Next Article in Journal
The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues
Next Article in Special Issue
Magnetic Accumulation of SPIONs under Arterial Flow Conditions: Effect of Serum and Red Blood Cells
Previous Article in Journal
Sequence-Specific DNA Binding by Noncovalent Peptide–Azocyclodextrin Dimer Complex as a Suitable Model for Conformational Fuzziness
Previous Article in Special Issue
Phagocytosis of a PFOB-Nanoemulsion for 19F Magnetic Resonance Imaging: First Results in Monocytes of Patients with Stable Coronary Artery Disease and ST-Elevation Myocardial Infarction
Article Menu
Issue 13 (July-1) cover image

Export Article

Open AccessArticle

Hemodynamic Effects on Particle Targeting in the Arterial Bifurcation for Different Magnet Positions

1
Centre for Fundamental and Advanced Technical Research, Romanian Academy—Timisoara Branch, Mihai Viteazul Str. 24, RO-300223 Timisoara, Romania
2
Faculty of Physics, West University of Timisoara, Vasile Parvan Str. 1, RO-300222 Timisoara, Romania
3
University of Medicine and Pharmacy “Victor Babes” Timisoara, P-ta Eftimie Murgu 2, RO-300041 Timisoara, Romania
*
Author to whom correspondence should be addressed.
Academic Editors: Iwona Cicha, László Dézsi and May Azzawi
Molecules 2019, 24(13), 2509; https://doi.org/10.3390/molecules24132509
Received: 31 May 2019 / Revised: 5 July 2019 / Accepted: 8 July 2019 / Published: 9 July 2019
(This article belongs to the Special Issue Cardiovascular Nanomedicines and Nanomaterials )
  |  
PDF [8850 KB, uploaded 11 July 2019]
  |  

Abstract

The present study investigated the possibilities and feasibility of drug targeting for an arterial bifurcation lesion to influence the host healing response. A micrometer sized iron particle was used only to model the magnetic carrier in the experimental investigation (not intended for clinical use), to demonstrate the feasibility of the particle targeting at the lesion site and facilitate the new experimental investigations using coated superparamagnetic iron oxide nanoparticles. Magnetic fields were generated by a single permanent external magnet (ferrite magnet). Artery bifurcation exerts severe impacts on drug distribution, both in the main vessel and the branches, practically inducing an uneven drug concentration distribution in the bifurcation lesion area. There are permanently positioned magnets in the vicinity of the bifurcation near the diseased area. The generated magnetic field induced deviation of the injected ferromagnetic particles and were captured onto the vessel wall of the test section. To increase the particle accumulation in the targeted region and consequently avoid the polypharmacology (interaction of the injected drug particles with multiple target sites), it is critical to understand flow hemodynamics and the correlation between flow structure, magnetic field gradient, and spatial position. View Full-Text
Keywords: magnetic particle targeting; arterial bifurcation; particle accumulation; hemodynamics magnetic particle targeting; arterial bifurcation; particle accumulation; hemodynamics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Bernad, S.I.; Susan-Resiga, D.; Bernad, E.S. Hemodynamic Effects on Particle Targeting in the Arterial Bifurcation for Different Magnet Positions. Molecules 2019, 24, 2509.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top