Special Issue "Human Polyomaviruses and Papillomaviruses"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 February 2018)
A printed edition of this Special Issue is available here.
Human polyomaviruses (HPyV) and papillomaviruses (HPV) are small, non-enveloped viruses with a dsDNA of approximately 5 kbp and 8 kbp, respectively. They belong to the families Polyomaviridae and Papillomaviridae, respectively. Their members can infect mammals and birds, and, recently, polyomavirus and papillomavirus DNA has been detected in reptiles and fish. About 100 different subtypes of HPV are known, while, presently, 14 different polyomaviruses have been isolated in humans. While several HPV subtypes are known to play a causal role in anogenital and oropharyngeal cancers, only one, HPyV, seems to be associated with malignancy. Merkel cell polyomavirus is present in about 80% of all Merkel cell carcinomas, an aggressive type of skin cancer. The incidences of Merkel cell carcinoma and HPV-associated oropharyngeal carcinoma cases are increasing. Vaccines against the most common high-risk HPVs are now available as a prophylactic treatment. Immunotherapy-based clinical trial with Merkel cell carcinoma patients have shown promising results; however, there is an urgent need for additional anti-HPV and anti-HPyV therapies.
This Special Issue on “Human Polyomaviruses and Papillomaviruses” focuses on the role of HPyV and HPV in disease, their life cycles, host–cell interaction, mechanisms of oncogenesis, and anti-viral therapies. Topics may also include epidemiology, structure, screening, disease management and other aspects of HPyV and HPV. This Special Issue will include original research and review papers.
Prof. Dr. Ugo Moens
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Host cell interaction
- Anti-viral therapy
- Cell tropism