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Int. J. Mol. Sci. 2018, 19(3), 905; https://doi.org/10.3390/ijms19030905

Galectins as Molecular Targets for Therapeutic Intervention

1
Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
2
Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
*
Author to whom correspondence should be addressed.
Received: 27 February 2018 / Revised: 14 March 2018 / Accepted: 15 March 2018 / Published: 19 March 2018
(This article belongs to the Special Issue Galectins in Cancer and Translational Medicine)
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Abstract

Galectins are a family of small, highly conserved, molecular effectors that mediate various biological processes, including chemotaxis and angiogenesis, and that function by interacting with various cell surface glycoconjugates, usually targeting β-galactoside epitopes. Because of their significant involvement in various biological functions and pathologies, galectins have become a focus of therapeutic discovery for clinical intervention against cancer, among other pathological disorders. In this review, we focus on understanding galectin structure-function relationships, their mechanisms of action on the molecular level, and targeting them for therapeutic intervention against cancer. View Full-Text
Keywords: galectins; carbohydrates; apoptosis; cell adhesion; protein structure; cancer; galectin-targeted therapeutics galectins; carbohydrates; apoptosis; cell adhesion; protein structure; cancer; galectin-targeted therapeutics
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Dings, R.P.M.; Miller, M.C.; Griffin, R.J.; Mayo, K.H. Galectins as Molecular Targets for Therapeutic Intervention. Int. J. Mol. Sci. 2018, 19, 905.

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