Next Article in Journal
Characterization and Pathogenicity of the Porcine Deltacoronavirus Isolated in Southwest China
Next Article in Special Issue
Avian Flavivirus Enters BHK-21 Cells by a Low pH-Dependent Endosomal Pathway
Previous Article in Journal
Support for the Transmission-Clearance Trade-Off Hypothesis from a Study of Zika Virus Delivered by Mosquito Bite to Mice
Previous Article in Special Issue
Erythromycin Estolate Inhibits Zika Virus Infection by Blocking Viral Entry as a Viral Inactivator
Open AccessReview

Towards Understanding KSHV Fusion and Entry

Biological Mimetics Inc., 124 Byte Drive, Frederick, MD 21702, USA
Viruses 2019, 11(11), 1073;
Received: 30 September 2019 / Revised: 10 November 2019 / Accepted: 14 November 2019 / Published: 18 November 2019
(This article belongs to the Special Issue Viral Entry Pathways)
How viruses enter cells is of critical importance to pathogenesis in the host and for treatment strategies. Over the last several years, the herpesvirus field has made numerous and thoroughly fascinating discoveries about the entry of alpha-, beta-, and gamma-herpesviruses, giving rise to knowledge of entry at the amino acid level and the realization that, in some cases, researchers had overlooked whole sets of molecules essential for entry into critical cell types. Herpesviruses come equipped with multiple envelope glycoproteins which have several roles in many aspects of infection. For herpesvirus entry, it is usual that a collective of glycoproteins is involved in attachment to the cell surface, specific interactions then take place between viral glycoproteins and host cell receptors, and then molecular interactions and triggers occur, ultimately leading to viral envelope fusion with the host cell membrane. The fact that there are multiple cell and virus molecules involved with the build-up to fusion enhances the diversity and specificity of target cell types, the cellular entry pathways the virus commandeers, and the final triggers of fusion. This review will examine discoveries relating to how Kaposi’s sarcoma-associated herpesvirus (KSHV) encounters and binds to critical cell types, how cells internalize the virus, and how the fusion may occur between the viral membrane and the host cell membrane. Particular focus is given to viral glycoproteins and what is known about their mechanisms of action. View Full-Text
Keywords: KSHV; virus entry; fusion; glycoprotein B; glycoprotein H; K8.1; tropism; Ephrin Receptor; Integrin; B cell KSHV; virus entry; fusion; glycoprotein B; glycoprotein H; K8.1; tropism; Ephrin Receptor; Integrin; B cell
Show Figures

Figure 1

MDPI and ACS Style

Dollery, S.J. Towards Understanding KSHV Fusion and Entry. Viruses 2019, 11, 1073.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop