Molecules, Volume 31, Issue 14

A monocrystal of the natural mineral hambergite, Be₂BO₃OH, is studied by ¹⁰B-NMR spectroscopy. The nuclide ¹⁰B possesses spin $I=3$, and thus for a single boron site in a periodic solid, the ¹⁰B spectrum is composed of three doublets. For the four inve...

The ternary strategy has emerged as an effective approach to enhance the photovoltaic performance of organic solar cells (OSCs), yet simultaneously improving both efficiency and stability remains a formidable challenge. Herein, we report a small-mole...

In recent years, innovative edible vegetal products, obtained by harvesting in the early stages of plant development, have emerged for their potential as sources of nutraceuticals. Phytosterols, which play important structural and regulatory roles in...

Breast cancer remains one of the most prevalent malignancies affecting women worldwide and continues to be a leading cause of cancer-related morbidity and mortality. Patients may present with either localized or advanced disease, with clinical outcom...

Natural products represent a valuable source of anticancer agents, although their mechanisms of action are often incompletely understood. In this study, we evaluated the cytotoxic effects of the ethyl acetate (EA) fraction derived from Schima superba...

The therapeutic use of Taraxacum officinale L. remains a challenge due to its chemical profile shifting dramatically, markedly with seasonal variation and processing techniques. To address this, the paper evaluated how the plant organ, harvest season...

Lung cancer represents a substantial global oncology burden, exhibiting mortality rates that surpass those of prostate, pancreatic, and breast cancers. Extensive research has established a correlation between exposure to polycyclic aromatic hydrocarb...

Potato starch extrudates, chemically modified by a K₂CO₃ catalyst and enriched with two types of edible oils (rapeseed or sunflower) at varying concentrations (3%, 6%, 9%), were used as film substrates. This study was carried out as a continuation of...

Agro-industrial by-products from beetroot, raspberry, sea buckthorn, and shadbush are valuable sources of natural pigments and renewable filler materials, but their hydrophilic surfaces limit compatibility with hydrophobic polydimethylsiloxane (PDMS)...

The emergence of antimicrobial resistance necessitates the development of structurally novel agents with improved biological profiles. In this study, a series of new derivatives of fluconazole were designed, synthesized, and evaluated for antifungal...

Octyl (N-(5-(1H-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamate has previously been characterized as substrate-specific inhibitor of the linoleic acid oxygenase activity of mammalian ALOX15 orthologs. Here we aimed at optimizing the inhibitory proper...

Wheat milling by-products are nutrient-rich sidestreams whose valorization is limited by low phenolic bioaccessibility and high phytate levels. This study investigates how sourdough fermentation using a mixed starter (Lactiplantibacillus plantarum, S...

The demand for sustainable nutrients and bioactive compounds has increased interest in underutilized wild plants. Forestiera tomentosa, a Mexican drupe-bearing species, is largely unexplored. This study evaluated the proximate composition, physicoche...

Plasma proteins are becoming more and more popular among researchers due to their minimal toxicity and immunogenicity. The largest percentage of plasma proteins is human serum albumin (HSA). HSA is widely used as a drug carrier due to its biocompatib...

Oral administration of narrow therapeutic index anticoagulants like phenprocoumon (PHP) necessitates careful control of the kinetic release of the drug to avoid dose dumping and severe haemorrhagic effects. This study was carried out to prepare and c...

Quercetin, a plant-derived flavonoid with potent antioxidant and anti-inflammatory properties, is limited for topical use by its poor aqueous solubility, low bioavailability, and chemical instability. This research developed and validated a formulati...

In this study, novel and stable cellulose-based oleogels with tunable rheological properties were successfully developed for lubrication applications via cross-linking reactions of epoxidized soybean oil (ESO), microcrystalline cellulose (MCC), and i...

Streptomyces-derived pigments are promising bioactive metabolites for cosmeceutical applications due to their antimicrobial potential; however, their stability may be affected by environmental conditions. This study evaluated the antibacterial activi...

Encapsulation of resveratrol (RVT), a natural polyphenol, in mixed Pluronic F127/P123 micelles (mRVT) has enhanced its pharmacological efficacy in experimental dementia models. The aim of this study was to evaluate neurochemical and behavioral parame...

Single-needle electrospinning and needle-free electrospinning were applied to fabricate cellulose acetate (CA) fibrous mats containing rosemary (RO), clove (CL) and thyme (TH) essential oils (EO) from binary or ternary solvent mixture solutions. When...

Valproic acid is a clinically important therapeutic agent whose biological properties have stimulated the development of structurally modified derivatives with improved pharmacological profiles. In the present study, nine amino–valproic acid hy...

Calcium- and iron-rich sludge from urban storm sewer is an ideal source of phosphorus adsorbents. This study used urban storm sewer sludge to prepare phosphorus adsorbents via pyrolysis. Comparing adsorbents prepared under different conditions, the o...

Driven by the growing demand for quality assurance within the essential oil (EO) industry, this study builds upon prior seasonal chemical and anticholinergic characterizations of Azorean Cryptomeria japonica foliage (Az–CJF) EO by presently eva...

The environmental crisis caused by hydrocarbon-contaminated sediment from the oil industry remains a pressing concern. While sediment microbial fuel cells (SMFCs) offer a potential remediation strategy, they suffer from low power densities and high i...

