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Neurology International, Volume 16, Issue 5

2024 October - 22 articles

Cover Story: Alzheimer’s disease (AD) is an age-related degenerative brain disorder characterized by a progressive decline in cognitive function and memory. Current AD treatments are minimally effective and often come with significant side effects. Rutin hydrate (RH), a well-known flavonoid, shows promising potential and health benefits due to its strong anti-inflammatory, anti-hypertensive, and potent antioxidant properties. This study highlights the molecular and cellular mechanisms through which RH exerts its neuroprotective effects in the prevention and treatment of learning and memory deficit disorders. RH could potentially be used as a therapeutic strategy for restoring learning and memory function and preventing the progression of AD. View this paper
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Articles (22)

  • Article
  • Open Access
3 Citations
5,179 Views
11 Pages

Redefining Infarction Size for Small-Vessel Occlusion in Acute Ischemic Stroke: A Retrospective Case–Control Study

  • Yen-Chu Huang,
  • Hsu-Huei Weng,
  • Leng-Chieh Lin,
  • Jiann-Der Lee,
  • Jen-Tsung Yang,
  • Yuan-Hsiung Tsai and
  • Chao-Hui Chen

21 October 2024

Background/Objectives: Small-vessel occlusion, previously referred to as lacunar infarcts, accounts for approximately one-third of all ischemic strokes, using an axial diameter of less than 20 mm on diffusion-weighted imaging. However, this threshold...

(This article belongs to the Special Issue Treatment Strategy and Mechanism of Acute Ischemic Stroke)
  • Hypothesis
  • Open Access
3 Citations
6,078 Views
6 Pages

17 October 2024

Embryologically, the left brachiocephalic vein (LBV) originates as an anastomotic channel between the right and left anterior cardinal veins. This positions the LBV between the manubrium sterni anteriorly and the innominate artery posteriorly. This p...

  • Article
  • Open Access
1 Citations
10,823 Views
15 Pages

A Retrospective Study of Lateral Antebrachial Cutaneous Nerve Neuropathy: Electrodiagnostic Findings and Etiologies in 49 Cases

  • Vasudeva G. Iyer,
  • Lisa B. E. Shields,
  • Michael W. Daniels,
  • Yi Ping Zhang and
  • Christopher B. Shields

10 October 2024

Background: The lateral antebrachial cutaneous nerve (LACN) is the terminal sensory branch of the musculocutaneous nerve and is rarely entrapped or injured. This study describes the electrodiagnostic (EDX) findings and etiologies of LACN neuropathy....

  • Case Report
  • Open Access
1 Citations
3,483 Views
11 Pages

Adult Case of Pontocerebellar Hypoplasia without the Claustrum

  • Koji Hayashi,
  • Shiho Mitsuhashi,
  • Ei Kawahara,
  • Asuka Suzuki,
  • Yuka Nakaya,
  • Mamiko Sato and
  • Yasutaka Kobayashi

7 October 2024

We describe the case of a 63-year-old man with pontocerebellar hypoplasia without the claustrum (CL). The patient had a history of cerebral palsy, intelligent disability, cerebellar atrophy, and seizures since birth. At age 61, brain computed tomogra...

(This article belongs to the Collection Advances in Neurodegenerative Diseases)
  • Article
  • Open Access
7 Citations
4,832 Views
10 Pages

30 September 2024

Background: Working memory (WM) involves temporarily storing and manipulating information. Research on the impact of aging on WM has shown inconsistent results regarding the decline in visual and verbal WM, with a lack of studies on tactile WM. This...

  • Case Report
  • Open Access
5 Citations
5,908 Views
10 Pages

Froin’s Syndrome: A Comprehensive Review of the Literature and the Addition of Two New Cases

  • Lucas Jacobs,
  • Bertil Delsaut,
  • Marta Lamartine S. Monteiro,
  • Audrey Cambier,
  • Ibrahim Alcan,
  • Evelyne Maillart and
  • Maxime Taghavi

29 September 2024

Background. Froin’s syndrome (FS) is a rare entity with uncertain prevalence and prognosis, defined by a pathognomonic triad: cerebrospinal fluid (CSF) xanthochromia, elevated protein levels in the CSF, and hypercoagulated CSF, usually obtained...

