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Ionic Liquid-Microwave-Based Extraction of Biflavonoids from Selaginella sinensis

School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563003, China
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Molecules 2019, 24(13), 2507; https://doi.org/10.3390/molecules24132507
Received: 12 June 2019 / Revised: 5 July 2019 / Accepted: 6 July 2019 / Published: 9 July 2019
(This article belongs to the Section Green Chemistry)
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Abstract

Selaginella sinensis (Desv.) Spring has been used for many years as traditional Chinese medicine (TCM) for many years. Recently, ionic liquids (ILs) have attracted great attentions in extraction and separation technology of TCM as a new green solvent. In this paper, microwave assisted extraction-IL (MAE-IL) that extracted amentoflavone (AME) and hinokiflavone (HIN) from Selaginella sinensis was reported for the first time. The contents of two biflavonoids were simultaneously determined by a high performance liquid chromatography (HPLC) method. After different ionic liquids were compared, it was found [C6mim]BF4 had a high selectivity and efficiency. Moreover, the important extraction conditions, including solid-liquid ratio, IL concentration, extraction time, microwave power and radiation temperature, were also investigated and optimized by response surface methodology (RSM) using AME and HIN yields as index. The results showed that the extraction yields of AME and HIN from S. sinensis were 1.96 mg/g and 0.79 mg/g, respectively, under the optimal process parameters (0.55 mmol/L, 300 W, 40 min, 1:11 g/mL and 48 °C). Compared with the conventional extraction methods, MAE-IL could not only achieve higher yield in shorter time, but also could reduce the consumption of solvent. This effective, rapid and green MAE-IL method was suitable for the extraction of AME and HIN. View Full-Text
Keywords: Selaginella sinensis; ionic liquids; amentoflavone; hinokiflavone; microwave extraction; HPLC; response surface methodology Selaginella sinensis; ionic liquids; amentoflavone; hinokiflavone; microwave extraction; HPLC; response surface methodology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Li, D.; Sun, C.; Yang, J.; Ma, X.; Jiang, Y.; Qiu, S.; Wang, G. Ionic Liquid-Microwave-Based Extraction of Biflavonoids from Selaginella sinensis. Molecules 2019, 24, 2507.

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