The substantial volume of agrifood processing side streams represents a global sustainability challenge that requires transformation of agricultural residues into high-value molecular components. Grape pomace (GP) is a major winemaking co-product who...

The objective of this study was to evaluate the antioxidant and antibacterial profiles of Picea orientalis (Oriental spruce) resin extracts collected from three distinct geographical sites (Artvin, Borçka, and Çaykara) within the Easter...

In the original publication [...]

Crystal structural stability is one of the core indicators for evaluating the safety of energetic materials, since these energetic materials undergo complex environments during manufacturing, processing, transportation, storage, and application in we...

Two thiourea-based chiral solvating agents (CSAs), S-1 and S-2, were evaluated for the enantiomeric discrimination of representative α-arylacetic acids by ¹H NMR spectroscopy in the presence of DMAP. Enantiomeric discrimination was assessed by...

Functionalized nitrile oxides have attracted increasing attention because the incorporated functional groups not only influence cycloaddition reactivity but also provide valuable handles for subsequent molecular diversification. Despite their conside...

Background: With the increase in the middle-aged population and sedentary lifestyle, a high incidence of obesity has been observed in humans and in animals. Obesity is consequent or correlated to multiple diseases, such as metabolic-dysfunction-assoc...

Oxidative stress and antioxidant enzyme activity play a major role in the development of numerous chronic diseases. Edible plants and herbs are rich in polyphenols and other bioactive compounds that may protect cells by neutralizing free radicals and...

Magnesium-based materials remain among the most intensively studied solid-state hydrogen storage systems because they combine high theoretical hydrogen capacity, elemental abundance, and comparatively low cost. Yet their practical performance is stil...

Polyethylene glycol (PEG) has been recognized as an environmentally friendly solvent in chemical synthesis. To better understand how PEG behaves as a chemical solvent, this study focuses on cyclohexane as a solute, which is only sparingly soluble in...

Gastric cancer is among the leading causes of cancer-related deaths worldwide. Modern treatment approaches include nanoparticles (NPs) designed to target cancer cells, which release a therapeutic cargo facilitating the inhibition of their expansion,...

Microbial inulinases are enzymes produced by bacteria, yeasts, and fungi that can hydrolyze inulin into fructose and fructooligosaccharides (FOSs). The article discusses the various types of inulinases (exo- and endo-inulinases), microbial sources, b...

The spiroindoline framework is a privileged scaffold in medicinal chemistry, appearing in natural products and in synthetic bioactive compounds, such as BAY 1214784, RO8994, and RK-287107, with reported activities ranging from antimitotic effects to...

The genus Annona is scarcely investigated for its neuropharmacological and toxicological activities, especially regarding its seeds. To explore the effects on the central nervous system (CNS) and the acute toxicity (LD₅₀) of the polar extracts and fr...

Processing herbal medicine generates substantial quantities of by-products that are discarded as waste. These residues may retain polysaccharides, flavonoids, saponins, terpenoids, and other constituents with pharmacological relevance. This review di...

Finding cost-effective and eco-friendly ways to remove toxic heavy metals from wastewater remains a critical challenge for industrial sustainability. This study presents a comparative performance matrix of coal fly ash (CFA) and bone charcoal (BC) fo...

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with evolving pathogenesis. Biological barriers, especially intestinal and blood–brain barriers (BBBs) with their tight junctions (TJ), are gaining attention in recent years as...

A previous study identified [¹¹C]M503-1619 as a lead compound for positron emission tomography (PET) radiotracer development. The goal of the current study was to conduct a structure–activity relationship (SAR) study on M503-1619 to improve its...

Accurate shelf-life prediction of perishable products remains challenging because quality deterioration involves multiple physicochemical changes that are not adequately captured by conventional univariate approaches. This study proposes a multivaria...

The extraction of bioactive compounds using supercritical fluids has attracted increasing scientific attention as a sustainable alternative to conventional extraction methods. This study presents a bibliometric analysis aimed at providing an overview...

Aberrant self-assembly of ataxin-3 (ATX3) into amyloid aggregates is a key pathological event in spinocerebellar ataxia type 3 (SCA3). Bioactive nutraceutical compounds, particularly polyphenols, have emerged as promising candidates for targeting pro...

The first access to N-2, N-4-disubstituted pyrrolo[2,3-d][1,2,3]triazoles is reported herein. The series was generated using an orthogonal protecting group strategy from N-1, N-4-disubtituted pyrrolo[2,3-d][1,2,3]triazoles. N-Arylation by Ullman&ndas...

The accelerating transition toward low-carbon and resource-efficient energy systems is redefining the performance requirements imposed on functional materials [...]

Over the past three decades, pentaphosphaferrocene [Cp*Fe(η⁵-P₅)] (1*) has emerged as a versatile building block in coordination chemistry, enabling the construction of a wide range of nanosized spherical aggregates and extended coordination poly...

Cylindrical LiFePO₄ batteries are increasingly used in 3C consumer electronics, including computers, communication devices, and consumer electronic products, owing to their favorable safety characteristics, structural robustness, and stable electroch...

The structure–activity relationship of three oxyphosphonate inhibitors differing in heteroatom type (C, N, S) was examined to clarify their influence on the pitting corrosion resistance of ferritic–martensitic steel EP-450 in chloride med...