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Molecules, Volume 24, Issue 13

July-1 2019 - 171 articles

Cover Story: Nature has tailored a wide range of metalloenzymes that catalyze some of the most important biological processes in nature. Some of these metalloenzymes are involved in the production of highly reactive and unstable species, such as hydroxide anions, hydrides, radical species, and superoxide molecules. The formation of such reaction intermediates rarely occurs under biological conditions and only a rationalized selection of a particular metal ion, coordinated to a very specific group of ligands, and immersed in specific proteins allows such a reaction to proceed. This work analyzes a selection of hand-picked examples of different metalloenzymes illustrating this diversity, discussing the effect of different metal ions in similar reactions. View this paper.
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Articles (171)

  • Article
  • Open Access
44 Citations
14,883 Views
12 Pages

Ketogenic Diet-Induced Weight Loss is Associated with an Increase in Vitamin D Levels in Obese Adults

  • Maria Perticone,
  • Raffaele Maio,
  • Angela Sciacqua,
  • Edoardo Suraci,
  • Angelina Pinto,
  • Roberta Pujia,
  • Roberta Zito,
  • Simona Gigliotti,
  • Giorgio Sesti and
  • Francesco Perticone

Vitamin D is an important micronutrient involved in several processes. Evidence has shown a strong association between hypovitaminosis D and cardio-metabolic diseases, including obesity. A ketogenic diet has proven to be very effective for weight los...

  • Article
  • Open Access
25 Citations
6,215 Views
15 Pages

Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa

  • Alessio Malacrida,
  • Valeria Cavalloro,
  • Emanuela Martino,
  • Arianna Cassetti,
  • Gabriella Nicolini,
  • Roberta Rigolio,
  • Guido Cavaletti,
  • Barbara Mannucci,
  • Francesca Vasile and
  • Marcello Di Giacomo
  • + 2 authors

Multiple myeloma (MM) belongs to hematological cancers and its incidence is increasing worldwide. Despite recent advances in its therapy, MM still causes many deaths every year. In fact, current therapies sometimes fail and are associated with severe...

  • Article
  • Open Access
15 Citations
5,890 Views
12 Pages

Sample preparation is an important step in the isolation of target compounds from complex matrices to perform their reliable and accurate analysis. Hair samples are commonly pulverized or processed as fine cut, depending on preference, before extract...

  • Article
  • Open Access
20 Citations
3,925 Views
12 Pages

An Established HPLC-MS/MS Method for Evaluation of the Influence of Salt Processing on Pharmacokinetics of Six Compounds in Cuscutae Semen

  • Jiao Liu,
  • Shuhan Zou,
  • Wei Liu,
  • Jin Li,
  • Hui Wang,
  • Jiao Hao,
  • Jun He,
  • Xiumei Gao,
  • Erwei Liu and
  • Yanxu Chang

A sensitive and effective method was developed for clarifying the pharmacokinetic properties of six compounds (including hyperin, chlorogenic acid, neochlorogenic acid, p-coumaric acid, astragalin, and isoquercitrin) in two processed Cuscutae Semen s...

  • Article
  • Open Access
131 Citations
6,772 Views
24 Pages

In the present work, promising proton conducting solid polymer blend electrolytes (SPBEs) composed of chitosan (CS) and methylcellulose (MC) were prepared for electrochemical double-layer capacitor (EDLC) application with a high specific capacitance...

  • Article
  • Open Access
3 Citations
3,203 Views
14 Pages

Marylosides A-G, Norcycloartane Glycosides from Leaves of Cymbidium Great Flower ‘Marylaurencin’

  • Tatsuro Yoneyama,
  • Kanako Iseki,
  • Masaaki Noji,
  • Hiroshi Imagawa,
  • Toshihiro Hashimoto,
  • Sachiko Kawano,
  • Masaki Baba,
  • Yoshiki Kashiwada,
  • Tadahiro Yahagi and
  • Keiichi Matsuzaki
  • + 1 author

Seven novel norcycloartane glycosides, maryloside A–G (1–7), were isolated from the leaves of Cymbidium Great Flower ‘Marylaurencin’, along with a known norcycloartane glycoside, cymbidoside (8). These structures were determin...

  • Article
  • Open Access
1 Citations
3,034 Views
14 Pages

Similar Safety Profile of the Enantiomeric N-Aminoalkyl Derivatives of Trans-2-Aminocyclohexan-1-ol Demonstrating Anticonvulsant Activity

  • Karolina Słoczyńska,
  • Paulina Koczurkiewicz,
  • Kamil Piska,
  • Beata Powroźnik,
  • Katarzyna Wójcik-Pszczoła,
  • Katarzyna Klaś,
  • Magdalena Wyszkowska-Kolatko and
  • Elżbieta Pękala

Epilepsy is one of the most common neurological disorder in the world. Many antiepileptic drugs cause multiple adverse effects. Moreover, multidrug resistance is a serious problem in epilepsy treatment. In the present study we evaluated the safety pr...

  • Article
  • Open Access
18 Citations
3,583 Views
13 Pages

Variety Identification of Orchids Using Fourier Transform Infrared Spectroscopy Combined with Stacked Sparse Auto-Encoder

  • Yunfeng Chen,
  • Yue Chen,
  • Xuping Feng,
  • Xufeng Yang,
  • Jinnuo Zhang,
  • Zhengjun Qiu and
  • Yong He

The feasibility of using the fourier transform infrared (FTIR) spectroscopic technique with a stacked sparse auto-encoder (SSAE) to identify orchid varieties was studied. Spectral data of 13 orchids varieties covering the spectral range of 4000&ndash...

  • Article
  • Open Access
24 Citations
3,947 Views
17 Pages

Ionic Liquid-Microwave-Based Extraction of Biflavonoids from Selaginella sinensis

  • Dan Li,
  • Chengxin Sun,
  • Jiaqiang Yang,
  • Xiankui Ma,
  • Yongmei Jiang,
  • Shaoliang Qiu and
  • Gang Wang

Selaginella sinensis (Desv.) Spring has been used for many years as traditional Chinese medicine (TCM) for many years. Recently, ionic liquids (ILs) have attracted great attentions in extraction and separation technology of TCM as a new green solvent...

  • Article
  • Open Access
6 Citations
5,346 Views
19 Pages

Transcription factors are proteins lying at the endpoint of signaling pathways that control the complex process of DNA transcription. Typically, they are structurally disordered in the inactive state, but in response to an external stimulus, like a s...

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Molecules - ISSN 1420-3049