Special Issue "Spleen: Crossroad between Immune System, Metabolic Asset and Endocrine Function"
Deadline for manuscript submissions: closed (28 February 2018)
Prof. Dr. Giovanni Tarantino
Department of Clinical Medicine and Surgery, University of Naples Federico II | UNINA , Naples, Italy
Website | E-Mail
Interests: nonalcoholic fatty liver disease; metabolic syndrome; obesity; atherosclerosis and NAFLD; PCOS and NAFLD; HCV-related chronic hepatitis; HCV-related arthritis; therapy of liver cirrhosis; portal hypertension; hepatic encephalopathy; imaging-ultrasonography of liver and spleen; psoriatic arthritis and NAFLD; cytokines in obesity
Due to the view that the “spleen is useless”, research on this organ has lagged behind that of other organs. Since 1952, when King and Schumacker reported overwhelming post-splenectomy infection, there has been a growing recognition of the importance of the spleen in the human body. On the other hand, physicians often encounter spleen enlargement, i.e., splenomegaly, which is almost always a consequence of other disorders. Hypersplenism is a secondary process that can arise from splenomegaly of almost any cause. In recent years, following in-depth studies of spleen organization and structure, cell function, secretion and innervations, a better understanding of the function of the spleen has been gained. It was initially accepted that the spleen not only filters blood, but, rather, is an important regulation center of the body’s immune-metabolic-endocrine network. However, a number of questions have arisen: Is the spleen a player or a bystander, and what are the roles of some cytokines, adipokines/growth factors and neurotransmitters in this complex mechanism? Furthermore, what is the contribution of the spleen to obesity-related diseases? Finally, does spleen contribute to the complex network between trace elements or environmental particulate matter and immunity?
Prof. Dr. Giovanni Tarantino
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
vitamin D and spleen
mechanisms linking spleen and obesity-related diseases (NAFLD, OSAS, PCOS)
trace elements/immunity and spleen
environmental particulate matter/immunity and spleen