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  • Review
  • Open Access
31 Citations
31,063 Views
16 Pages

Chronic Administration of Melatonin: Physiological and Clinical Considerations

  • Donald Givler,
  • Amy Givler,
  • Patrick M. Luther,
  • Danielle M. Wenger,
  • Shahab Ahmadzadeh,
  • Sahar Shekoohi,
  • Amber N. Edinoff,
  • Bradley K. Dorius,
  • Carlo Jean Baptiste and
  • Elyse M. Cornett
  • + 2 authors

15 March 2023

Background: Exogenous melatonin is commonly used to treat insomnia, other sleep problems, and numerous medical illnesses, including Alzheimer’s disease, autism spectrum disorder, and mild cognitive impairment in adults and children. There is ev...

  • Review
  • Open Access
24 Citations
23,863 Views
54 Pages

Migraine: Advances in the Pathogenesis and Treatment

  • Horia Pleș,
  • Ioan-Alexandru Florian,
  • Teodora-Larisa Timis,
  • Razvan-Adrian Covache-Busuioc,
  • Luca-Andrei Glavan,
  • David-Ioan Dumitrascu,
  • Andrei Adrian Popa,
  • Andrei Bordeianu and
  • Alexandru Vlad Ciurea

31 August 2023

This article presents a comprehensive review on migraine, a prevalent neurological disorder characterized by chronic headaches, by focusing on their pathogenesis and treatment advances. By examining molecular markers and leveraging imaging techniques...

  • Article
  • Open Access
114 Citations
20,954 Views
11 Pages

20 December 2022

This study sought to ascertain the prevalence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) among a sample of 465 patients with Long COVID. The participants completed three questionnaires: (1) a new questionnaire measuring both the f...

  • Review
  • Open Access
21 Citations
20,248 Views
11 Pages

The Role of Alpha-2 Agonists for Attention Deficit Hyperactivity Disorder in Children: A Review

  • Elisa E. Neuchat,
  • Brooke E. Bocklud,
  • Kali Kingsley,
  • William T. Barham,
  • Patrick M. Luther,
  • Shahab Ahmadzadeh,
  • Sahar Shekoohi,
  • Elyse M. Cornett and
  • Alan D. Kaye

Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders, characterized by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), which is marked by symptoms such...

  • Brief Report
  • Open Access
1 Citations
18,932 Views
7 Pages

Internal Tremor in Long COVID May Be a Symptom of Dysautonomia and Small Fiber Neuropathy

  • Svetlana Blitshteyn,
  • Ilene S. Ruhoy,
  • Lauren R. Natbony and
  • David S. Saperstein

Background/Objectives: Internal tremor (IT) is often reported by patients with post-acute sequelae of SARS-CoV-2, also known as Long COVID, as a distressing and disabling symptom. Similarly, physicians are typically perplexed by the nature and etiolo...

  • Review
  • Open Access
34 Citations
18,307 Views
21 Pages

The Management of Intracranial Aneurysms: Current Trends and Future Directions

  • Aviraj S. Deshmukh,
  • Stefano M. Priola,
  • Aris H. Katsanos,
  • Gianluca Scalia,
  • Aderaldo Costa Alves,
  • Abhilekh Srivastava and
  • Christine Hawkes

3 January 2024

Intracranial aneurysms represent a major global health burden. Rupture of an intracranial aneurysm is a catastrophic event. Without access to treatment, the fatality rate is 50% in the first 30 days. Over the last three decades, treatment approaches...

  • Review
  • Open Access
16 Citations
16,750 Views
18 Pages

Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID

  • Arman Fesharaki Zadeh,
  • Amy F. T. Arnsten and
  • Min Wang

Sustained cognitive deficits are a common and debilitating feature of “long COVID”, but currently there are no FDA-approved treatments. The cognitive functions of the dorsolateral prefrontal cortex (dlPFC) are the most consistently afflic...

  • Systematic Review
  • Open Access
11 Citations
16,442 Views
33 Pages

Mindfulness-Based Interventions and the Hypothalamic–Pituitary–Adrenal Axis: A Systematic Review

  • Hernando Vargas-Uricoechea,
  • Alejandro Castellanos-Pinedo,
  • Karen Urrego-Noguera,
  • Hernando D. Vargas-Sierra,
  • María V. Pinzón-Fernández,
  • Ernesto Barceló-Martínez and
  • Andrés F. Ramírez-Giraldo

20 November 2024

Background: Numerous studies have evaluated the effect that mindfulness-based interventions (MBIs) have on multiple health outcomes. For its part, stress is a natural response to environmental disturbances and within the associated metabolic response...

  • Review
  • Open Access
7 Citations
13,764 Views
19 Pages

Mucuna pruriens, a Possible Treatment for Depressive Disorders

  • Alfonso Mata-Bermudez,
  • Araceli Diaz-Ruiz,
  • Luis Ricardo Silva-García,
  • Eduardo Manuel Gines-Francisco,
  • Roxana Noriega-Navarro,
  • Camilo Rios,
  • Héctor Alonso Romero-Sánchez,
  • Diego Arroyo,
  • Abraham Landa and
  • Luz Navarro

16 November 2024

Depression is a mental disorder that depicts a wide variety of symptoms, including mood and cognitive alterations, as well as recurrent thoughts of death or suicide. It could become the second leading cause of premature death or disability worldwide....

  • Review
  • Open Access
1 Citations
13,650 Views
18 Pages

Cognitive Effects of Cannabis Use: A Comprehensive Review Across Domains

  • Andréia Pucinelli de Souza Queiroz,
  • Maria Olivia Pozzolo Pedro,
  • Marcela Waisman Campos,
  • Julio Torales,
  • Antonio Ventriglio and
  • João Mauricio Castaldelli-Maia

Cannabis is the most widely consumed illicit substance worldwide, with rising use particularly among adolescents and young adults. Accumulating evidence indicates that chronic cannabis use may negatively impact several domains of cognition, yet findi...

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Neurol. Int. - ISSN 2035-8377