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Special Issue "Phytochemicals in Medicine and Food"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 August 2020.

Special Issue Editors

Prof. Dr. Jianbo Xiao
grade E-Mail Website
Guest Editor
Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
Interests: phytochemicals; polyphenols; diabetes; function food; natural products; glycosylation; biological activity; flavonoids; stilbenoids; pharmacokinetics; nutrition and metabolism; polyphenol-protein interaction
Special Issues and Collections in MDPI journals
Prof. Dr. Yanbo Zhang
E-Mail Website
Guest Editor
School of Chinese Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China
Tel. 852-2589 0481
Interests: Chinese medicine; Alzheimer's disease; lung cancer; diabetic nephropathy; molecular mechanisms; phytochemicals and analysis; molecular identification; formulation pharmacology; natural products
Prof. Dr. Hui Ni
E-Mail Website
Guest Editor
College of Food and Biology Engineering, Jimei University, Xiamen, China
Interests: phytochemicals; polyphenols; flavonoids; glycosylation; biological activity; polyphenol-protein interaction

Special Issue Information

Dear Colleagues,

This Special Issue is related to the 4th International Symposium on Phytochemicals in Medicine and Food (4-ISPMF), which will be held at Xi’an, 25–30 June, 2020. This Special Issue seeks updated and new knowledge on the phytochemicals in medicine and food. Evidence from epidemiological investigations shows that natural phytochemicals have received increased attention due to their considerable benefits in the prevention and management of modern diseases, such as cancers, diabetes, and cardiovascular diseases. This Special Issue will shape the future research directions regarding this important phytomedicine source. Our purpose is to feature high-quality, advanced research and knowledge, contributed by various research groups working on phytochemicals. We invite researchers including non‒participants of 4-ISPMF to contribute reviews and reports of their recent work on the chemistry, biology, and biotechnology of phytochemicals.

The Special Issue will focus on phytochemicals in medicine and food, including following aspects:

  1. Natural products for preventing and managing modern diseases.
  2. Mechanisms of phytochemicals for the therapy and chemoprevention of modern diseases.
  3. Importance of natural phytochemicals in medicine and food
  4. Structure–activity relationship and modeling for natural drug design
  5. Natural antioxidants and human health
  6. New strategies for using natural products to manage diseases
  7. Pharmacokinetics and biotransformation of phytochemicals
  8. Nutrition and metabolism of phytochemicals

Prof. Dr. Jianbo Xiao
Prof. Dr. Yanbo Zhang
Prof. Dr. Hui Ni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Phytochemicals
  • Medicinal plants
  • Natural products
  • Phytomedicine
  • Metabolism
  • Prevention
  • Chemoprevention
  • Function food
  • Structure–activity relationship
  • Biotransformation

Published Papers (5 papers)

