Nitrogen-Containing Heterocyclic Compounds in Drug Design: Synthesis, Characterization, and Biological Activity
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 41
Special Issue Editors
Interests: medicinal chemistry; heterocyclic compounds; design and synthesis; anticancer activity; antimicrobial activity; structure–activity relationship
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; nitrogen-containing heterocyclic compounds; Cu(II) complexes; design and synthesis; anticancer activity; structure-activity relationship
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nitrogen-containing heterocyclic compounds occupy a central position in modern medicinal chemistry due to their structural versatility, wide-ranging reactivity, and crucial roles in biological processes. They form the basis of nucleic acids, with purine and pyrimidine rings appearing in essential nitrogenous bases—adenine, guanine, cytosine, thymine, and uracil. Nitrogen heterocycles are also present in many other naturally occurring biomolecules such as vitamins, coenzymes, hormones, several amino acid derivatives, antibiotics, and alkaloids. Moreover, they are key components in a wide variety of drugs. Many antimicrobial agents, antidepressants, antihypertensive, and anticancer drugs contain heterocyclic nitrogen rings. Additionally, nitrogen-containing heterocyclic compounds are used in anti-diabetic, anticonvulsant, anti-inflammatory, and anti-migraine drugs, among many other applications. These structures often improve a drug’s ability to interact with biological targets such as enzymes, receptors, or nucleic acids, increasing their therapeutic efficacy and selectivity. Furthermore, medicinal chemists utilize nitrogen-based heterocycles to optimize pharmacokinetic properties such as solubility and metabolic stability. Their applications in chemistry, pharmacy, and medicine make them indispensable to scientific and technological advancement.
This Special Issue aims to present recent advances in the synthesis, characterization, and biological properties of nitrogen-containing heterocyclic compounds. We welcome submissions of both original research and review articles. Computational studies supporting the development of drug candidates are also encouraged.
Dr. Anita Kornicka
Dr. Łukasz Balewski
Guest Editors
Manuscript Submission Information
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Keywords
- nitrogen heterocycles
- synthesis
- structure
- biological activity
- drug development
- drug candidates
- in silico research
- computer-aided drug design
- medicinal chemistry
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