Int. J. Mol. Sci., Volume 19, Issue 3 (March 2018) – 278 articles
Cover Story (view full-size image): Tyrosinase is the key enzyme of melanin production in melanosomes, which are transferred from epidermal melanocytes to keratinocytes. Inhibitors of tyrosinase are of great clinical interest for the treatment of hyperpigmentation. However, most inhibitors described in the literature were only tested on mushroom tyrosinase and thus lack clinical efficacy. In the present study, a recombinant soluble human tyrosinase was used to analyze the structure–activity relationships of thiazolyl resorcinols, a novel class of tyrosinase inhibitor. View the paper here.
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