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Open AccessArticle

Survey and Characterization of Jingmen Tick Virus Variants

1
Research and Application Center, Advanced Technology Education, Mersin University, Mersin 33110, Turkey
2
Department of Virology, Faculty of Veterinary Medicine, Ankara University, Ankara 06110, Turkey
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Department of Biology, Namık Kemal University, Tekirdağ 33110, Turkey
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Department of Microbiology and Immunology and Galveston National Laboratory, University of Texas Medical Branch, Galveston, GX 77555, USA
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Virology Unit, Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey
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Center for Biological Threats and Special Pathogens 1 (ZBS-1), Robert Koch Institute, 13352 Berlin, Germany
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Department of Entomology, Smithsonian Institution-National Museum of Natural History, Washington, DC 20560, USA
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Walter Reed Biosystematics Unit, Smithsonian Institution Museum Support Center, Suitland, MD 20746, USA
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(11), 1071; https://doi.org/10.3390/v11111071
Received: 24 October 2019 / Accepted: 5 November 2019 / Published: 17 November 2019
(This article belongs to the Special Issue Emerging Arboviruses)
We obtained a Jingmen tick virus (JMTV) isolate, following inoculation of a tick pool with detectable Crimean-Congo hemorrhagic fever virus (CCHFV) RNA. We subsequently screened 7223 ticks, representing 15 species in five genera, collected from various regions in Anatolia and eastern Thrace, Turkey. Moreover, we tested specimens from various patient cohorts (n = 103), and canine (n = 60), bovine (n = 20) and avian specimens (n = 65). JMTV nucleic acids were detected in 3.9% of the tick pools, including those from several tick species from the genera Rhipicephalus and Haemaphysalis, and Hyalomma marginatum, the main vector of CCHFV in Turkey. Phylogenetic analysis supported two separate clades, independent of host or location, suggesting ubiquitous distribution in ticks. JMTV was not recovered from any human, animal or bird specimens tested. Near-complete viral genomes were sequenced from the prototype isolate and from three infected tick pools. Genome topology and functional organization were identical to the members of Jingmen group viruses. Phylogenetic reconstruction of individual viral genome segments and functional elements further supported the close relationship of the strains from Kosovo. We further identified probable recombination events in the JMTV genome, involving closely-related strains from Anatolia or China. View Full-Text
Keywords: jingmen; tick; flavivirus; Anatolia; turkey jingmen; tick; flavivirus; Anatolia; turkey
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MDPI and ACS Style

Dinçer, E.; Hacıoğlu, S.; Kar, S.; Emanet, N.; Brinkmann, A.; Nitsche, A.; Özkul, A.; Linton, Y.-M.; Ergünay, K. Survey and Characterization of Jingmen Tick Virus Variants. Viruses 2019, 11, 1071.

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