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Recent Advances in Analytical Methods for Drug Analysis

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 454

Special Issue Editor


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Guest Editor
Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
Interests: medicinal chemistry; drug analysis; drug stability; drug photostability; drug phototoxicity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Analytical procedures play a crucial role at every stage of a drug’s life cycle, from early development and research to the quality control of each batch released to the market. Modern technologies offer increasingly powerful tools, advanced chemometric support, and innovative data-processing techniques that enable faster and more effective assessment of drug quality. At the same time, however, the field faces significant challenges, including the rising costs of analytical experiments and growing environmental concerns.

I warmly invite you to contribute papers presenting new analytical procedures dedicated to pharmaceutical analysis. Submissions may cover spectroscopic, chromatographic, thermo- and electroanalytical approaches, as well as biological methods supported by multivariate statistics, chemometrics, and AI-based tools. We welcome studies focusing on bioactive compounds, biological drugs, and new pharmaceutical formulations, including investigations of active substances, their organic or elemental impurities, and enantiomers as well as metabolites.

Topics may also address Process Analytical Technology (PAT), the miniaturization method, and greener analytical strategies. This Special Issue aims to provide a comprehensive overview of state-of-the-art analytical tools and strategies employed in drug discovery, development, quality control and biomedical studies.

Prof. Dr. Anna Gumieniczek
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advances in analytical techniques
  • PAT and miniaturization
  • green chemistry
  • chemometrics and AI-based tools
  • new bioactive compounds, organic and biological drugs
  • organic and elemental impurities
  • enantiomers
  • metabolites and biomedical analysis

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Published Papers (1 paper)

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Research

21 pages, 2809 KB  
Article
Detecting the Physicochemical Transformations in Solid Drug Products Stored for Long Periods of Time—Insights into DSC Application
by Edyta Leyk, Tomasz Konarski and Marek Wesolowski
Molecules 2026, 31(8), 1280; https://doi.org/10.3390/molecules31081280 - 14 Apr 2026
Viewed by 259
Abstract
Since differential scanning calorimetry (DSC) is an excellent method for studying phase transformations in the solid state, the purpose of this study was to assess the suitability of DSC as a method for detecting physicochemical transformations occurring in solid drug products during storage, [...] Read more.
Since differential scanning calorimetry (DSC) is an excellent method for studying phase transformations in the solid state, the purpose of this study was to assess the suitability of DSC as a method for detecting physicochemical transformations occurring in solid drug products during storage, extending also beyond their expiration date. Based on the DSC measurements of 34 commercial drug products, they were divided into three groups characterized by the fact that the DSC curves show: (I) as dominant endothermic peaks reflecting active pharmaceutical ingredients (APIs) melting, with no additional peaks from excipients, (II) in addition to the peaks reflecting APIs melting, additional peaks related to the excipients, and (III) two peaks characteristic of lactose monohydrate dehydration and melting. Analysis of the temperature ranges and the shape of the DSC peaks showed no significant differences between the six series of measurements performed between 2011 and 2022, suggesting that physicochemical changes in drug products could not be detected during storage. Only the use of principal component analysis (PCA) made it possible to separate the DSC curves obtained during long-term storage of drug products. This allows DSC to be used to detect the first signs of deterioration, but only for drug formulations in group one. Of the drug products in groups two and three, this is only possible for 14 products. It follows that the suitability of DSC for identifying physicochemical changes in products stored for long periods of time is affected by the API content and complex composition of the tablet matrix. Full article
(This article belongs to the Special Issue Recent Advances in Analytical Methods for Drug Analysis)
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