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Viruses, Volume 17, Issue 5

May 2025 - 149 articles

Cover Story: Human papillomaviruses (HPVs) comprise a large family of non-enveloped DNA viruses. Common to most DNA viruses, deposition of the viral DNA within the host nucleus is necessary for infection. Unique to HPVs, this is accomplished through the delivery of relatively intact capsids within transport vesicles that associate with the host’s mitotic chromatin. In this study, we explored the ER as the source of these vesicles. HPV16 colocalized with components of the ER-generated COPII pathway and siRNA-mediated silencing of this pathway decreased infection. Interestingly, prevention of COPII-mediated egress from the ER resulted in relocalization of the capsids to vesicles containing the autophagic scaffold protein FIP200. We believe that these data reflect a balance between COPII vesicle generation and autophagosome biogenesis in HPV trafficking. View this paper
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Articles (149)

  • Article
  • Open Access
849 Views
11 Pages

19 May 2025

Human T cell leukemia virus type 1 (HTLV 1) is an oncogenic retrovirus responsible for the development of adult T cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes an oncoprotein named HTLV-1 bZIP factor (HBZ), which plays a pivotal ro...

  • Article
  • Open Access
1,380 Views
17 Pages

Uncovering SARS-CoV-2 Molecular Epidemiology Across the Pandemic Transition: Insights into Transmission in Clinical and Environmental Samples

  • Vrushali D. Patil,
  • Rashmi Chowdhary,
  • Anvita Gupta Malhotra,
  • Jitendra Singh,
  • Debasis Biswas,
  • Rajnish Joshi and
  • Jagat Rakesh Kanwar

19 May 2025

Background: Respiratory droplets are the main way in which the COVID-19 pandemic’s causal agent, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), spreads. Angiotensin-converting enzyme 2 (ACE2) receptors, especially in lung cells,...

  • Article
  • Open Access
1,315 Views
25 Pages

Discovery and Genome Characterization of Three New Rhabdoviruses Infecting Passiflora spp. in Brazil

  • Andreza Henrique Vidal,
  • Ana Clara Rodrigues Abreu,
  • Jorge Flávio Sousa Dantas-Filho,
  • Monique Jacob Xavier Vianna,
  • Cristiano Lacorte,
  • Emanuel Felipe Medeiros Abreu,
  • Gustavo Pereira Felix,
  • Dione Mendes Teixeira Alves-Freitas,
  • Bruna Pinheiro-Lima and
  • Isadora Nogueira
  • + 14 authors

19 May 2025

This study aimed to explore the RNA viruses affecting Passiflora species in Brazil. Our results enhance the understanding of the viruses that infect Passiflora plants by identifying and characterizing three previously unrecognized viruses: Passiflora...

  • Article
  • Open Access
1 Citations
1,250 Views
13 Pages

Evaluating Neutralizing Antibodies in Hantavirus-Infected Patients Using Authentic Virus and Recombinant Vesicular Stomatitis Virus Systems

  • Punya Shrivastava-Ranjan,
  • Jamie A. Kelly,
  • Laura K. McMullan,
  • Deborah Cannon,
  • Laura Morgan,
  • Payel Chatterjee,
  • Shilpi Jain,
  • Joel M. Montgomery,
  • Mike Flint and
  • César G. Albariño
  • + 1 author

19 May 2025

Hantaviruses, including the Sin Nombre virus (SNV) and Andes virus (ANDV), are associated with severe global health risks, causing high mortality rates in hantavirus pulmonary syndrome (HPS) patients. Neutralizing antibodies are essential for virus c...

  • Review
  • Open Access
2,204 Views
13 Pages

The Role of TDP-43 in SARS-CoV-2-Related Neurodegenerative Changes

  • Dong-Hwi Kim,
  • Jae-Hyeong Kim,
  • Min-Tae Jeon,
  • Kyu-Sung Kim,
  • Do-Geun Kim and
  • In-Soo Choi

19 May 2025

The coronavirus disease 2019 (COVID-19) pandemic has been linked to long-term neurological effects with multifaceted complications of neurodegenerative diseases. Several studies have found that pathological changes in transactive response DNA-binding...

  • Review
  • Open Access
6 Citations
3,689 Views
17 Pages

Evolution of Antiviral Drug Resistance in SARS-CoV-2

  • Roy Dinata,
  • Piyush Baindara and
  • Santi M. Mandal

18 May 2025

The COVID-19 pandemic has had a significant impact and continues to alarm the entire world due to the rapid emergence of new variants, even after mass vaccinations. There is still an urgent need for new antivirals or strategies to combat the SARS-CoV...

  • Article
  • Open Access
1,518 Views
14 Pages

Establishment and Implementation of the Point-of-Care RT-RAA-CRISPR/Cas13a Diagnostic Test for Foot-And-Mouth Disease Virus Serotype O in Pigs

  • Ping Meng,
  • Bo Ni,
  • Chenyu Li,
  • Zhou Sha,
  • Chunju Liu,
  • Weijie Ren,
  • Rong Wei,
  • Fuxiao Liu,
  • Jinming Li and
  • Zhiliang Wang

17 May 2025

Foot and mouth disease virus (FMDV) is a highly pathogenic virus that mainly infects cloven hooved animals, such as pigs. The establishment of a rapid, sensitive and accurate point-of-care detection method is critical for the timely identification an...

  • Article
  • Open Access
1 Citations
1,500 Views
12 Pages

Foscarnet Versus Ganciclovir for Severe Congenital Cytomegalovirus Infection: Short- and Long-Term Follow-Up

  • Giovanni Nigro,
  • Marta Buzzi,
  • Milena Catenaro,
  • Eleonora Coclite and
  • Mario Muselli

17 May 2025

Background: Cytomegalovirus (CMV) infection is the most common and serious congenital infection, with universal screening in pregnancy, standardized therapy, and a vaccine still lacking. Study design: In the 1990s, we noted that intravenous ganciclov...

  • Article
  • Open Access
2 Citations
1,360 Views
15 Pages

Characterization of Papillomatous Lesions and Genetic Diversity of Bovine Papillomavirus from the Amazon Region

  • Fernanda dos Anjos Souza,
  • Cíntia Daudt,
  • André de Medeiros Costa Lins,
  • Igor Ribeiro dos Santos,
  • Lorena Yanet Cáceres Tomaya,
  • Agnes de Souza Lima,
  • Eduardo Mitke Brandão Reis,
  • Rafael Augusto Satrapa,
  • David Driemeier and
  • Audrey Bagon
  • + 3 authors

16 May 2025

Bovine papillomaviruses (BPVs) have been widely characterized from cutaneous warts in cattle worldwide. However, there are still limited studies addressing the geographic distribution of viral types and their potential associations with the histopath...

  • Article
  • Open Access
1,419 Views
10 Pages

Assessing Urban Yellow Fever Transmission Risk: Aedes aegypti Vector Competence in Argentina

  • Estefanía R. Boaglio,
  • Evangelina Muttis,
  • Mariel Feroci,
  • Cintia Fabbri,
  • Graciela Minardi,
  • Juliana Sánchez,
  • María V. Micieli and
  • Silvina Goenaga

16 May 2025

Yellow fever is a viral disease with historical importance since epidemics caused thousands of deaths at the end of the 19th century in Argentina. That event was associated with the presence of Aedes aegypti. After the mosquito eradication in South A...

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Viruses - ISSN 1999-4915