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Open AccessArticle

Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities

Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 7008530, Japan
Department of Biochemistry, College of Medicine, Qassim University, Al-Qassim 51452, Saudi Arabia
Department of Molecular Biology, Genetic Engineering & Biotechnology Institute, University of Sadat City, Sadat City 32958, Egypt
Biochemistry Division, Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koom 32512, Egypt
Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koom 32512, Egypt
Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, SE-751 23 Uppsala, Sweden
Department of Bee Research, Plant Protection Research Institute, Agricultural Research Centre, Giza 12627, Egypt
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang, Malaysia
Pharmacognosy Group, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Al-Rayan Research and Innovation Center, Al-Rayan Colleges, Medina 42541, Saudi Arabia
Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China
Clinical Research Centre, Karolinska University Hospital, 14186 Huddinge, Sweden
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden
College of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Authors to whom correspondence should be addressed.
Molecules 2019, 24(13), 2495;
Received: 2 June 2019 / Revised: 30 June 2019 / Accepted: 5 July 2019 / Published: 8 July 2019
(This article belongs to the Special Issue Phytochemicals in Medicine and Food)
Background/Aim: Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers. Methods: The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model. Results: A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, 1H-NMR and 13C-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 µg/mL, respectively. Conclusion: Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet. View Full-Text
Keywords: Alpinia zerumbet; 5,6-dehydrokawain; Ehrlich ascites carcinoma; anti-tumor; anti-oxidant Alpinia zerumbet; 5,6-dehydrokawain; Ehrlich ascites carcinoma; anti-tumor; anti-oxidant
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Zahra, M.H.; Salem, T.A.; El-Aarag, B.; Yosri, N.; EL-Ghlban, S.; Zaki, K.; Marei, A.H.; Abd El-Wahed, A.; Saeed, A.; Khatib, A.; AlAjmi, M.F.; Shathili, A.M.; Xiao, J.; Khalifa, S.A.M.; El-Seedi, H.R. Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities. Molecules 2019, 24, 2495.

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