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Open AccessReview

Parechovirus A Pathogenesis and the Enigma of Genotype A-3

1
Laboratory of Clinical Virology, Department of Medical Microbiology, Amsterdam UMC, location Academic Medical Center, University of Amsterdam, 1100 AZ Amsterdam, The Netherlands
2
Department of Pediatrics, Emma Children’s Hospital, Amsterdam UMC, location Academic Medical Center, University of Amsterdam, 1100 AZ Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2019, 11(11), 1062; https://doi.org/10.3390/v11111062
Received: 14 October 2019 / Revised: 12 November 2019 / Accepted: 12 November 2019 / Published: 14 November 2019
(This article belongs to the Special Issue Human Picornaviruses)
Parechovirus A is a species in the Parechovirus genus within the Picornaviridae family that can cause severe disease in children. Relatively little is known on Parechovirus A epidemiology and pathogenesis. This review aims to explore the Parechovirus A literature and highlight the differences between Parechovirus A genotypes from a pathogenesis standpoint. In particular, the curious case of Parechovirus-A3 and the genotype-specific disease association will be discussed. Finally, a brief outlook on Parechovirus A research is provided. View Full-Text
Keywords: parechovirus; parechovirus A; parechovirus A-3; pathogenesis parechovirus; parechovirus A; parechovirus A-3; pathogenesis
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Sridhar, A.; Karelehto, E.; Brouwer, L.; Pajkrt, D.; Wolthers, K.C. Parechovirus A Pathogenesis and the Enigma of Genotype A-3. Viruses 2019, 11, 1062.

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