Galectins in Cancer and Translational Medicine
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 November 2017) | Viewed by 141299
A printed edition of this Special Issue is available here.
Interests: tumor pathology; molecular pathology; cell biology; thyroid cancer; melanoma; solid tumors; molecular targeted therapy; monoclonal antibodies; immunochemistry; immunohistochemistry; galectins; CD44; integrins, adhesion molecules; cell–ECM interactions
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In the post-genomic era, many efforts have been devoted to better understand the biological information encoded by the cell “glycome” in normal and pathologic conditions. The glycan signature of human cells plays a pivotal role in regulating fundamental biological processes, which are critical for cell physiology and for cancer as well.
Galectins (also worded S-type lectins) are an evolutionarily conserved family of endogenous lectins, which bind carbohydrates with high specificity. These molecules, which can be found both intracellularly and in the extracellular milieu, are functionally active in converting glycan-containing information into cell biological programs. This fashionable mechanism of signal transduction plays a relevant role in regulating several biological functions, among which RNA splicing, gene transcription, cell migration and differentiation, apoptosis, immune response and tumor growth and progression.
It is not surprising, indeed, that a large number of studies on galectin–glycan interactions and galectins expression and function in human diseases have been published in the recent literature, spanning from immunology to cardiovascular medicine, from diagnostic Pathology to nuclear medicine.
The aim of this Special Issue of IJMS is to collect selected contributes in the field reporting data, concepts and new ideas, which have the potential to be translated in the clinical setting in a near future, in order to improve the diagnosis and treatment of cancer and other relevant human diseases.
Prof. Dr. Armando Bartolazzi
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- galectins in diagnosis
- galectins in therapy
- galectins and immunity
- galectins and cancer
- galectins and human diseases