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Int. J. Mol. Sci. 2018, 19(3), 895; https://doi.org/10.3390/ijms19030895

Dietary Quercetin Attenuates Adipose Tissue Expansion and Inflammation and Alters Adipocyte Morphology in a Tissue-Specific Manner

1
Nutrient Sensing and Adipocyte Signaling Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
2
Biology Department, Franciscan Missionaries of Our Lady University, Baton Rouge, LA 70808, USA
3
School of Sport and Exercise Sciece, University of Northern Colorado, Greeley, CO, 80639, USA
4
Nutrition Science, Purdue University, West Lafayette, IN 47907, USA
These authors contributed equally as senior authors.
*
Author to whom correspondence should be addressed.
Received: 31 December 2017 / Revised: 15 March 2018 / Accepted: 16 March 2018 / Published: 17 March 2018
(This article belongs to the Special Issue Nutraceuticals in Human Health and Disease)
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Abstract

Chronic inflammation in adipose tissue may contribute to depot-specific adipose tissue expansion, leading to obesity and insulin resistance. Dietary supplementation with quercetin or botanical extracts containing quercetin attenuates high fat diet (HFD)-induced obesity and insulin resistance and decreases inflammation. Here, we determined the effects of quercetin and red onion extract (ROE) containing quercetin on subcutaneous (inguinal, IWAT) vs. visceral (epididymal, EWAT) white adipose tissue morphology and inflammation in mice fed low fat, high fat, high fat plus 50 μg/day quercetin or high fat plus ROE containing 50 μg/day quercetin equivalents for 9 weeks. Quercetin and ROE similarly ameliorated HFD-induced increases in adipocyte size and decreases in adipocyte number in IWAT and EWAT. Furthermore, quercetin and ROE induced alterations in adipocyte morphology in IWAT. Quercetin and ROE similarly decreased HFD-induced IWAT inflammation. However, quercetin and red onion differentially affected HFD-induced EWAT inflammation, with quercetin decreasing and REO increasing inflammatory marker gene expression. Quercetin and REO also differentially regulated circulating adipokine levels. These results show that quercetin or botanical extracts containing quercetin induce white adipose tissue remodeling which may occur through inflammatory-related mechanisms. View Full-Text
Keywords: quercetin; inflammation; browning; mulilocular adipocyte; red onion extract; botanical extract; adipose tissue; adipocyte; adipokine quercetin; inflammation; browning; mulilocular adipocyte; red onion extract; botanical extract; adipose tissue; adipocyte; adipokine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Forney, L.A.; Lenard, N.R.; Stewart, L.K.; Henagan, T.M. Dietary Quercetin Attenuates Adipose Tissue Expansion and Inflammation and Alters Adipocyte Morphology in a Tissue-Specific Manner. Int. J. Mol. Sci. 2018, 19, 895.

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