Special Issue "Bacteriophages and Biofilms"
Deadline for manuscript submissions: closed (15 December 2019).
Interests: biofilm; phage-host interactions; phage-borne enzymes; alternative antibacterial therapies
Biofilms are a community of surface-associated microorganisms embedded within a matrix of extracellular polymeric substances (EPS—extracellular polymeric substances) composed essentially of polysaccharides, eDNA, and proteins. These multicellular communities are characterised by the presence of different cell types in terms of physiology and phenotype.
Persister cells are much more abundant in biofilms compared to planktonic culture; therefore, it is important to understand persister cells interactions with domesticated phages (prophages) as well as with lytic ones. Phages are actively involved in biofilm formation, in two different ways: as promoting or degrading agents. Phages can be equipped with matrix-degrading enzymes and effectively infect biofilm-embedded cells. In this meaning, phages are a natural and helpful weapon against microbial biofilms. On the other hand, prophages regulate phage-mediated cell lysis and eDNA release, an important component of stabilizing the biofilm matrix.
The ability to form biofilms and to modify virulence in response to environmental changes is coordinated by complex bacterial signaling networks such as two-component systems (TCS), secondary messengers involved in quorum sensing (QS), and c-di-GMP networks (diguanylate cyclase systems, DGC). Signal cascades dynamically control the transition from free-living to the sessile mode of growth in response to external environment changes, including viral infection. Therefore, it is interesting to understand the interaction of phages with the bacterial signaling network.
In this Special Issue, we are looking for reports and reviews of the most current findings on the phage role in bacterial biofilms formation, maintenance, and degradation. We welcome the submission of original research, reviews, and mini-reviews covering but not limited to the following topics:
- The influence of phages in regulating biofilm initiation, development, function, and dispersal;
- Phage-mediated horizontal gene transfer within the sessile community;
- Phage-phage interactions and communication in multicellular bacterial communities;
- The role of phages in regulating the bacterial signaling network and intercellular interactions;
- Phage propagation regulation/preferences during the infection of biofilm-forming bacteria;
- Anti-viral infection mechanisms of sessile cells;
- Phage influence on the physiology and fitness of biofilm communities;
- The development of novel strategies for preventing or controlling biofilm formation based on phage products.
Dr. Zuzanna Drulis-Kawa
Dr. Barbara Maciejewska
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- phage-sessile cells interactions
- persister cells
- anti-phage mechanisms of biofilm-living bacteria
- anti-biofilm treatment
- phage-based pro-biofilm activity