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Preclinical Evaluation of Radiolabeled Peptides for PET Imaging of Glioblastoma Multiforme

Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, 77900 Olomouc, Czech Republic
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Academic Editors: Mohamed Abdel-Rehim, Christer Halldin and Mohammad Mahdi Moein
Molecules 2019, 24(13), 2496; https://doi.org/10.3390/molecules24132496
Received: 7 June 2019 / Revised: 2 July 2019 / Accepted: 7 July 2019 / Published: 8 July 2019
(This article belongs to the Special Issue Analytical Chemistry in Clinical Studies and PET Developments)
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Abstract

In this study, we have compared four 68Ga-labeled peptides (three Arg-Gly-Asp (RGD) peptides and substance-P) with two 18F-tracers clinically approved for tumor imaging. We have studied in vitro and in vivo characteristics of selected radiolabeled tracers in a glioblastoma multiforme tumor model. The in vitro part of the study was mainly focused on the evaluation of radiotracers stability under various conditions. We have also determined in vivo stability of studied 68Ga-radiotracers by analysis of murine urine collected at various time points after injection. The in vivo behavior of tested 68Ga-peptides was evaluated through ex vivo biodistribution studies and PET/CT imaging. The obtained data were compared with clinically used 18F-tracers. 68Ga-RGD peptides showed better imaging properties compared to 18F-tracers, i.e., higher tumor/background ratios and no accumulation in non-target organs except for excretory organs. View Full-Text
Keywords: PET; RGD peptides; biodistribution; gallium-68; 18F-FDG; 18F-FLT; glioblastoma multiforme PET; RGD peptides; biodistribution; gallium-68; 18F-FDG; 18F-FLT; glioblastoma multiforme
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Novy, Z.; Stepankova, J.; Hola, M.; Flasarova, D.; Popper, M.; Petrik, M. Preclinical Evaluation of Radiolabeled Peptides for PET Imaging of Glioblastoma Multiforme. Molecules 2019, 24, 2496.

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