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Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa

1
School of Medicine and Surgery, University of Milan-Bicocca, 20900 Monza, Italy
2
Experimental Neurology Unit, University of Milano-Bicocca, 20900 Monza, Italy
3
Department of Earth and Environmental Sciences, University of Pavia, 27100 Pavia, Italy
4
CREA, Research Centre for Vegetable and Ornamental Crops, 18038 Sanremo, Italy
5
Center of Large Equipment, University of Pavia, 27100 Pavia, Italy
6
Department of Chemistry, University of Milan, 20133 Milano, Italy
7
Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy
*
Authors to whom correspondence should be addressed.
Authors contributed equally to this work.
Academic Editor: Ericsson Coy-Barrera
Molecules 2019, 24(13), 2500; https://doi.org/10.3390/molecules24132500
Received: 9 May 2019 / Revised: 4 July 2019 / Accepted: 6 July 2019 / Published: 9 July 2019
(This article belongs to the Special Issue Recent Advances in Anticancer Drugs)
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Abstract

Multiple myeloma (MM) belongs to hematological cancers and its incidence is increasing worldwide. Despite recent advances in its therapy, MM still causes many deaths every year. In fact, current therapies sometimes fail and are associated with severe adverse effects, including neurotoxicity. As a part of our ongoing efforts to discover new potential therapies against MM, we prepared Hibiscus sabdariffa extracts obtained by a microwave-assisted solvent extraction and investigate their activity by in vitro assays on the RPMI-8226 cell line. The bioguided fractionation of the crude ethanolic extract allowed the identification of HsFC as the most effective extract. We assessed cell viability (MTT and Tripan blue test), cell migration (Boyden chamber assay), and neurotoxicity (DRG neurotoxicity assay). The promising results prompted us to further fractionate HsFC and we obtained two molecules effective against RPMI-8226 cells without neurotoxic effects at their active concentrations. Moreover, both compounds are able to significantly reduce cell migration. View Full-Text
Keywords: Multiple myeloma; Hibiscus sabdariffa; nature-aided drug discovery; bioguided assay fractionation; Hib-ester; Hib-carbaldehyde Multiple myeloma; Hibiscus sabdariffa; nature-aided drug discovery; bioguided assay fractionation; Hib-ester; Hib-carbaldehyde
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Malacrida, A.; Cavalloro, V.; Martino, E.; Cassetti, A.; Nicolini, G.; Rigolio, R.; Cavaletti, G.; Mannucci, B.; Vasile, F.; Giacomo, M.D.; Collina, S.; Miloso, M. Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa. Molecules 2019, 24, 2500.

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