Animal Models in Emerging/Re-Emerging Infectious Diseases

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 439

Special Issue Editor


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Guest Editor
Xianghu Laboratory, Hangzhou, China
Interests: emerging and re-emerging viral infectious diseases; virus-host interactions; pathogenic mechanisms of flaviviruses and coronaviruses; development of vaccines utilizing novel biomaterials

Special Issue Information

Dear Colleagues,

Animal models play a critical role in emerging/re-emerging infectious disease research, offering a robust platform for replicating the natural progression of human diseases. They are invaluable for studying the mechanisms of pathogenesis, providing insights into pathogen–host interactions, and evaluating the safety and efficacy of therapeutic interventions, including drugs and vaccines. However, physiological, genetic, and immunological differences between animals and humans can lead to variations in disease progression, drug metabolism, and immune response, posing challenges to the direct translation of findings to clinical settings.

This Special Issue highlights the significance of animal models in the study of emerging and re-emerging infectious diseases, focusing on understanding pathogen–host dynamics, advancing therapeutic development, and addressing the limitations of animal models through innovative technologies.

Dr. Dong Yang
Guest Editor

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Keywords

  • emerging/re-emerging infectious diseases
  • animal models
  • pathogen–host interactions, pathogenesis
  • interventions
  • drugs
  • vaccines

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Published Papers (1 paper)

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Research

15 pages, 1837 KiB  
Article
Characterization of an Emerging Recombinant Duck Circovirus in Northern Vietnam, 2023–2024
by Hieu Van Dong, Dai Quang Trinh, Giang Huong Thi Tran, Thanh Thi Vu, Thinh Hung Ba Nguyen, Amonpun Rattanasrisomporn, Dao Anh Tran Bui and Jatuporn Rattanasrisomporn
Viruses 2025, 17(5), 732; https://doi.org/10.3390/v17050732 - 20 May 2025
Viewed by 319
Abstract
This study aimed to characterize the duck circovirus circulating in Northern Vietnam based on complete genome sequences. Between 2023 and 2025, 45 pooled tissue samples were collected from nine duck flocks in several provinces in Northern Vietnam. Of the 45 samples tested, 16 [...] Read more.
This study aimed to characterize the duck circovirus circulating in Northern Vietnam based on complete genome sequences. Between 2023 and 2025, 45 pooled tissue samples were collected from nine duck flocks in several provinces in Northern Vietnam. Of the 45 samples tested, 16 (35.56%) were positive for the DuCV genome, as determined using conventional polymerase chain reaction. Nine representative strains were selected for viral genome sequencing. The results indicated that the complete Vietnamese DuCV genomes were from 1992 to 1995 bp in length, and the degree of nucleotide identity shared among them ranged from 96.88% to 99.84%. Phylogenetic analysis of the complete genomes showed that the nine Vietnamese DuCV strains belonged to genotype I, subgenotypes Ia (two strains), Ib (four strains), and Ic (three strains). These viral strains were genetically related to viruses reported in China from 2019 to 2023. Recombination events occurred on the Cap gene sequences of three Vietnamese DuCV strains (Vietnam/VNUA-102/2023, Vietnam/VNUA-225/2023, and Vietnam/VNUA-318/2024). One positive selection was detected on the Rep protein sequence. Full article
(This article belongs to the Special Issue Animal Models in Emerging/Re-Emerging Infectious Diseases)
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