  • Article
  • Open Access
13 Citations
4,026 Views
18 Pages

Neuroprotective Properties of Rutin Hydrate against Scopolamine-Induced Deficits in BDNF/TrkB/ERK/CREB/Bcl2 Pathways

  • Inturu Sreelatha,
  • Ga-Young Choi,
  • In-Seo Lee,
  • Omkaram Inturu,
  • Hyun-Sook Lee,
  • Yea-Na Park,
  • Cheol-Won Lee,
  • Inkyou Yang,
  • Sungho Maeng and
  • Ji-Ho Park

27 September 2024

Background/Objectives: Alzheimer’s disease (AD) is an age-related degenerative brain disorder characterized by a progressive decline in cognitive function and memory. This study aimed to evaluate whether rutin hydrate (RH) has neuroprotective e...

  • Article
  • Open Access
5 Citations
2,628 Views
8 Pages

Validity and Reliability of the Japanese Version of the Frontal Assessment Battery in Patients with Stroke

  • Katsuya Sakai,
  • Yuichiro Hosoi,
  • Yusuke Harada,
  • Kenji Morikawa and
  • Yuichi Kato

25 September 2024

Background: The Frontal Assessment Battery (FAB), which is used to assess executive function, has been translated into several languages and shown to be valid and reliable. However, the validity and reliability of the Japanese version in patients wit...

  • Article
  • Open Access
3 Citations
2,802 Views
20 Pages

23 September 2024

Background/Objectives: Aging has been extensively studied, with a growing interest in memory impairment by a neurobiological approach. Mitochondrial dysfunction is a hallmark of aging, contributing to the aging phenotype; therefore, mitochondrial int...

  • Review
  • Open Access
34 Citations
18,461 Views
27 Pages

A Systematic Review of Sporadic Creutzfeldt-Jakob Disease: Pathogenesis, Diagnosis, and Therapeutic Attempts

  • Maria Carolina Jurcau,
  • Anamaria Jurcau,
  • Razvan Gabriel Diaconu,
  • Vlad Octavian Hogea and
  • Vharoon Sharma Nunkoo

20 September 2024

Creutzfeldt-Jakob disease is a rare neurodegenerative and invariably fatal disease with a fulminant course once the first clinical symptoms emerge. Its incidence appears to be rising, although the increasing figures may be related to the improved dia...

  • Article
  • Open Access
7 Citations
3,449 Views
13 Pages

Outcome Prediction by Diffusion Tensor Imaging (DTI) in Patients with Traumatic Injuries of the Median Nerve

  • Théa Voser,
  • Manuel Martin,
  • Issiaka Muriset,
  • Michaela Winkler,
  • Jean-Baptiste Ledoux,
  • Yasser Alemán-Gómez and
  • Sébastien Durand

19 September 2024

Background/Objectives: The accurate quantification of peripheral nerve axonal regeneration after injury is critically important. Current strategies are limited to detecting early reinnervation. DTI is an MRI modality permitting the assessment of frac...

  • Case Report
  • Open Access
2,238 Views
12 Pages

15 September 2024

Background: Humeral shaft fractures are relatively common. Complications associated with this type of fracture and its treatment include nonunion and radial nerve palsy. Plate osteosynthesis with autologous bone grafting is considered the gold standa...

  • Brief Report
  • Open Access
2,173 Views
9 Pages

Romanian Translation and Cultural Adaptation of the Seizure Severity Questionnaire

  • Ionut-Horia Cioriceanu,
  • Dan-Alexandru Constantin,
  • Bianca Zamfirescu,
  • Petru Cezar Podasca,
  • Luigi Geo Marceanu and
  • Liliana Rogozea

13 September 2024

The aim of this study was to report the translation into Romanian of the Seizure Severity Questionnaire (SSQ), an instrument for the evaluation of the frequency and severity of epileptic seizures, and the results of applying it to a group of patients...

(This article belongs to the Special Issue Selected Papers from "Brainstorming Research Assembly for Young Neuroscientists (BraYn))
  • Article
  • Open Access
2 Citations
2,196 Views
13 Pages

Cerebrovascular Reactivity Assessed by Breath-Hold Functional MRI in Patients with Neurological Post-COVID-19 Syndrome—A Pilot Study

  • Leonie Zerweck,
  • Uwe Klose,
  • Annerose Mengel,
  • Tobias Hoheisel,
  • Melinda Eikemeier,
  • Vivien Richter,
  • Natalie Sophie Joos,
  • Ulrike Ernemann,
  • Benjamin Bender and
  • Till-Karsten Hauser

9 September 2024

Endothelial dysfunction represents a potential pathomechanism of neurological post-COVID-19 syndrome (PCS). A recent study demonstrated reduced cerebrovascular reactivity (CVR) in patients with PCS. The aim of this pilot study was to prospectively as...