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Research

Open AccessArticle
Phytochemical Study of Stem and Leaf of Clausena lansium
Molecules 2019, 24(17), 3124; https://doi.org/10.3390/molecules24173124 - 28 Aug 2019
Abstract
Clausena lansium Lour. Skeels (Rutaceae) is widely distributed in South China and has historically been used as a traditional medicine in local healthcare systems. Although the characteristic components (carbazole alkaloids and coumarins) of C. lansium have been found to possess a wide variety [...] Read more.
Clausena lansium Lour. Skeels (Rutaceae) is widely distributed in South China and has historically been used as a traditional medicine in local healthcare systems. Although the characteristic components (carbazole alkaloids and coumarins) of C. lansium have been found to possess a wide variety of biological activities, little attention has been paid toward the other components of this plant. In the current study, phytochemical analysis of isolates from a water-soluble stem and leaf extract of C. lansium led to the identification of 12 compounds, including five aromatic glycosides, four sesquiterpene glycosides, two dihydrofuranocoumarin glycosides, and one adenosine. All compounds were isolated for the first time from the genus Clausena, including a new aromatic glycoside (1), a new dihydrofuranocoumarin glycoside (6), and two new sesquiterpene glycosides (8 and 9). The phytochemical structures of the isolates were elucidated using spectroscopic analyses including NMR and MS. The existence of these compounds demonstrates the taxonomic significance of C. lansium in the genus Clausena and suggests that some glycosides from this plant probably play a role in the anticancer activity of C. lansium to some extent. Full article
(This article belongs to the Special Issue Phytochemicals in Medicine and Food)
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Open AccessArticle
The Effect of Tartary Buckwheat Flavonoids in Inhibiting the Proliferation of MGC80-3 Cells during Seed Germination
Molecules 2019, 24(17), 3092; https://doi.org/10.3390/molecules24173092 - 26 Aug 2019
Abstract
Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn) is rich in functional compounds such as rutin, quercetin, d-chiro-inositol, dietary fiber, and essential amino acids. Electric field (EF) treatment before sprout germination results in physiological and chemical changes, and some alterations might lead to [...] Read more.
Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn) is rich in functional compounds such as rutin, quercetin, d-chiro-inositol, dietary fiber, and essential amino acids. Electric field (EF) treatment before sprout germination results in physiological and chemical changes, and some alterations might lead to positive applications in plant seeds. MTT assay showed that the effect of total flavonoids on human gastric cancer cell line MGC80-3 was significantly changed after EF treatment for different germination days (3–7 days). Among them, the total flavonoids of tartary buckwheat (BWTF) on the third day had the most obvious inhibitory effect on MGC80-3 (p < 0.01). In addition, flow cytometry evidenced that different ratios of quercetin and rutin had effects on the proliferation of MGC80-3. The same content of quercetin and rutin had the best effect, reaching 6.18 ± 0.82%. The anti-cancer mechanism was mainly promoted by promoting the expression of apoptotic proteins. The expression of Bax/Bcl-2 and caspase-8 in MGC80-3 cells was mediated by BWTFs. This study has good research value for improving the biological and economic value of tartary buckwheat. Full article
(This article belongs to the Special Issue Phytochemicals in Medicine and Food)
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Open AccessArticle
Involvement of Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and the PI3K/AKT/mTOR Pathway in Nobiletin-Induced Apoptosis of Human Bladder Cancer Cells
Molecules 2019, 24(16), 2881; https://doi.org/10.3390/molecules24162881 - 08 Aug 2019
Abstract
Nobiletin (NOB) is a polymethoxylated flavonoid isolated from citrus fruit peel that has been shown to possess anti-tumor, antithrombotic, antifungal, anti-inflammatory and anti-atherosclerotic activities. The main purpose of this study was to explore the potential of using NOB to induce apoptosis in human [...] Read more.
Nobiletin (NOB) is a polymethoxylated flavonoid isolated from citrus fruit peel that has been shown to possess anti-tumor, antithrombotic, antifungal, anti-inflammatory and anti-atherosclerotic activities. The main purpose of this study was to explore the potential of using NOB to induce apoptosis in human bladder cancer cells and study the underlying mechanism. Using an MTT assay, agarose gel electrophoresis, a wound-healing assay, flow cytometry, and western blot analysis, this study investigated the signaling pathways involved in NOB-induced apoptosis in BFTC human bladder cancer cells. Our results showed that NOB at concentrations of 60, 80, and 100 μM inhibited cell growth by 42%, 62%, and 80%, respectively. Cells treated with 60 μM NOB demonstrated increased DNA fragmentation, and flow cytometry analysis confirmed that the treatment caused late apoptotic cell death. Western blot analysis showed that mitochondrial dysfunction occurred in NOB-treated BFTC cells, leading to cytochrome C release into cytosol, activation of pro-apoptotic proteins (caspase-3, caspase-9, Bad, and Bax), and inhibition of anti-apoptotic proteins (Mcl-1, Bcl-xl, and Bcl-2). NOB-induced apoptosis was also mediated by regulating endoplasmic reticulum stress via the PERK/elF2α/ATF4/CHOP pathway, and downregulating the PI3K/AKT/mTOR pathway. Our results suggested that the cytotoxic and apoptotic effects of NOB on bladder cancer cells are associated with endoplasmic reticulum stress and mitochondrial dysfunction. Full article
(This article belongs to the Special Issue Phytochemicals in Medicine and Food)
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Open AccessArticle
Screening and Evaluation of Xanthine Oxidase Inhibitors from Gnetum parvifolium in China
Molecules 2019, 24(14), 2671; https://doi.org/10.3390/molecules24142671 - 23 Jul 2019
Abstract
As a traditional natural medicine for treating many kinds of diseases, Gnetum parvifolium showed apparent inhibition on xanthine oxidase (XO). In this study, ultrafiltration combined with liquid chromatography-mass spectrometry (LC-MS) is used for the screening of XO inhibitors from Gnetum parvifolium. Their [...] Read more.
As a traditional natural medicine for treating many kinds of diseases, Gnetum parvifolium showed apparent inhibition on xanthine oxidase (XO). In this study, ultrafiltration combined with liquid chromatography-mass spectrometry (LC-MS) is used for the screening of XO inhibitors from Gnetum parvifolium. Their antioxidation, XO inhibition, and enzymic kinetic parameters are also determined. Finally, piceatannol (1), rhaponiticin (2), resveratrol (3), and isorhapontigenin (4) are screened out and identified as XO inhibitors from the extract of Gnetum parvifolium. Four inhibitors show better inhibition than allopurinol and good radical scavenging abilities. However, the antioxidant activities are weaker than ascorbic acid. The kinetic parameters illustrate the inhibition mode of XO by piceatannol is competitive type, while the inhibition modes for rhaponiticin, resveratrol and isorhapontigenin are uncompetitive types. In order to evaluate the difference among samples obtained in China, the amounts of four inhibitors and related activities in 20 samples are assessed and analyzed by partial least squares analysis. The results indicate piceatannol contribute the highest coefficients in three kinds of activities. Based on these findings, more comprehensive research on pharmaceutical and biochemical activities of these four XO inhibitors could be conducted in future. Full article
(This article belongs to the Special Issue Phytochemicals in Medicine and Food)
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Open AccessArticle
Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities
Molecules 2019, 24(13), 2495; https://doi.org/10.3390/molecules24132495 - 08 Jul 2019
Cited by 1
Abstract
Background/Aim: Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers. Methods: The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well [...] Read more.
Background/Aim: Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers. Methods: The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model. Results: A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, 1H-NMR and 13C-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 µg/mL, respectively. Conclusion: Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet. Full article
(This article belongs to the Special Issue Phytochemicals in Medicine and Food)
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