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Molecules, Volume 29, Issue 6

March-2 2024 - 227 articles

Cover Story: Egg yolk proteins are better substrates for pepsin, trypsin and proteinase K compared to those from egg white. On the other hand, pepsin and proteinase K are more efficient, compared to trypsin, in breaking the intramolecular peptide bonds of the high-molecular-weight egg proteins. The enzyme-assisted hydrolysis allows for a significant increase in antioxidant activity, suggesting that many bioactive peptides are encrypted in an inactive form in the parent egg proteins. The hydrolysates obtained with proteinase K exhibit the highest antioxidant activity and the lowest residual IgE-binding capacity. The bioinformatics tools revealed that proteinase K is able to break the integrity of the main linear IgE-binding epitopes from ovalbumin and ovomucoid. Proteinase K is a promising tool for modulating the intrinsic properties of egg proteins. View this paper
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Articles (227)

  • Article
  • Open Access
12 Citations
7,172 Views
17 Pages

An In Vitro Examination of Whether Kratom Extracts Enhance the Cytotoxicity of Low-Dose Doxorubicin against A549 Human Lung Cancer Cells

  • Asep Bayu,
  • Siti Irma Rahmawati,
  • Firmansyah Karim,
  • Jonathan Ardhianto Panggabean,
  • Dasilva Primarindu Nuswantari,
  • Dwi Wahyu Indriani,
  • Peni Ahmadi,
  • Rendi Witular,
  • Ni Luh Putu Indi Dharmayanti and
  • Masteria Yunovilsa Putra

21 March 2024

Doxorubicin is an effective chemotherapeutic agent in the treatment of solid hematological and non-hematological carcinoma. However, its long-term usage could result in side effects, such as cardiomyopathy, chronic heart failure, neurotoxicity and ca...

  • Article
  • Open Access
22 Citations
4,010 Views
16 Pages

21 March 2024

Yak whey protein concentrates (YWPCs) have good functional properties, but there is still a gap in the study of their peptides. In this study, peptides were obtained by enzymatic hydrolysis, and the bioactivity of each ultrafiltration fraction was ev...

  • Article
  • Open Access
5 Citations
2,973 Views
10 Pages

21 March 2024

An enhanced, sustainable, and efficient method for synthesizing tacrine, achieving a 98% yield, has been developed by replacing volatile organic compounds with more eco-friendly solvents such as deep eutectic solvent (DESs). The optimized protocol sc...

  • Article
  • Open Access
12 Citations
2,387 Views
15 Pages

21 March 2024

Mn4+-doped red-light-emitting phosphors have become a research hotspot that can effectively enhance photosynthesis and promote morphogenesis in plants. Herein, the red phosphor La3Mg2NbO9:Mn4+ was synthesized through the solid-state reaction method....

  • Article
  • Open Access
7 Citations
3,632 Views
13 Pages

21 March 2024

Emerging evidence has demonstrated a strong correlation between vitamin D status and fatty liver disease. Aberrant hepatic fat infiltration contributes to oxidant overproduction, promoting metabolic dysfunction, and inflammatory responses. Vitamin D...

  • Article
  • Open Access
3 Citations
2,604 Views
16 Pages

Effect of Deashing Treatment on Ash Fusion Characteristics of Biochar from Bamboo Shoot Shells

  • Hao Ren,
  • Qi Gao,
  • Liangmeng Ni,
  • Mengfu Su,
  • Shaowen Rong,
  • Shushu Liu,
  • Yanhang Zhong and
  • Zhijia Liu

21 March 2024

To investigate the influence of deashing on fusion characteristics, a combined method of water and acid washing with different sequences (water washing followed by acid washing, and acid washing followed by water washing) was used to treat the biocha...

  • Article
  • Open Access
6 Citations
2,591 Views
19 Pages

Hybrid Peptide-Alkoxyamine Drugs: A Strategy for the Development of a New Family of Antiplasmodial Drugs

  • Ange W. Embo-Ibouanga,
  • Michel Nguyen,
  • Lucie Paloque,
  • Mathilde Coustets,
  • Jean-Patrick Joly,
  • Jean-Michel Augereau,
  • Nicolas Vanthuyne,
  • Raphaël Bikanga,
  • Naomie Coquin and
  • Anne Robert
  • + 5 authors

21 March 2024

The emergence and spread of drug-resistant Plasmodium falciparum parasites shed a serious concern on the worldwide control of malaria, the most important tropical disease in terms of mortality and morbidity. This situation has led us to consider the...

  • Article
  • Open Access
1 Citations
2,809 Views
12 Pages

Characterisation of Modular Polyketide Synthases Designed to Make Pentaene Analogues of Amphotericin B

  • Yuhao Song,
  • Mark Hogan,
  • Jimmy Muldoon,
  • Paul Evans and
  • Patrick Caffrey

21 March 2024

Glycosylated polyene macrolides are important antifungal agents that are produced by many actinomycete species. Development of new polyenes may deliver improved antibiotics. Here, Streptomyces nodosus was genetically re-programmed to synthesise penta...

  • Article
  • Open Access
1 Citations
2,930 Views
9 Pages

A Chiral-LC-MS Method for the Simultaneous Quantification of Short-Chain Fatty Acids and D/L-Lactate in the Ruminal Fluid of Dairy Cows

  • Zhiqian Liu,
  • S. Richard O. Williams,
  • Joe L. Jacobs,
  • Aodan S. O. Neachtain and
  • Simone Rochfort

21 March 2024

Short-chain fatty acids (SCFA) and lactate in ruminal fluid are products resulting from the microbial fermentation of substrates and can be used to reflect the composition and activity of the ruminal microbiome. Determination of SCFA and D-/L-lactate...

  • Article
  • Open Access
6 Citations
3,023 Views
11 Pages

Anticancer Potential and Safety Profile of β-Lapachone In Vitro

  • Karina Motta Melo Lima,
  • Luana França Calandrini de Azevedo,
  • Jorge Dores Rissino,
  • Valdicley Vieira Vale,
  • Erica Vanessa Souza Costa,
  • Maria Fani Dolabela,
  • Cleusa Yoshiko Nagamachi and
  • Julio Cesar Pieczarka

21 March 2024

Ipê is a plant of the Bignoniaceae family. Among the compounds extracted from this tree, lapachol is notable because its structural modification allows the production of β-lapachone, which has anticancer properties. The objective of this w...

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Molecules - ISSN 1420-3049