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Amino Acid Transporters and Glutamine Metabolism in Breast Cancer

Department of Pathology, Yonsei University College of Medicine, Seoul, 03722, Korea
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Int. J. Mol. Sci. 2018, 19(3), 907; https://doi.org/10.3390/ijms19030907
Received: 6 February 2018 / Revised: 15 March 2018 / Accepted: 18 March 2018 / Published: 19 March 2018
(This article belongs to the Special Issue Amino Acids Transport and Metabolism)
Amino acid transporters are membrane transport proteins, most of which are members of the solute carrier families. Amino acids are essential for the survival of all types of cells, including tumor cells, which have an increased demand for nutrients to facilitate proliferation and cancer progression. Breast cancer is the most common malignancy in women worldwide and is still associated with high mortality rates, despite improved treatment strategies. Recent studies have demonstrated that the amino acid metabolic pathway is altered in breast cancer and that amino acid transporters affect tumor growth and progression. In breast cancer, glutamine is one of the key nutrients, and glutamine metabolism is closely related to the amino acid transporters. In this review, we focus on amino acid transporters and their roles in breast cancer. We also highlight the different subsets of upregulated amino acid transporters in breast cancer and discuss their potential applications as treatment targets, cancer imaging tracers, and drug delivery components. Glutamine metabolism as well as its regulation and therapeutic implication in breast cancer are also discussed. View Full-Text
Keywords: amino acid transporters; human pathology; breast cancer; transport mechanism amino acid transporters; human pathology; breast cancer; transport mechanism
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MDPI and ACS Style

Cha, Y.J.; Kim, E.-S.; Koo, J.S. Amino Acid Transporters and Glutamine Metabolism in Breast Cancer. Int. J. Mol. Sci. 2018, 19, 907.

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