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HBV Infection in HIV-Driven Immune Suppression

Clinical Infectious Diseases, Department of System Medicine, Tor Vergata University, 00133 Rome, Italy
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Viruses 2019, 11(11), 1077; https://doi.org/10.3390/v11111077
Received: 22 October 2019 / Revised: 15 November 2019 / Accepted: 16 November 2019 / Published: 19 November 2019
(This article belongs to the Special Issue Hepatitis B Virus Reactivation)
Worldwide, approximately 10% of all human immunodeficiency virus (HIV)-infected people are also chronically coinfected with hepatitis B virus (HBV). HBV infection has a poor prognosis in HIV-positive people and has been documented by an increased risk of developing chronic HBV infection (CHB), progression to liver fibrosis and end-stage liver disease (ESLD) and evolution of hepatocellular carcinoma (HCC). Furthermore, in HIV patients, HBV-resolved infection is often associated with the appearance of HBV-DNA, which configures occult HBV infection (OBI) as a condition to be explored in coinfected patients. In this narrative review we summarize the main aspects of HBV infection in HIV-positive patients, emphasizing the importance of carefully considering the coinfected patient in the context of therapeutic strategies of antiretroviral therapy. View Full-Text
Keywords: hepatitis B virus; HIV/HBV coinfection; end-stage liver disease; hepatocellular carcinoma; occult HBV infection hepatitis B virus; HIV/HBV coinfection; end-stage liver disease; hepatocellular carcinoma; occult HBV infection
MDPI and ACS Style

Sarmati, L.; Malagnino, V. HBV Infection in HIV-Driven Immune Suppression. Viruses 2019, 11, 1077.

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