Viruses, Volume 11, Issue 11 (November 2019) – 109 articles
Cover Story (view full-size image): The Zika virus circulates between vertebrate hosts and mosquito vectors, both of which need to be productively infected. During mosquito infection, the virus encounters several tissue barriers, one of them between the midgut and other tissues. We investigated how Zika virus is overcoming this midgut escape barrier. We revealed the mesh width of the midgut basal lamina as a critical factor, which remains enlarged after bloodmeal digestion, enabling the virus to escape from the organ.View this paper.
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