Anti-Cancer Drug: Discovery, Development and Combination

Dear Colleagues,

Cancer is recognized as a multifactorial disease and its progression is regulated by extremely complex mechanisms. Indeed, numerous factors, such as DNA methylation, miRNA, growth factors, angiogenesis, and the immune system, are closely associated with carcinogenesis, invasion, metastasis, and prognosis. In addition, a variety of molecules, cancer stem cells, and long non-coding RNAs play important roles in the resistance to cancer therapies. Furthermore, the contribution of such carcinogenic factors to malignant behavior is dependent on the type of cancer and the stage of the disease.

Armed with this knowledge, researchers have discovered many promising candidates for cancer therapy, and some are now being tested in clinical trials. Various new therapeutic targets, including chemical compounds and natural products, have been identified from basic and translational studies.

The aim of this Special Issue is to collect research papers, reviews, and communications focused on the discovery and development of anti-cancer drugs, as well as potential therapeutic targets, for various types of cancers. Moreover, clinical and translational studies on anti-cancer drugs used to improve the efficacy of conservative therapies, to decrease the number of residual cancer cells after operation, and to maintain the quality of life in patients with cancer, are invited.

Assoc. Prof. Yasuyoshi Miyata
Guest Editor

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