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Viruses
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Hantavirus 2024
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Hantavirus 2024

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: closed (16 May 2025) | Viewed by 2016

Special Issue Editors

Dr. Heinz Feldmann

E-Mail Website
Guest Editor
Laboratory of Virology, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Interests: hemorrhagic fever viruses; diagnostics; treatments; vaccines; animal models
Special Issues, Collections and Topics in MDPI journals
Dr. David Safronetz

E-Mail Website
Guest Editor
Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada
Interests: hantaviruses; Lassa virus; Lujo virus; Crimean–Congo hemorrhagic fever virus
Dr. Bryce Warner

E-Mail Website
Guest Editor
Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5A2, Canada
Interests: virology; immunology; vaccines; Hantaviruses; Lassa virus; host-pathogen interactions; Viral Immunology; animal modelling
Dr. Kyle Rosenke

E-Mail Website
Guest Editor
Laboratory of Virology, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Interests: infectious disease; virology; animal models; therapeutics; vaccines

Special Issue Information

Dear colleagues,

The field of hantavirology is rapidly evolving. With the recent taxonomic updates and discoveries of hantaviruses in unique regions and reservoir hosts, many exciting changes have occurred over the last several years. Human disease, including hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome, associated with rodent-borne species, is causing significant morbidity and mortality in many parts of the world, with limited options for medical intervention. The impact on human health for newly discovered bat- and other non-rodent-borne viral species remains largely unknown, and collectively, like all zoonotic diseases, the true impact of climate change on hantaviral diseases remains to be seen. The present Special Issue covers recent developments in hantavirus research, with an emphasis on ecology, disease manifestations, medical intervention and diagnostic approaches. We openly invite submissions on these or other topics of interest to the hantavirus research community.

Dr. Heinz Feldmann
Dr. David Safronetz
Dr. Bryce Warner
Dr. Kyle Rosenke
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hantavirus
  • hantavirus cardiopulmonary syndrome
  • hemorrhagic fever with renal syndrome
  • ecology
  • disease manifestations
  • medical intervention
  • vaccines, therapeutics and clinical aspects

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Related Special Issue

Published Papers (3 papers)

