed that glucose addition benefited on cell growth and the early transcription of gen...

  • Article
  • Open Access
38 Citations
7,979 Views
18 Pages

19 April 2019

Eggplant contains glycoalkaloids (GAs), a class of nitrogen-containing secondary metabolites of great structural variety that may have both adverse and beneficial biological effects. In this study, we performed a complete survey of GAs and their malo...

  • Article
  • Open Access
19 Citations
4,623 Views
14 Pages

Dehydrocrenatidine Inhibits Voltage-Gated Sodium Channels and Ameliorates Mechanic Allodia in a Rat Model of Neuropathic Pain

  • Fang Zhao,
  • Qinglian Tang,
  • Jian Xu,
  • Shuangyan Wang,
  • Shaoheng Li,
  • Xiaohan Zou and
  • Zhengyu Cao

18 April 2019

Picrasma quassioides (D. Don) Benn, a medical plant, is used in clinic to treat inflammation, pain, sore throat, and eczema. The alkaloids are the main active components in P. quassioides. In this study, we examined the analgesic effect of dehydrocre...

  • Article
  • Open Access
2 Citations
3,721 Views
20 Pages

Evaluation of Cytotoxicity and Mould Contamination of Selected Plants from Meadows Covered by the Agri-Environmental Program

  • Magdalena Twarużek,
  • Romuald Dembek,
  • Dariusz Pańka,
  • Ewelina Soszczyńska,
  • Ewa Zastempowska and
  • Jan Grajewski

17 April 2019

The aim of the study was the evaluation of selected species of meadow plants obtained from the first cut from the area covered by the agri-environmental program ‘Natura 2000’ in terms of the presence of cytotoxic compounds detected by the...

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Toxins - ISSN 2072-6651Creative Common CC BY license