  • Article
  • Open Access
1 Citations
2,228 Views
16 Pages

5 September 2024

Pathologies associated with neural blood disturbance have been reported in patients with chronic nerve compression (CNC) neuropathy. Fluorescein angiography (FAG) and laser Doppler flowmetry (LDF) are effective for real-time peripheral nerve blood fl...

  • Article
  • Open Access
6 Citations
6,320 Views
10 Pages

The Clinical Manifestations, Risk Factors, Etiologies, and Outcomes of Adult Patients with Infectious Meningitis and Encephalitis: Single Center Experience

  • Seraj Makkawi,
  • Shatha Alqurashi,
  • Wejdan Hubayni,
  • Saleha Almahdawi,
  • Sadeem Bahkali,
  • Abeer Alharbi,
  • Osama Khojah,
  • Aisha Halawani and
  • Israa Malli

5 September 2024

(1) Background: Central nervous system (CNS) infections, including meningitis and encephalitis, are serious conditions which are associated with high morbidity and mortality. This study aims to identify the clinical manifestations, etiologies, and ou...

  • Case Report
  • Open Access
2,355 Views
8 Pages

Transient Ipsilateral Hemineglect Following Brain Laser Ablation in Patient with Focal Cortical Dysplasia

  • Georgios Ntolkeras,
  • Fatemeh Mohammadpour Touserkani,
  • Michelle Y. Chiu,
  • Sanjay P. Prabhu,
  • Scellig Stone and
  • Alexander Rotenberg

3 September 2024

Sensory integration is the province of the parietal lobe. The non-dominant hemisphere is responsible for both body sides, while the dominant hemisphere is responsible for the contralateral hemi-body. Furthermore, the posterior cingulate cortex (PCC)...

  • Article
  • Open Access
1 Citations
3,017 Views
13 Pages

31 August 2024

This study investigates the cognitive mechanisms underlying vigilance and pattern recognition using a novel adaptation of Mackworth’s Clock Test. We aimed to quantify the time it takes for temporal patterns detected unconsciously through implic...

  • Review
  • Open Access
4 Citations
6,630 Views
12 Pages

Perspectives on Stem Cell Therapy in Diabetic Neuropathic Pain

  • Tadeu Lima Montagnoli,
  • Aimeé Diogenes Santos,
  • Susumu Zapata Sudo,
  • Fernanda Gubert,
  • Juliana Ferreira Vasques,
  • Rosalia Mendez-Otero,
  • Mauro Paes Leme de Sá and
  • Gisele Zapata-Sudo

30 August 2024

Diabetes mellitus-related morbidity and mortality are primarily caused by long-term complications such as retinopathy, nephropathy, cardiomyopathy, and neuropathy. Diabetic neuropathy (DN) involves the progressive degeneration of axons and nerve fibe...

  • Article
  • Open Access
1 Citations
3,959 Views
15 Pages

Understanding the Changes in Brain Activation When Viewing Products with Differences in Attractiveness

  • Emily L. L. Sin,
  • Clive H. Y. Wong,
  • Bolton K. H. Chau,
  • Matthias Rauterberg,
  • Kin Wai Michael Siu and
  • Yi-Teng Shih

28 August 2024

Product design and attractiveness are pivotal factors that determine people’s positive reactions when viewing a product and may eventually affect their purchasing choices. Comprehending how people assess product design is crucial. Various studi...

  • Article
  • Open Access
4 Citations
2,320 Views
13 Pages

HSPB4/CRYAA Protect Photoreceptors during Retinal Detachment in Part through FAIM2 Regulation

  • Cagri G. Besirli,
  • Madhu Nath,
  • Jingyu Yao,
  • Mercy Pawar,
  • Angela M. Myers,
  • David Zacks and
  • Patrice E. Fort

26 August 2024

Our previous study discussed crystallin family induction in an experimental rat model of retinal detachment. Therefore, we attempted to evaluate the role of α-crystallin in photoreceptor survival in an experimental model of retinal detachment,...

(This article belongs to the Collection Advances in Neurodegenerative Diseases)
  • Article
  • Open Access
7 Citations
2,291 Views
14 Pages

Quality of Life Assessment in Romanian Patients with Spinal Muscular Atrophy Undergoing Nusinersen Treatment

  • Bogdana Cavaloiu,
  • Iulia-Elena Simina,
  • Lazar Chisavu,
  • Crisanda Vilciu,
  • Iuliana-Anamaria Trăilă and
  • Maria Puiu

26 August 2024

Spinal muscular atrophy (SMA), identified over a century ago, is characterized by severe muscle wasting and early mortality. Despite its rarity, the high carrier frequency of the responsible genetic mutations and the variability in its manifestations...

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Neurol. Int. - ISSN 2035-8377