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Toxins 2019, 11(4), 217; https://doi.org/10.3390/toxins11040217

Assessment of Toxic Effects of Ochratoxin A in Human Embryonic Stem Cells

1
Stem Cells Therapies in Neurodegenerative Diseases Lab, Research Center “Principe Felipe”, Valencia 46012, Spain
2
Department of Microbiology and Ecology, University of Valencia, Valencia 46100, Spain
3
Department of Biomedical Sciences, School of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia 46115, Spain
4
Department of Biomedical Sciences, School of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, Elche, Alicante 03204, Spain
5
Department of Pharmacy, School of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities. Elche, Alicante 03204, Spain
*
Authors to whom correspondence should be addressed.
Received: 21 February 2019 / Revised: 2 April 2019 / Accepted: 4 April 2019 / Published: 10 April 2019
(This article belongs to the Special Issue Toxicological Effects of Mycotoxin on Target Cells)
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Abstract

Ochratoxin A (OTA) is a mycotoxin produced by different Aspergillus and Penicillium species, and it is considered a common contaminant in food and animal feed worldwide. On the other hand, human embryonic stem cells (hESCs) have been suggested as a valuable model for evaluating drug embryotoxicity. In this study, we have evaluated potentially toxic effects of OTA in hESCs. By using in vitro culture techniques, specific cellular markers, and molecular biology procedures, we found that OTA produces mild cytotoxic effects in hESCs by inhibiting cell attachment, survival, and proliferation in a dose-dependent manner. Thus, we suggest that hESCs provide a valuable human and cellular model for toxicological studies regarding preimplantation stage of human fetal development. View Full-Text
Keywords: Ochratoxin A (OTA); human Stem Cells; mycotoxins; cells; cytotoxicity; cell culture Ochratoxin A (OTA); human Stem Cells; mycotoxins; cells; cytotoxicity; cell culture
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Erceg, S.; Mateo, E.M.; Zipancic, I.; Rodríguez Jiménez, F.J.; Pérez Aragó, M.A.; Jiménez, M.; Soria, J.M.; Garcia-Esparza, M.Á. Assessment of Toxic Effects of Ochratoxin A in Human Embryonic Stem Cells. Toxins 2019, 11, 217.

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