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Research

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13 pages, 15467 KiB  
Article
Evaluating Neutralizing Antibodies in Hantavirus-Infected Patients Using Authentic Virus and Recombinant Vesicular Stomatitis Virus Systems
by Punya Shrivastava-Ranjan, Jamie A. Kelly, Laura K. McMullan, Deborah Cannon, Laura Morgan, Payel Chatterjee, Shilpi Jain, Joel M. Montgomery, Mike Flint, César G. Albariño and Christina F. Spiropoulou
Viruses 2025, 17(5), 723; https://doi.org/10.3390/v17050723 - 19 May 2025
Viewed by 201
Abstract
Hantaviruses, including the Sin Nombre virus (SNV) and Andes virus (ANDV), are associated with severe global health risks, causing high mortality rates in hantavirus pulmonary syndrome (HPS) patients. Neutralizing antibodies are essential for virus clearance and survival, making neutralization assays critical for understanding [...] Read more.
Hantaviruses, including the Sin Nombre virus (SNV) and Andes virus (ANDV), are associated with severe global health risks, causing high mortality rates in hantavirus pulmonary syndrome (HPS) patients. Neutralizing antibodies are essential for virus clearance and survival, making neutralization assays critical for understanding immunity and evaluating therapeutic strategies. In this study, we developed a recombinant vesicular stomatitis virus (VSV)-based surrogate system expressing SNV and ANDV glycoproteins (GPCs), enabling neutralization studies under biosafety level 2 conditions. The neutralization titers obtained with the VSV-based system closely matched the findings from authentic hantavirus assays performed under biosafety level 3 conditions, confirming its potential as a useful tool for determining immune responses and advancing hantavirus research. Full article
(This article belongs to the Special Issue Hantavirus 2024)
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11 pages, 2256 KiB  
Article
Novel Orthohantavirus Associated with Hantavirus Pulmonary Syndrome in Northern Argentina
by Carla M. Bellomo, Sebastian Kehl, Daniel Oscar Alonso, Walter López, Flavia Cassinelli, Rocío María Coelho, Gabriela Bravo, Sara Aguirre, Marcela Dib, Natalia Periolo, Concepción Toscano, José Gil, Francisco García Campos, Ignacio Ferro and Valeria Paula Martinez
Viruses 2025, 17(5), 717; https://doi.org/10.3390/v17050717 - 16 May 2025
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Abstract
In this work, we performed the genetic characterization of a new variant of orthohantavirus associated with a fatal case of hantavirus pulmonary syndrome, outside the known endemic region, in northwestern Argentina. We first confirmed an orthohantavirus infection by ELISA, testing for the detection [...] Read more.
In this work, we performed the genetic characterization of a new variant of orthohantavirus associated with a fatal case of hantavirus pulmonary syndrome, outside the known endemic region, in northwestern Argentina. We first confirmed an orthohantavirus infection by ELISA, testing for the detection of IgM and IgG antibodies. Then, we extracted RNA from 100 microliters of serum, the only sample available, followed by RT-PCR. The amplicons were sequenced using Sanger and next-generation sequencing technology. We obtained partial sequences of 1253 bp, 799 bp and 1675 bp from the S-, M- and L-segments, respectively, showing low sequence identities with all the previously characterized hantaviruses (10.9%, 13.5% and 15.1% of the divergence, respectively). The phylogenetic analysis showed that this virus belongs to the Orthohantavirus andesense species (ANDV), and among the ANDV-like variants, it is more closely related to the Lechiguanas clade. Similar percentages of divergence were considered sufficient to distinguish AND-like variants in previous works. As the patient had no travel history before the onset of disease was reported, we conducted rodent surveys to confirm the presence of reservoirs. The rodent assemblage was compatible with the transitional zone among different ecoregions (Yungas, Chaco and Monte). Moreover, one of the species captured, Oligoryzomys flavescens, was previously described as a reservoir of hantavirus. This species may either host several variants across its range or encompass a species complex, as proposed by some authors. Full article
(This article belongs to the Special Issue Hantavirus 2024)
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Review

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12 pages, 814 KiB  
Review
Clinical Manifestations of Hemorrhagic Fever with Renal Syndrome, Various Nosologic Forms and Issues of Hantavirus Infections Terminology
by Evgeniy Tkachenko, Tamara Dzagurova, Guzel Galieva, Victoria Ivanis, Svetlana Kurashova, Petr Tkachenko, Alexandra Balkina, Dmitriy Trankvilevsky and Aydar Ishmukhametov
Viruses 2025, 17(4), 578; https://doi.org/10.3390/v17040578 - 17 Apr 2025
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Abstract
Hemorrhagic fever with renal syndrome (HFRS) is the result of acute, zoonotic, natural foci hantavirus infections. It has serious social and medical importance due to its widespread distribution and the disease’s severity. There is a lack of effective etiotropic therapy and specific prophylaxis [...] Read more.
Hemorrhagic fever with renal syndrome (HFRS) is the result of acute, zoonotic, natural foci hantavirus infections. It has serious social and medical importance due to its widespread distribution and the disease’s severity. There is a lack of effective etiotropic therapy and specific prophylaxis available. The aim of this review is to observe the etiological, clinical, and epidemiological features of nosologic HFRS forms in Russia, as well as differences and similarities with hantavirus pulmonary syndrome (HPS). The various clinical HFRS manifestations characterized diseases associated with Puumala, Kurkino, and Sochi hantaviruses in the Russian European part, and with Hantaan, Amur, and Seoul hantaviruses in the Russian Far East. Differences were observed for HFRS foci types based on biological characteristics and natural host population dynamics. As a result of clinical and epidemiological analysis six nosological forms were established, all of which were classified as “hemorrhagic fever with renal syndrome” according to the WHO’s expert recommendation from 1983 year. The study showed comparable taxonomic characteristics and determined the mechanism of human infection course for HFRS and HPS. The accumulated knowledge of this study allows for the combination of HFRS and HPS names into a common logical disease name “Hantavirus fever”. Full article
(This article belongs to the Special Issue Hantavirus 2024)
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