Galectins as Molecular Targets for Therapeutic Intervention
AbstractGalectins are a family of small, highly conserved, molecular effectors that mediate various biological processes, including chemotaxis and angiogenesis, and that function by interacting with various cell surface glycoconjugates, usually targeting β-galactoside epitopes. Because of their significant involvement in various biological functions and pathologies, galectins have become a focus of therapeutic discovery for clinical intervention against cancer, among other pathological disorders. In this review, we focus on understanding galectin structure-function relationships, their mechanisms of action on the molecular level, and targeting them for therapeutic intervention against cancer. View Full-Text
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Dings, R.P.M.; Miller, M.C.; Griffin, R.J.; Mayo, K.H. Galectins as Molecular Targets for Therapeutic Intervention. Int. J. Mol. Sci. 2018, 19, 905.
Dings RPM, Miller MC, Griffin RJ, Mayo KH. Galectins as Molecular Targets for Therapeutic Intervention. International Journal of Molecular Sciences. 2018; 19(3):905.Chicago/Turabian Style
Dings, Ruud P.M.; Miller, Michelle C.; Griffin, Robert J.; Mayo, Kevin H. 2018. "Galectins as Molecular Targets for Therapeutic Intervention." Int. J. Mol. Sci. 19, no. 3: 905.
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