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Special Issue "Cardiovascular Nanomedicines and Nanomaterials "

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 6 May 2019

Special Issue Editors

Guest Editor
Dr. Iwona Cicha

Cardiovascular Nanomedicine Unit, Section of Experimental Oncology and Nanomedicine (SEON), ENT-Department, University Hospital Erlangen, Erlangen, Germany
Website | E-Mail
Interests: nanomedicine; magnetic nanoparticles; drug delivery; biomaterials; biofabrication; vascular biology; hemorheology
Guest Editor
Dr. László Dézsi

Department of Pathophysiology, Nanomedicine Research and Education Center, Semmelweis University, Budapest, Hungary
Website | E-Mail
Interests: cardiovascular physiology; hypersensitivity reactions (HSRs) to nanomedicines; in vivo models of HSRs; complement activation related pseudoallergy (CARPA); liposomes; SPIONs
Guest Editor
Dr. May Azzawi

Healthcare Science Research Institute, Faculty of Science and Engineering, Manchester Metropolitan University, Mamchester, UK
Website | E-Mail
Phone: 0161 247 3332
Interests: vascular contractility and function; nanotechnology and regenerative medicine; nanomedicine and nanotoxicology; immunopathogenesis of heart and lung diseases

Special Issue Information

Dear colleagues,

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the world, with an increasing prevalence due to the aging of populations. Nanomedicine offers unique opportunities and novel approaches for the diagnosis and treatment of CVD. It is estimated that this scientific field will have an enormous impact, especially on molecular imaging, targeted drug delivery techniques, and tissue engineering. The continuing efforts and advances in medical nanotechnology are expected to provide us with more personalized tools to improve risk assessment, the allocation of preventive therapy, and the monitoring of treatment efficacy for CVD.

This Special Issue aims to present an overview of this field, including recent developments in nanomedicine, in order to better understand the mechanisms of diseases and improve both the safety and the outcome of applying nanomedicinal products in CVD patients. Potential topics include, but not limited to:

  • Drug delivery to cardio-, cerebro-, retino-, and renovascular disorders;
  • Nano-agents for imaging myocardial infarction, atherosclerosis, aneurysms, and thrombosis;
  • Nanotechnologies for CVD lipidomics, proteomics, and metabolomics;
  • Nano-patterned and nanoparticle-eluting stents;
  • Regenerative nanomedicine for vascular prostheses;
  • Cardiovascular risks related to intravascular nanomedicines;
  • Immuno-toxicology and immunogenicity of exposure by nanoparticles;
  • Nanoparticle-target cell interaction modeling.

We invite investigators to contribute original research articles, as well as review articles that will stimulate the continuing efforts in this exciting and continuously expanding field.

Dr. Iwona Cicha
Dr. László Dézsi
Dr. May Azzawi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular drug delivery nanosystems;
  • thrombolytic nanoparticles;
  • nanoparticles for cardiac imaging;
  • nano-agents for the detection of atherosclerosis and thrombosis;
  • nanomaterials and nanofibers for cardiovascular regeneration;
  • nano-patterned vascular devices;
  • hypersensitvity reactions to nanomedicines and risk mitigation

Published Papers (1 paper)

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Research

Open AccessArticle Bimodal Fucoidan-Coated Zinc Oxide/Iron Oxide-Based Nanoparticles for the Imaging of Atherothrombosis
Molecules 2019, 24(5), 962; https://doi.org/10.3390/molecules24050962
Received: 2 February 2019 / Revised: 3 March 2019 / Accepted: 6 March 2019 / Published: 8 March 2019
PDF Full-text (3507 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
A polyol method was used to obtain ultrasmall ZnO nanoparticles (NPs) doped with iron ions and coated with a low molecular weight fucoidan in order to perform in vivo MR and ex vivo fluorescence imaging of athrothrombosis. During the synthesis, the early elimination [...] Read more.
A polyol method was used to obtain ultrasmall ZnO nanoparticles (NPs) doped with iron ions and coated with a low molecular weight fucoidan in order to perform in vivo MR and ex vivo fluorescence imaging of athrothrombosis. During the synthesis, the early elimination of water by azeotropic distillation with toluene allowed us to produce NPs which size, determined by XRD and TEM, decreased from 7 nm to 4 nm with the increase of iron/zinc ratios from 0.05 to 0.50 respectively. For the highest iron content (NP-0.50) NPs were evidenced as a mixture of nanocrystals made of wurtzite and cubic phase with a molar ratio of 2.57:1, although it was not possible to distinguish one from the other by TEM. NP-0.50 were superparamagnetic and exhibited a large emission spectrum at 470 nm when excited at 370 nm. After surface functionalization of NP-0.50 with fucoidan (fuco-0.50), the hydrodynamic size in the physiological medium was 162.0 ± 0.4 nm, with a corresponding negative zeta potential of −48.7 ± 0.4 mV, respectively. The coating was evidenced by FT-IR spectra and thermogravimetric analysis. Aqueous suspensions of fuco-0.50 revealed high transverse proton relaxivities (T2) with an r2 value of 173.5 mM−1 s−1 (300 K, 7.0 T) and remained stable for more than 3 months in water or in phosphate buffer saline without evolution of the hydrodynamic size and size distribution. No cytotoxic effect was observed on human endothelial cells up to 48 h with these NPs at a dose of 0.1 mg/mL. After injection into a rat model of atherothrombosis, MR imaging allowed the localization of diseased areas and the subsequent fluorescence imaging of thrombus on tissue slices. Full article
(This article belongs to the Special Issue Cardiovascular Nanomedicines and Nanomaterials )
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