Table of Contents
Toxins, Volume 11, Issue 4 (April 2019)
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Cover Story (view full-size image) Following ingestion of Shiga toxin-producing bacteria, the organisms attach or invade the [...] Read more. Following ingestion of Shiga toxin-producing bacteria, the organisms attach or invade the intestinal epithelium and secrete toxins. Shiga toxins are translocated across the intestinal mucosa and enter the bloodstream. Immune cells, including neutrophils and monocytes, may act as toxin “carrier cells”. In target organs such as the kidneys and brain, the toxins are transferred to endothelial cells, expressing high affinity glycolipid toxin receptors, resulting in systemic disease, such as diarrhea-associated hemolytic uremic syndrome and CNS abnormalities. The innate immune response may be activated in each step of toxin transport to contribute to pathology. View this paper.