PPARs in Cellular and Whole Body Energy Metabolism

Dear Colleagues,

All three peroxisome proliferator-activated receptor (PPAR) isotypes α, β/δ and γ, function as sensors for fatty acids and fatty acid derivatives, and control important metabolic pathways regulating cellular and whole body energy homeostasis. These ligand-dependent transcription factors, which belong to the nuclear receptor superfamily of transcription factors, have been targeted to fight metabolic diseases based on their metabolic regulatory activities in various tissues, in part depending on ligand selectivity. In fact, PPARs act as modulators of cellular, organ, and systemic processes, including lipid and carbohydrate metabolism, making them valuable for maintaining body homeostasis, particularly under the influence of nutrition and exercise. Each organ has a unique metabolic arrangement. For instance, the metabolic patterns of the liver, muscle, brain, adipose tissue, and kidney, are markedly different and these organs strikingly differ in their use of fuels to meet their energy needs. Furthermore, tumours also have their own metabolic processes that differ from those of noncancerous cells. Lastly, the energy substrates have also specific characteristics that require adaptive strategies. This Special Issue of IJMS will cover the singular and intricate regulatory roles of all three PPAR isotypes in the ensemble of processes that are associated with metabolism in the healthy and diseased organism.

Prof. Walter Wahli
Ms. Rachel Tee
Guest Editors

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